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- 3From:Journal of Pediatric Ophthalmology & Strabismus (Issue 57) Peer-ReviewedA 4-month-old male infant with frontometaphyseal dysplasia and de novo FLNA gene mutation died of complications of disease. Post-mortem examination revealed accessory iris membranes. This is the first report in the...
- 4From:Nature Medicine (Vol. 19, Issue 9) Peer-ReviewedForkhead box P3 [(Foxp3).sup.+] T regulatory ([T.sub.reg]) cells maintain immune homeostasis and limit autoimmunity but can also curtail host immune responses to various types of tumors (1), (2). [Foxp3.sup.+]...
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- 7From:Journal of Clinical Investigation (Vol. 130, Issue 12) Peer-ReviewedThe transcription factor MEF2D is important in the regulation of differentiation and adaptive responses in many cell types. We found that among T cells, MEF2D gained new functions in [Foxp3.sup.+] T regulatory (Treg)...
- 8From:Journal of Clinical Investigation (Vol. 125, Issue 3) Peer-ReviewedTreg dysfunction is associated with a variety of inflammatory diseases. Treg populations are defined by expression of the oligomeric transcription factor FOXP3 and inability to produce IL-2, a cytokine required for T...
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- 15From:PLoS ONE (Vol. 7, Issue 6) Peer-ReviewedBackground Kawasaki disease is recognized as the most common cause of acquired heart disease in children in the developed world. Clinical, epidemiologic, and pathologic evidence supports an infectious agent, likely...
- 16From:Journal of Clinical Investigation (Vol. 126, Issue 5) Peer-ReviewedExperimentally, females show an improved ability to recover from ischemia- reperfusion injury (IRI) compared with males; however, this sex-dependent response is less established in humans. Here, we developed a series of...
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