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    Academic Journals

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• A novel view on the pathogenesis of complications after intravesical BCG for bladder cancer

  Authors:Manu P. Bilsen, Krista E. van Meijgaarden, Hanna K. de Jong, Simone A. Joosten, Corine Prins, Lucia J.M. Kroft, et al.From:International Journal of Infectious Diseases (Vol. 72) Peer-Reviewed

  July 2018431 words Report

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• Longitudinal immune profiles in type 1 leprosy reactions in Bangladesh, Brazil, Ethiopia and Nepal

  Authors:Saraswoti Khadge, Sayera Banu, Kidist Bobosha, Jolien J. van der Ploeg-van Schip, Isabela M. Goulart, Pratibha Thapa, et al.From:BMC Infectious Diseases (Vol. 15, Issue 1) Peer-Reviewed

  Oct. 28, 20156,569 words Article 1550LBackground Acute inflammatory reactions are a frequently occurring, tissue destructing phenomenon in infectious- as well as autoimmune diseases, providing clinical challenges for early diagnosis. In leprosy, an...

• Tuberculin skin testing and in vitro T cell responses to ESAT-6 and culture filtrate protein 10 after infection with Mycobacterium marinum or M. kansasii

  Authors:Sandra M. Arend, Krista E. van Meijgaarden, Kirsten de Boer, Elisabeth Cerda de Palou, Dick van Soolingen, Tom H.M. Ottenhoff, et al.From:Journal of Infectious Diseases (Vol. 186, Issue 12) Peer-Reviewed

  Dec. 15, 2002 Article

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• [CD8.sup.+] regulatory T cells, and not [CD4.sup.+] T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells

  Authors:Mardi C. Boer, Krista E. van Meijgaarden, Simone A. Joosten, and Tom H.M. OttenhoffFrom:PLoS ONE (Vol. 9, Issue 4) Peer-Reviewed

  Apr. 20144,799 words Report 1430LMycobacterium bovis bacillus Calmette-Guerin (M. bovis BCG), the only currently available vaccine against tuberculosis, has been reported to induce regulatory T cells in humans. The activity of regulatory T cells may...

• Identification of a human [CD8.sup.+] regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4

  Authors:Simone A. Joosten, Krista E. van Meijgaarden, Nigel D.L. Savage, Tjitske de Boer, Frederic Triebel, Annemieke van der Wal, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 104, Issue 19) Peer-Reviewed

  May 8, 2007108 words Author abstract

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• Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment

  Authors:Simone A. Joosten, Krista E. van Meijgaarden, Franca del Nonno, Andrea Baiocchini, Linda Petrone, Valentina Vanini, et al.From:PLoS Pathogens (Vol. 12, Issue 6) Peer-Reviewed

  June 15, 201611,601 words Report 1500LB-cells not only produce immunoglobulins and present antigens to T-cells, but also additional key roles in the immune system. Current knowledge on the role of B-cells in infections caused by intracellular bacteria is...

• Differences in IgG responses against infection phase related Mycobacterium tuberculosis (Mtb) specific antigens in individuals exposed or not to Mtb correlate with control of TB infection and progression

  Authors:Mariateresa Coppola, Leonar Arroyo, Krista E. van Meijgaarden, Kees LMC. Franken, Annemieke Geluk, Luis F. Barrera, et al.From:Tuberculosis (Vol. 106) Peer-Reviewed

  Sept. 2017326 words Report

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• Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

  Authors:Steven G. Smith, Kaatje Smits, Simone A. Joosten, Krista E. van Meijgaarden, Iman Satti, Helen A. Fletcher, et al.From:PLoS ONE (Vol. 10, Issue 9) Peer-Reviewed

  Sept. 14, 20158,297 words Article 1620LIntracellular cytokine staining combined with flow cytometry is one of a number of assays designed to assess T-cell immune responses. It has the specific advantage of enabling the simultaneous assessment of multiple...

• Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human [CD8.sup.+] T-cells with cytotoxic as well as regulatory activity

  Authors:Simone A. Joosten, Krista E. van Meijgaarden, Pascale C. van Weeren, Fatima Kazi, Annemieke Geluk, Nigel D.L. Savage, et al.From:PLoS Pathogens (Vol. 6, Issue 2) Peer-Reviewed

  Feb. 201011,107 words Report Tuberculosis (TB) is an escalating global health problem and improved vaccines against TB are urgently needed. HLA-E restricted responses may be of interest for vaccine development since HLA-E displays very limited...

