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• Select NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.

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  NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.

  Authors:Yiannis Drosos, Jacquelyn A. Myers, Beisi Xu, Kaeli M. Mathias, Emma C. Beane, Sandi Radko-Juettner, et al.From:Molecular Cell (Vol. 82, Issue 13) Peer-Reviewed

  July 7, 2022463 words Report

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• Select Mitochondrial and nuclear genomic responses to loss of LRPPRC expression

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  Mitochondrial and nuclear genomic responses to loss of LRPPRC expression

  Authors:Vishal M. Gohil*, Roland Nilsson, Casey A. Belcher-Timme, Biao Luo, David E. Root, and Vamsi K. MoothaFrom:Mitochondrion (Vol. 11, Issue 4) Peer-Reviewed

  July 201129 words Article

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• Select Genome-scale CRISPR-Cas9 knockout screening in human cells

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  Genome-scale CRISPR-Cas9 knockout screening in human cells

  Authors:Ophir Shalem, Neville E. Sanjana, Ella Hartenian, Xi Shi, David A. Scott, Tarjei S. Mikkelsen, et al.From:Science (Vol. 343, Issue 6166) Peer-Reviewed

  Jan. 3, 2014152 words Author abstract, Rep...

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• Select High-throughput Phenotyping of Lung Cancer Somatic Mutations.

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  High-throughput Phenotyping of Lung Cancer Somatic Mutations.

  Authors:Alice H. Berger, Angela N. Brooks, Xiaoyun Wu, Yashaswi Shrestha, Candace Chouinard, Federica Piccioni, et al.From:Cancer Cell (Vol. 30, Issue 2) Peer-Reviewed

  Aug. 8, 2016425 words Article

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• Select Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses

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  Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses

  Authors:Ido Amit, Manuel Garber, Nicolas Chevrier, Ana Paula Leite, Yoni Donner, Thomas Eisenhaure, et al.From:Science (Vol. 326, Issue 5950) Peer-Reviewed

  Oct. 9, 2009126 words Author abstract, Rep...

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• Select Broad-band Poly-Harmonic Distortion (PHD) behavioral models from fast automated simulations and large-signal vectorial network measurements

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  Broad-band Poly-Harmonic Distortion (PHD) behavioral models from fast automated simulations and large-signal vectorial network measurements

  Authors:David E. Root, Jan Verspecht, David Sharrit, John Wood, and Alex CognataFrom:IEEE Transactions on Microwave Theory and Techniques (Vol. 53, Issue 11) Peer-Reviewed

  Nov. 2005177 words Author abstract

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• Select Synergistic interactions with PI3K inhibition that induce apoptosis

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  Synergistic interactions with PI3K inhibition that induce apoptosis

  Authors:Yaara Zwang, Oliver Jonas, Casandra Chen, Mikael L Rinne, John G Doench, Federica Piccioni, et al.From:eLife (Vol. 6) Peer-Reviewed

  May 31, 201714,863 words Article 1450LActivating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit...
• Select Resources for the design of CRISPR gene editing experiments

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  Resources for the design of CRISPR gene editing experiments

  Authors:Daniel B. Graham and David E. RootFrom:Genome Biology (Vol. 16, Issue 1) Peer-Reviewed

  Nov. 27, 201511,758 words Article 1580LCRISPR-based approaches have quickly become a favored method to perturb genes to uncover their functions. Here, we review the key considerations in the design of genome editing experiments, and survey the tools and...
• Select ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens

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  ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens

  Authors:Jill P. Mesirov, William C. Hahn, David E. Root, Adam A. Margolin, Levi A. Garraway, Rameen Beroukhim, et al.From:Genome Research (Vol. 23, Issue 4) Peer-Reviewed

  Apr. 2013 Report

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• Select MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

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  MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

  Authors:Gregory V. Kryukov, Frederick H. Wilson, Jason R. Ruth, Joshiawa Paulk, Aviad Tshemiak, Sara E. Marlow, et al.From:Science (Vol. 351, Issue 6278) Peer-Reviewed

  Mar. 11, 2016150 words Author abstract, Rep...

