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    Academic Journals

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• Select Progress toward an amplifiable metabolic label for DNA: conversion of 4-thiothymidine (4sT) to 5-methyl-2=-deoxycytidine and synthesis of a 4sT phosphorodiamidate prodrug

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  Progress toward an amplifiable metabolic label for DNA: conversion of 4-thiothymidine (4sT) to 5-methyl-2=-deoxycytidine and synthesis of a 4sT phosphorodiamidate prodrug

  Authors:Adam K. Hedger, Marlies E. Oomen, Victor Liu, Michael P. Moazami, Nicholas Rhind, Job Dekker, et al.From:Canadian Journal of Chemistry (Vol. 96, Issue 7) Peer-Reviewed

  July 20186,622 words Report 1620LThe ability to metabolically label DNA in a way that produces a latent change from one nucleobase to another would create asignal that can beamplified by PCR--this in turn would allow studies of newly synthesized DNA...
• Select Enhancer RNA Facilitates NELF Release from Immediate Early Genes

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  Enhancer RNA Facilitates NELF Release from Immediate Early Genes

  Authors:Katie Schaukowitch, Jae-Yeol Joo, Xihui Liu, Jonathan K. Watts, Carlos Martinez, and Tae-Kyung KimFrom:Molecular Cell (Vol. 56, Issue 1) Peer-Reviewed

  Oct. 2, 2014245 words Article

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• Select 2'F-arabinonucleic acids (2'F-ANA)--history, properties, and new frontiers

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  2'F-arabinonucleic acids (2'F-ANA)--history, properties, and new frontiers

  Authors:Jonathan K. Watts and Masad J. DamhaFrom:Canadian Journal of Chemistry (Vol. 86, Issue 7) Peer-Reviewed

  July 200811,814 words Report 1470LAbstract: The development of arabinonucleosides and oligoarabinonucleotides is described, focusing especially on 2'-deoxy-2'-fluoroarabinonucleosides (araF-N) and -oligonucleotides (2T-ANA). In addition to their...
• Select Jesus Christ and the Life of the Mind

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  Jesus Christ and the Life of the Mind

  Author:Jonathan K. WattsFrom:Perspectives on Science and Christian Faith (Vol. 64, Issue 4) Peer-Reviewed

  Dec. 20121,157 words Book review 1260LJESUS CHRIST AND THE LIFE OF THE MIND by Mark A. Noll. Grand Rapids, MI: Eerdmans, 2011. 180 pages. Hardcover; $25.00. ISBN: 9780802866370. A number of thorny issues confront Christians who wish to pursue serious...
• Select Detecting chromatin interactions between and along sister chromatids with SisterC.

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  Detecting chromatin interactions between and along sister chromatids with SisterC.

  Authors:Marlies E. Oomen, Adam K. Hedger, Jonathan K. Watts, and Job DekkerFrom:Nature Methods (Vol. 17, Issue 10) Peer-Reviewed

  Oct. 20209,465 words Article 1540LChromosome segregation requires both compaction and disentanglement of sister chromatids. We describe SisterC, a chromosome conformation capture assay that distinguishes interactions between and along identical sister...
• Select Generation of Novel Hybrid Aptamer-Molecularly Imprinted Polymeric Nanoparticles

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  Generation of Novel Hybrid Aptamer-Molecularly Imprinted Polymeric Nanoparticles

  Authors:Alessandro Poma, Heli Brahmbhatt, Hannah M. Pendergraff, Jonathan K. Watts, and Nicholas W. TurnerFrom:Advanced Materials (Vol. 27, Issue 4) Peer-Reviewed

  Jan. 27, 2015101 words Report

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• Select Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates

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  Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates

  Authors:Keith T. Gagnon, Jonathan K. Watts, Hannah M. Pendergraff, Christophe Montaillier, Danielle Thai, Pierre Potier, et al.From:Journal of the American Chemical Society (Vol. 133, Issue 22) Peer-Reviewed

  June 8, 201159 words Report

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• Select Generation of Novel Hybrid Aptamer-Molecularly Imprinted Polymeric Nanoparticles

  8

  Generation of Novel Hybrid Aptamer-Molecularly Imprinted Polymeric Nanoparticles

  Authors:Alessandro Poma, Heli Brahmbhatt, Hannah M. Pendergraff, Jonathan K. Watts, and Nicholas W. TurnerFrom:Advanced Materials (Vol. 27, Issue 9) Peer-Reviewed

  Mar. 4, 201523 words Report

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• Select Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs

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  Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs

  Authors:Jiaxin Hu, Keith T. Gagnon, Jing Liu, Jonathan K. Watts, Jeja Syeda-Nawaz, C. Frank Bennett, et al.From:Biological Chemistry (Vol. 392, Issue 4) Peer-Reviewed

  Apr. 2011182 words Report 1400L

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• Select Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-Quadruplexes.

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  Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-Quadruplexes.

