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    Academic Journals

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• Long term intrinsic cycling in human life course antibody responses to influenza A(H3N2): an observational and modeling study.

  Authors:Bingyi Yang, Bernardo García-Carreras, Justin Lessler, Jonathan M Read, Huachen Zhu, C Jessica E Metcalf, et al.From:eLife (Vol. 11) Peer-Reviewed

  Dec. 2, 202215,409 words Report 1520LBackground: Over a life course, human adaptive immunity to antigenically mutable pathogens exhibits competitive and facilitative interactions. We hypothesize that such interactions may lead to cyclic dynamics in immune...

• Influenza A virus transmission in swine farms and during transport in the swine supply chain.

  Authors:Jonathan Tin Lai Cheung, Eric HY Lau, Ziying Jin, Huachen Zhu, Yi Guan, and Malik PeirisFrom:Transboundary and Emerging Diseases (Vol. 69, Issue 5) Peer-Reviewed

  Sept. 2022368 words Report, Brief articl...

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• Using serological measures to estimate influenza incidence in the presence of secular trends in exposure and immuno-modulation of antibody response.

  Authors:Talia M. Quandelacy, Derek A. T. Cummings, Chao Qiang Jiang, Bingyi Yang, Kin On Kwok, Byran Dai, et al.From:Influenza and Other Respiratory Viruses (Vol. 15, Issue 2) Peer-Reviewed

  Mar. 2021325 words Report, Brief articl...

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• Life course exposures continually shape antibody profiles and risk of seroconversion to influenza.

  Authors:Bingyi Yang, Justin Lessler, Huachen Zhu, Chao Qiang Jiang, Jonathan M. Read, James A. Hay, et al.From:PLoS Pathogens (Vol. 16, Issue 7) Peer-Reviewed

  July 23, 202010,058 words Report 1510LComplex exposure histories and immune mediated interactions between influenza strains contribute to the life course of human immunity to influenza. Antibody profiles can be generated by characterizing immune responses to...

• Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus

  Authors:Sun-Woo Yoon, Sook-San Wong, Huachen Zhu, Rirong Chen, and Long LiFrom:Journal of Infectious Diseases (Vol. 217, Issue 3) Peer-Reviewed

  Feb. 1, 2018 Article

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• Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013--17: an epidemiological study of laboratory-confirmed case series

  Authors:Xiling Wang, Hui Jiang, Peng Wu, Timothy M Uyeki, Luzhao Feng, Shengjie Lai, et al.From:The Lancet Infectious Diseases (Vol. 17, Issue 8) Peer-Reviewed

  Aug. 2017948 words Article

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• Use of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypes

  Authors:Alex W. H. Chin, Chris K. P. Mok, Huachen Zhu, Yi Guan, Joseph S. M. Peiris, and Leo L. M. PoonFrom:Influenza and Other Respiratory Viruses (Vol. 8, Issue 5) Peer-Reviewed

  Sept. 2014160 words Article

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• Dissemination, divergence and establishment of H7N9 influenza viruses in China

  Authors:Tommy Tsan-Yuk Lam, Boping Zhou, Jia Wang, Yujuan Chai, Yongyi Shen, Xinchun Chen, et al.From:Nature (Vol. 522, Issue 7544) Peer-Reviewed

  June 4, 20154,244 words Report 1520LSince 2013 the occurrence of human infections by a novel avian H7N9 influenza virus in China has demonstrated the continuing threat posed by zoonotic pathogens (1,2). Although the first outbreak wave that was centred on...

• Possible role of songbirds and parakeets in transmission of influenza A (H7N9) virus to humans

  Authors:Jeremy C. Jones, Stephanie Sonnberg, Zeynep A. Koger, Karthik Shanmuganatham, Patrick Seiler, Yuelong Shu, et al.From:Emerging Infectious Diseases (Vol. 20, Issue 3) Peer-Reviewed

  Mar. 20144,071 words Report 1450LAvian-origin influenza A(H7N9) recently emerged in China, causing severe human disease. Several subtype H7N9 isolates contain influenza genes previously identified in viruses from finch-like birds. Because wild and...

• Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19.

  Authors:Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma, Rirong Chen, Liuqin Yu, et al.From:Protein & Cell (Vol. 13, Issue 1) Peer-Reviewed

  Jan. 2022126 words Brief article

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• Molecular detection of human H7N9 influenza A virus causing outbreaks in China

  Authors:Chloe K.S. Wong, Huachen Zhu, Olive T.W. Li, Yin Hung C. Leung, Michael C.W. Chan, Yi Guan, et al.From:Clinical Chemistry (Vol. 59, Issue 7) Peer-Reviewed

  July 20133,141 words Report 1450L

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• Estimating the life course of influenza A (H3N2) antibody responses from cross-sectional data

  Authors:Adam J. Kucharski, Justin Lessler, Jonathan M. Read, Huachen Zhu, Chao Qiang Jiang, Yi Guan, et al.From:PLoS Biology (Vol. 13, Issue 3) Peer-Reviewed

  Mar. 20157,342 words Report 1410LThe immunity of a host population against specific influenza A strains can influence a number of important biological processes, from the emergence of new virus strains to the effectiveness of vaccination programmes....

