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From:PLoS ONE (Vol. 8, Issue 1) Peer-ReviewedAuthor(s): Hao Zhang 1 , Dror Berel 2 , 4 , Yanping Wang 1 , Ping Li 1 , Neil A. Bhowmick 3 , Robert A. Figlin 3 , Hyung L. Kim 1 , 4 , * Introduction Renal cell carcinoma (RCC) is the most common malignancy of...
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From:Nature Clinical Practice Oncology (Vol. 5, Issue 10) Peer-ReviewedTemsirolimus is a specific inhibitor of mammalian target of rapamycin (mTOR) that is approved for the treatment of advanced renal cell carcinoma. mTOR is unique among antitumor drug targets because it is a convergence...
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From:Nature Reviews Urology (Vol. 11, Issue 5) Peer-ReviewedUse of clinically active agents, such as kinase inhibitors, before nephrectomy is safe and feasible and can decrease the size of primary tumours, enabling optimization of the surgical approach. However, the overall...
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From:Expert Review of Anticancer Therapy (Vol. 8, Issue 6) Peer-ReviewedAuthor(s): Karen L Reckamp [[dagger]] 1 , Robert M Strieter 2 , Robert A Figlin 3 Keywords: angiogenesis; chemokine; metastatic potential; renal cell carcinoma; treatment Increased understanding of the...