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    Academic Journals

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• Antigen presentation by MHC-E: a putative target for vaccination?

  Authors:Linda Voogd, Paula Ruibal, Tom H.M. Ottenhoff, and Simone A. JoostenFrom:Trends in Immunology (Vol. 43, Issue 5) Peer-Reviewed

  May 2022319 words Report, Brief articl...

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• Applying the FAIR principles to data in a hospital: challenges and opportunities in a pandemic.

  Authors:Núria Queralt-Rosinach, Rajaram Kaliyaperumal, César H. Bernabé, Qinqin Long, Simone A. Joosten, Henk Jan van der Wijk, et al.From:Journal of Biomedical Semantics (Vol. 13, Issue 1) Peer-Reviewed

  Apr. 25, 202211,784 words Report 1520LBackground The COVID-19 pandemic has challenged healthcare systems and research worldwide. Data is collected all over the world and needs to be integrated and made available to other researchers quickly. However, the...

• A novel view on the pathogenesis of complications after intravesical BCG for bladder cancer

  Authors:Manu P. Bilsen, Krista E. van Meijgaarden, Hanna K. de Jong, Simone A. Joosten, Corine Prins, Lucia J.M. Kroft, et al.From:International Journal of Infectious Diseases (Vol. 72) Peer-Reviewed

  July 2018431 words Report

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• MHC Ib molecule Qa-1 presents Mycobacterium tuberculosis peptide antigens to CD8.sup.+ T cells and contributes to protection against infection

  Authors:Yao Bian, Shaobin Shang, Sarah Siddiqui, Jie Zhao, Simone A. Joosten, Tom H. M. Ottenhoff, et al.From:PLoS Pathogens (Vol. 13, Issue 5) Peer-Reviewed

  May 5, 201710,970 words Report 1560LA number of nonclassical MHC Ib molecules recognizing distinct microbial antigens have been implicated in the immune response to Mycobacterium tuberculosis (Mtb). HLA-E has been identified to present numerous Mtb...

• Identification of Major Factors Influencing ELISpot-Based Monitoring of Cellular Responses to Antigens from Mycobacterium tuberculosis

  Authors:Steven G. Smith, Simone A. Joosten, Virginie Verscheure, Ansar A. Pathan, Helen McShane, Tom H. M. Ottenhoff, et al.From:PLoS ONE (Vol. 4, Issue 11) Peer-Reviewed

  Nov. 24, 20095,717 words Article 1580LAuthor(s): Steven G. Smith 1,*, Simone A. Joosten 2, Virginie Verscheure 3, Ansar A. Pathan 4, Helen McShane 4, Tom H. M. Ottenhoff 2, Hazel M. Dockrell 1, Françoise Mascart 3,5 Introduction In the absence of any...

• Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines

  Authors:Nadia Caccamo, Gabriella Pietra, Lucy C. Sullivan, Andrew G. Brooks, Teresa Prezzemolo, Marco P. Manna, et al.From:European Journal of Immunology (Vol. 45, Issue 4) Peer-Reviewed

  Apr. 2015458 words Report

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• [CD8.sup.+] regulatory T cells, and not [CD4.sup.+] T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells

  Authors:Mardi C. Boer, Krista E. van Meijgaarden, Simone A. Joosten, and Tom H.M. OttenhoffFrom:PLoS ONE (Vol. 9, Issue 4) Peer-Reviewed

  Apr. 20144,799 words Report 1430LMycobacterium bovis bacillus Calmette-Guerin (M. bovis BCG), the only currently available vaccine against tuberculosis, has been reported to induce regulatory T cells in humans. The activity of regulatory T cells may...

• Identification of a human [CD8.sup.+] regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4

  Authors:Simone A. Joosten, Krista E. van Meijgaarden, Nigel D.L. Savage, Tjitske de Boer, Frederic Triebel, Annemieke van der Wal, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 104, Issue 19) Peer-Reviewed

  May 8, 2007108 words Author abstract

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• Mobilizing unconventional T cells: Modulating unconventional antigen presentation could treat infections and cancer.

  Authors:Tom H.M. Ottenhoff and Simone A. JoostenFrom:Science (Vol. 366, Issue 6463) Peer-Reviewed

  Oct. 18, 20191,978 words Article 1570L

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• Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment

  Authors:Simone A. Joosten, Krista E. van Meijgaarden, Franca del Nonno, Andrea Baiocchini, Linda Petrone, Valentina Vanini, et al.From:PLoS Pathogens (Vol. 12, Issue 6) Peer-Reviewed

  June 15, 201611,601 words Report 1500LB-cells not only produce immunoglobulins and present antigens to T-cells, but also additional key roles in the immune system. Current knowledge on the role of B-cells in infections caused by intracellular bacteria is...

• BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice

  Authors:Andrea D. van Dam, Siroon Bekkering, Malou Crasborn, Lianne van Beek, Susan M. van den Berg, Frank Vrieling, et al.From:Atherosclerosis (Vol. 251) Peer-Reviewed

  Aug. 2016510 words Report

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• Elderly Subjects Have a Delayed Antibody Response and Prolonged Viraemia following Yellow Fever Vaccination: A Prospective Controlled Cohort Study

  Authors:Anna H. Roukens, Darius Soonawala, Simone A. Joosten, Adriette W. de Visser, Xiaohong Jiang, Kees Dirksen, et al.From:PLoS ONE (Vol. 6, Issue 12) Peer-Reviewed

  Dec. 7, 20114,257 words Clinical report 1470LBackground Yellow fever vaccination (YF-17D) can cause serious adverse events (SAEs). The mechanism of these SAEs is poorly understood. Older age has been identified as a risk factor. We tested the hypothesis that...

• Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

  Authors:Steven G. Smith, Kaatje Smits, Simone A. Joosten, Krista E. van Meijgaarden, Iman Satti, Helen A. Fletcher, et al.From:PLoS ONE (Vol. 10, Issue 9) Peer-Reviewed

  Sept. 14, 20158,297 words Article 1620LIntracellular cytokine staining combined with flow cytometry is one of a number of assays designed to assess T-cell immune responses. It has the specific advantage of enabling the simultaneous assessment of multiple...

• A Helicopter Perspective on TB Biomarkers: Pathway and Process Based Analysis of Gene Expression Data Provides New Insight into TB Pathogenesis

  Authors:Simone A. Joosten, Helen A. Fletcher, and Tom H. M. OttenhoffFrom:PLoS ONE (Vol. 8, Issue 9) Peer-Reviewed

  Sept. 16, 20138,613 words Article 1570LBiomarker host genetic signatures are considered key tools for improved early diagnosis of tuberculosis (TB) disease (development). The analysis of gene expression changes based on a limited number of genes or single...

• Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human [CD8.sup.+] T-cells with cytotoxic as well as regulatory activity

  Authors:Simone A. Joosten, Krista E. van Meijgaarden, Pascale C. van Weeren, Fatima Kazi, Annemieke Geluk, Nigel D.L. Savage, et al.From:PLoS Pathogens (Vol. 6, Issue 2) Peer-Reviewed

  Feb. 201011,107 words Report Tuberculosis (TB) is an escalating global health problem and improved vaccines against TB are urgently needed. HLA-E restricted responses may be of interest for vaccine development since HLA-E displays very limited...

• The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

  Authors:Thorbald Van Hall, Claudia C. Oliveira, Simone A. Joosten, and Tom H.M. OttenhoffFrom:Microbes and Infection (Vol. 12, Issue 12-13) Peer-Reviewed

  Nov. 2010117 words Report

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• Identification of Probable Early-Onset Biomarkers for Tuberculosis Disease Progression

  Authors:Jayne S. Sutherland, Philip C. Hill, Ifedayo M. Adetifa, Bouke C. de Jong, Simon Donkor, Simone A. Joosten, et al.From:PLoS ONE (Vol. 6, Issue 9) Peer-Reviewed

  Sept. 23, 20114,992 words Article 1400LDetermining what constitutes protective immunity to TB is critical for the development of improved diagnostics and vaccines. The comparison of the immune system between contacts of TB patients, who later develop TB...

• Mycobacterial growth inhibition is associated with trained innate immunity

  Authors:Simone A. Joosten, Krista E. van Meijgaarden, Sandra M. Arend, Corine Prins, Fredrik Oftung, Gro Ellen Korsvold, et al.From:Journal of Clinical Investigation (Vol. 128, Issue 5) Peer-Reviewed

  May 201810,430 words Article 1420LThe lack of defined correlates of protection hampers development of vaccines against tuberculosis (TB). In vitro mycobacterial outgrowth assays are thought to better capture the complexity of the human...

• Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus

  Authors:Katharina Ronacher, Simone A. Joosten, Reinout Crevel, Hazel M. Dockrell, Gerhard Walzl, and Tom H. M. OttenhoffFrom:Immunological Reviews (Vol. 264, Issue 1) Peer-Reviewed

  Mar. 2015259 words Article

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• Human [CD8.sup.+] T-cells recognizing peptides from mycobacterium tuberculosis (Mtb) presented by HLA-E have an Unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset

  Authors:Krista E. van Meijgaarden, Marielle C. Haks, Nadia Caccamo, Francesco Dieli, Tom H.M. Ottenhoff, and Simone A. JoostenFrom:PLoS Pathogens (Vol. 11, Issue 3) Peer-Reviewed

  Mar. 201510,789 words Report 1590LMycobacterial antigens are not exclusively presented to T-cells by classical HLA-class Ia and HLA-class II molecules, but also through alternative antigen presentation molecules such as CD1a/b/c, MR1 and HLA-E. We...