Showing Results for
- 1From:Molecular Cell (Vol. 82, Issue 13) Peer-ReviewedAbstract Only
- 2From:Mitochondrion (Vol. 11, Issue 4) Peer-ReviewedAbstract Only
- 3From:Science (Vol. 343, Issue 6166) Peer-ReviewedAbstract Only
- 4From:Cancer Cell (Vol. 30, Issue 2) Peer-ReviewedAbstract Only
- 5From:Science (Vol. 326, Issue 5950) Peer-ReviewedAbstract Only
- 6From:IEEE Transactions on Microwave Theory and Techniques (Vol. 53, Issue 11) Peer-ReviewedAbstract Only
- 7From:eLife (Vol. 6) Peer-ReviewedActivating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit...
- 8From:Genome Biology (Vol. 16, Issue 1) Peer-ReviewedCRISPR-based approaches have quickly become a favored method to perturb genes to uncover their functions. Here, we review the key considerations in the design of genome editing experiments, and survey the tools and...
- 9From:Genome Research (Vol. 23, Issue 4) Peer-ReviewedCitation Only
- 10From:Science (Vol. 351, Issue 6278) Peer-ReviewedAbstract Only
- 11From:Nature Biotechnology (Vol. 32, Issue 12) Peer-ReviewedComponents of the prokaryotic clustered, regularly interspaced, short palindromic repeats (CRISPR) loci have recently been repurposed for use in mammalian cells (1-6). The CRISPR-associated (Cas) (9) can be programmed...
- 12From:Proceedings of the National Academy of Sciences of the United States (Vol. 110, Issue 24) Peer-ReviewedAbstract Only
- 13From:Proceedings of the National Academy of Sciences of the United States (Vol. 111, Issue 4) Peer-ReviewedAbstract Only
- 14From:Genes & Development (Vol. 24, Issue 23) Peer-ReviewedCitation Only
- 15From:Journal of Clinical Investigation (Vol. 128, Issue 1) Peer-ReviewedPharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma, amplification of the oncogene MYCN is associated with...
- 16From:Journal of Clinical Investigation (Vol. 120, Issue 11) Peer-ReviewedKRAS is one of the most frequently mutated human oncogenes. In some settings, oncogenic KRAS can trigger cellular senescence, whereas in others it produces hyperproliferation. Elucidating the mechanisms regulating these...
- 17From:Cell Systems (Vol. 5, Issue 5) Peer-ReviewedAbstract Only
- 18From:eLife (Vol. 9) Peer-ReviewedThe ability of the immune system to avoid autoimmune disease relies on tolerization of thymocytes to self-antigens whose expression and presentation by thymic medullary epithelial cells (mTECs) is controlled...
- 19From:eLife (Vol. 6) Peer-ReviewedGenomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes...
Choose how you want to be alerted when new results for your search become available.
Subscribe to Gale's RSS feed to get content delivered to your favorite RSS aggregator. Copy and paste the URL below into your reader:
Tell us where to send the alert and how often you want to receive it