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• Select Rational design of highly active sgRNAs for CRISPR-cas9-mediated gene inactivation

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  Rational design of highly active sgRNAs for CRISPR-cas9-mediated gene inactivation

  Authors:John G. Doench, Ella Hartenian, Daniel B. Graham, Zuzana Tothova, Mudra Hegde, Ian Smith, et al.From:Nature Biotechnology (Vol. 32, Issue 12) Peer-Reviewed

  Dec. 20145,727 words Letter to the editor... 1490LComponents of the prokaryotic clustered, regularly interspaced, short palindromic repeats (CRISPR) loci have recently been repurposed for use in mammalian cells (1-6). The CRISPR-associated (Cas) (9) can be programmed...
• Select Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.

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  Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.

  Authors:Michelle Dang, Nicole Armbruster, Miles A. Miller, Efrain Cermeno, Monika Hartmann, George W. Bell, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 110, Issue 24) Peer-Reviewed

  June 11, 2013173 words Report, Author abstr...

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• Select An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.

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  An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.

  Authors:Matthieu Giraud, Nada Jmari, Lina Du, Floriane Carallis, Thomas J.F. Nieland, Flor M. Perez-Campo, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 111, Issue 4) Peer-Reviewed

  Jan. 28, 2014247 words Report, Author abstr...

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• Select A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration

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  A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration

  Authors:Gromoslaw A. Smolen, Jianmin Zhang, Matthew J. Zubrowski, Elena J. Edelman, Biao Luo, Min Yu, et al.From:Genes & Development (Vol. 24, Issue 23) Peer-Reviewed

  Dec. 1, 2010 Report

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• Select CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2

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  CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2

  Authors:Liying Chen, Gabriela Alexe, Neekesh V. Dharia, Linda Ross, Amanda Balboni Iniguez, Amy Saur Conway, et al.From:Journal of Clinical Investigation (Vol. 128, Issue 1) Peer-Reviewed

  Jan. 201810,086 words Article 1440LPharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma, amplification of the oncogene MYCN is associated with...
• Select Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models

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  Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models

  Authors:Silvestre Vicent, Ron Chen, Leanne C. Sayles, Chenwei Lin, Randal G. Walker, Anna K. Gillespie, et al.From:Journal of Clinical Investigation (Vol. 120, Issue 11) Peer-Reviewed

  Nov. 20107,771 words Report 1400LKRAS is one of the most frequently mutated human oncogenes. In some settings, oncogenic KRAS can trigger cellular senescence, whereas in others it produces hyperproliferation. Elucidating the mechanisms regulating these...
• Select A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

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  A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

  Authors:Mehmet Gonen, Barbara A. Weir, Glenn S. Cowley, Francisca Vazquez, Yuanfang Guan, Alok Jaiswal, et al.From:Cell Systems (Vol. 5, Issue 5) Peer-Reviewed

  Nov. 22, 2017895 words Author abstract, Rep...

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• Select Aire-dependent genes undergo Clp1-mediated 3'UTR shortening associated with higher transcript stability in the thymus.

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  Aire-dependent genes undergo Clp1-mediated 3'UTR shortening associated with higher transcript stability in the thymus.

  Authors:Clotilde Guyon, Nada Jmari, Francine Padonou, Yen-Chin Li, Olga Ucar, Noriyuki Fujikado, et al.From:eLife (Vol. 9) Peer-Reviewed

  Apr. 29, 202020,960 words Article 1620LThe ability of the immune system to avoid autoimmune disease relies on tolerization of thymocytes to self-antigens whose expression and presentation by thymic medullary epithelial cells (mTECs) is controlled...
• Select Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

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  Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

  Authors:Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, et al.From:eLife (Vol. 6) Peer-Reviewed

  Feb. 8, 201719,716 words Report 1540LGenomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes...
• Select Spectroscopy of binuclear dioxygen complexes

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  Spectroscopy of binuclear dioxygen complexes

  Authors:Edward I. Solomon, Felix Tuczek, David E. Root, and Carl A. BrownFrom:Chemical Reviews (Vol. 94, Issue 3) Peer-Reviewed

  May 199476 words Article

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