• Altered Peptide Ligands of Islet Autoantigen Imogen 38 Inhibit Antigen Specific T Cell Reactivity in Human Type-1 Diabetes

  Authors:Annemieke Geluk, Krista E. Van Meijgaarden, Bart O. Roep, and Tom H.M OttenhoffFrom:Journal of Autoimmunity (Vol. 11, Issue 4) Peer-Reviewed

  Aug. 1998272 words Article

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• Mycobacterial growth inhibition is associated with trained innate immunity

  Authors:Simone A. Joosten, Krista E. van Meijgaarden, Sandra M. Arend, Corine Prins, Fredrik Oftung, Gro Ellen Korsvold, et al.From:Journal of Clinical Investigation (Vol. 128, Issue 5) Peer-Reviewed

  May 201810,430 words Article 1420LThe lack of defined correlates of protection hampers development of vaccines against tuberculosis (TB). In vitro mycobacterial outgrowth assays are thought to better capture the complexity of the human...

• Human [CD8.sup.+] T-cells recognizing peptides from mycobacterium tuberculosis (Mtb) presented by HLA-E have an Unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset

  Authors:Krista E. van Meijgaarden, Marielle C. Haks, Nadia Caccamo, Francesco Dieli, Tom H.M. Ottenhoff, and Simone A. JoostenFrom:PLoS Pathogens (Vol. 11, Issue 3) Peer-Reviewed

  Mar. 201510,789 words Report 1590LMycobacterial antigens are not exclusively presented to T-cells by classical HLA-class Ia and HLA-class II molecules, but also through alternative antigen presentation molecules such as CD1a/b/c, MR1 and HLA-E. We...

• T-cell regulation in lepromatous leprosy

  Authors:Kidist Bobosha, Louis Wilson, Krista E. van Meijgaarden, Yonas Bekele, Martha Zewdie, Jolien J. van der Ploeg-van Schip, et al.From:PLoS Neglected Tropical Diseases (Vol. 8, Issue 4) Peer-Reviewed

  Apr. 20147,429 words Report 1550LRegulatory T ([T.sub.reg]) cells are known for their role in maintaining self- tolerance and balancing immune reactions in autoimmune diseases and chronic infections. However, regulatory mechanisms can also lead to...

• Immunological characterization of latent tuberculosis infection in a low endemic country

  Authors:Roelof A. de Paus, Krista E. van Meijgaarden, Corine Prins, Margreet H. Kamphorst, Sandra M. Arend, Tom H.M. Ottenhoff, et al.From:Tuberculosis (Vol. 106) Peer-Reviewed

  Sept. 2017316 words Report

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• Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies

  Authors:Krista E. van Meijgaarden, Bhagwati Khatri, Steven G. Smith, Anne M. F. H. Drittij, Roelof A. de Paus, Jelle J. Goeman, et al.From:PLoS ONE (Vol. 13, Issue 9) Peer-Reviewed

  Sept. 4, 20187,740 words Report 1570LBackground Multiplex assays are increasingly applied to analyze multicomponent signatures of human immune responses, including the dynamics of cytokine and chemokine production, in observational as well as...

• Clonal Analysis of the T-Cell Response to In Vivo Expressed Mycobacterium tuberculosis Protein Rv2034, Using a CD154 Expression Based T-Cell Cloning Method

  Authors:Susanna Commandeur, Mariateresa Coppola, Karin Dijkman, Annemieke H. Friggen, Krista E. van Meijgaarden, Susan J. F. van den Eeden, et al.From:PLoS ONE (Vol. 9, Issue 6) Peer-Reviewed

  June 6, 20149,979 words Article 1450LTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of death worldwide. A better understanding of the role of CD4.sup.+ and CD8.sup.+ T cells, which are both important to TB...

• Optimisation, harmonisation and standardisation of the direct mycobacterial growth inhibition assay using cryopreserved human peripheral blood mononuclear cells

  Authors:Rachel Tanner, Steven G. Smith, Krista E. van Meijgaarden, Federico Giannoni, Morven Wilkie, Lucia Gabriele, et al.From:Journal of Immunological Methods (Vol. 469) Peer-Reviewed

  June 2019425 words Report

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