  Authors:David A. Price, Zachary J. Kartje, Joanna A. Hughes, Tayler D. Hill, Taylor M. Loth, Jonathan K. Watts, et al.From:ChemBioChem (Vol. 21, Issue 19) Peer-Reviewed

  Oct. 1, 2020248 words Report, Brief articl...

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• Select Hybrid Aptamer-Molecularly Imprinted Polymer (aptaMIP) Nanoparticles from Protein Recognition-A Trypsin Model.

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  Hybrid Aptamer-Molecularly Imprinted Polymer (aptaMIP) Nanoparticles from Protein Recognition-A Trypsin Model.

  Authors:Mark V. Sullivan, Oliver Clay, Michael P. Moazami, Jonathan K. Watts, and Nicholas W. TurnerFrom:Macromolecular Bioscience (Vol. 21, Issue 5) Peer-Reviewed

  May 2021225 words Report, Brief articl...

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• Select Biological information, molecular structure, and the origins debate

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  Biological information, molecular structure, and the origins debate

  Author:Jonathan K. WattsFrom:Perspectives on Science and Christian Faith (Vol. 63, Issue 4) Peer-Reviewed

  Dec. 20115,860 words Essay 1490LBiomolecules contain tremendous amounts of information; this information is "written" and "read" through their chemical structures and functions. A change in the information of a biomolecule is a change in the physical...
• Select The chemical evolution of oligonucleotide therapies of clinical utility

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  The chemical evolution of oligonucleotide therapies of clinical utility

  Authors:Anastasia Khvorova and Jonathan K WattsFrom:Nature Biotechnology (Vol. 35, Issue 3) Peer-Reviewed

  Mar. 20179,643 words Report 1510LAfter nearly 40 years of development, oligonucleotide therapeutics are nearing meaningful clinical productivity. One of the key advantages of oligonucleotide drugs is that their delivery and potency are derived...
• Select Synthesis and biophysical characterization of oligonucleotides containing a 4'-selenonucleotide

  14

  Synthesis and biophysical characterization of oligonucleotides containing a 4'-selenonucleotide

  Authors:Jonathan K. Watts, Blair D. Johnston, Kumarasamy Jayakanthan, Alexander S. Wahba, B. Mario Pinto, and Masad J. DamhaFrom:Journal of the American Chemical Society (Vol. 130, Issue 27) Peer-Reviewed

  July 9, 200827 words Article

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• Select Component analysis of the X-C-Y anomeric effect (X = O, S; Y = F, OMe, NHMe) by DFT molecular orbital calculations and natural bond orbital analysis (1)

  15

  Component analysis of the X-C-Y anomeric effect (X = O, S; Y = F, OMe, NHMe) by DFT molecular orbital calculations and natural bond orbital analysis (1)

  Authors:Melissa L. Trapp, Jonathan K. Watts, Noham Weinberg, and B. Mario PintoFrom:Canadian Journal of Chemistry (Vol. 84, Issue 4) Peer-Reviewed

  Apr. 20065,441 words Article 1710LSix 2-Y-substituted oxacyclohexane and thiacyclohexane heterocycles (Y = F, OMe, NHMe) were examined using DFT molecular orbital calculations. Natural bond orbital (NBO) analysis of the total energy behaviour yielded...
• Select Energetically important C-H...F-C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity

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  Energetically important C-H...F-C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity

  Authors:Maryam Yahyaee Anzahaee, Jonathan K. Watts, Nageswara R. Alla, Allen W. Nicholson, and Masad J. DamhaFrom:Journal of the American Chemical Society (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 2, 201140 words Report

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• Select Clinical status of duplex RNA

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  Clinical status of duplex RNA

  Authors:Jonathan K. Watts and David R. CoreyFrom:Bioorganic & Medicinal Chemistry Letters (Vol. 20, Issue 11) Peer-Reviewed

  June 1, 201068 words Article

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• Select 5'-Modifications improve potency and efficacy of DNA donors for precision genome editing.

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  5'-Modifications improve potency and efficacy of DNA donors for precision genome editing.

  Authors:Krishna S Ghanta, Zexiang Chen, Aamir Mir, Gregoriy A Dokshin, Pranathi M Krishnamurthy, Yeonsoo Yoon, et al.From:eLife (Vol. 10) Peer-Reviewed

  Oct. 19, 202113,593 words Article 1460LNuclease-directed genome editing is a powerful tool for investigating physiology and has great promise as a therapeutic approach to correct mutations that cause disease. In its most precise form, genome editing can use...
• Select Chemically modified siRNA: tools and applications

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  Chemically modified siRNA: tools and applications

  Authors:Jonathan K. Watts, Glen F. Deleavey, and Masad J. DamhaFrom:Drug Discovery Today (Vol. 13, Issue 19-20) Peer-Reviewed

  Oct. 2008103 words Report

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• Select Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU)

  20

  Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU)

  Authors:Jonathan K. Watts, Kashinath Sadalapure, Niloufar Choubdar, and Masad J. DamhaFrom:Journal of Organic Chemistry (Vol. 71, Issue 3) Peer-Reviewed

  Feb. 3, 200644 words Article

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