• Long-term evolution and transmission dynamics of swine influenza a virus

  Authors:Dhanasekaran Vijaykrishna, Gavin J.D. Smith, Oliver G. Pybus, Huachen Zhu, Samir Bhatt, Leo L.M. Poon, et al.From:Nature (Vol. 473, Issue 7348) Peer-Reviewed

  May 26, 20114,459 words Clinical report 1500LSwine influenza A viruses (SwIV) cause significant economic losses in animal husbandry as well as instances of human disease1 and occasionally give rise to human pandemics (2), including that caused by the H1N1/2009...

• A field‐deployable insulated isothermal RT‐PCR assay for identification of influenza A (H7N9) shows good performance in the laboratory.

  Authors:Ken Inui, Tung Nguyen, Hsin&#8208 Tseng, Jou, Chuanfu Mark Tsai, Yun&#8208 Tsai, et al.From:Influenza and Other Respiratory Viruses (Vol. 13, Issue 6) Peer-Reviewed

  Sept. 5, 20194,611 words Report 1600LAbstract: Background: Avian influenza A (H7N9) remains circulating in China. For countries at risk of introduction of H7N9, such as Vietnam, early detection of H7N9 virus is essential for the early containment of the...

• A field-deployable insulated isothermal RT-PCR assay for identification of influenza A (H7N9) shows good performance in the laboratory.

  Authors:Ken Inui, Tung Nguyen, Hsin-Jou Tseng, ChuanFu Mark Tsai, Yun-Long Tsai, Simon Chung, et al.From:Influenza and Other Respiratory Viruses (Vol. 13, Issue 6) Peer-Reviewed

  Nov. 2019284 words Report, Brief articl...

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• A comparison of hemagglutination inhibition and neutralization assays for characterizing immunity to seasonal influenza A.

  Authors:Shaun Truelove, Huachen Zhu, Justin Lessler, Steven Riley, Jonathan M. Read, Shuying Wang, et al.From:Influenza and Other Respiratory Viruses (Vol. 10, Issue 6) Peer-Reviewed

  July 12, 20164,514 words Article 1510LBackground: Serum antibody to influenza can be used to identify past exposure and measure current immune status. The two most common methods for measuring this are the hemagglutination inhibition assay (HI) and the...

• Using serological measures to estimate influenza incidence in the presence of secular trends in exposure and immuno‐modulation of antibody response.

  Authors:Talia M. Quandelacy, Derek A.T. Cummings, Chao Qiang Jiang, Bingyi Yang, Kin On Kwok, Byran Dai, et al.From:Influenza and Other Respiratory Viruses (Vol. 15, Issue 2) Peer-Reviewed

  Oct. 27, 20205,304 words Report 1560LAbstract: Background: Influenza infection is often measured by a fourfold antibody titer increase over an influenza season (ie seroconversion). However, this approach may fail when influenza seasons are less distinct...

• Safety and immunogenicity of an 8 year interval heterologous prime-boost influenza A/H7N7-H7N9 vaccination

  Authors:Hana M. El Sahly, Robert L. Atmar, Shital M. Patel, Abbie Bellamy, Liwei Liu, Wenshan Hong, et al.From:Vaccine (Vol. 37, Issue 19) Peer-Reviewed

  May 1, 2019434 words Article

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• Specificity, kinetics and longevity of antibody responses to avian influenza A(H7N9) virus infection in humans

  Authors:Junbo Chen, Huachen Zhu, Peter W. Horby, Qianli Wang, Jiaxin Zhou, Hui Jiang, et al.From:Journal of Infection (Vol. 80, Issue 3) Peer-Reviewed

  Mar. 2020481 words Clinical report

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• The genesis and source of the H7N9 influenza viruses causing human infections in China

  Authors:Tommy Tsan-Yuk Lam, Jia Wang, Yongyi Shen, Boping Zhou, Lian Duan, Chung-Lam Cheung, et al.From:Nature (Vol. 502, Issue 7470) Peer-Reviewed

  Oct. 10, 20135,254 words Report 1510LA novel H7N9 influenza A virus first detected in March 2013 has since caused more than 130 human infections in China, resulting in 40 deaths (1,2). Preliminary analyses suggest that the virus is a reassortant of H7, N9...