Showing Results for
- Academic Journals (69)
- 1From:Diabetes (Vol. 72, Issue 2) Peer-Reviewed
An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes.Citation Only
- 2From:Proceedings of the National Academy of Sciences of the United States (Vol. 94, Issue 16) Peer-ReviewedAbstract Only
- 3From:Diabetes Care (Vol. 32, Issue 8) Peer-Reviewed[beta]-Cell replacement therapy's great promise is that it can safely and effectively restore insulin-independent euglycemia to individuals with diabetes. Although difficult and expensive, modern insulin-based treatment...
- 4From:Nature Medicine (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Allan D. Kirk; David M. Harlan Kirk and Harlan reply Kawai and colleagues report a considerable number of thromboembolic events in monkeys after administration of a mouse monoclonal antibody against...
- 5From:Virology Journal (Vol. 6) Peer-ReviewedAuthors: Anthony T Craig [1,2]; Oksana Gavrilova ; Nancy K Dwyer ; William Jou ; Stephanie Pack ; Eric Liu ; Klaus Pechhold ; Michael Schmidt ; Victor J McAlister ; John A Chiorini ; E Joan...
- 6From:Nature Medicine (Vol. 23, Issue 2) Peer-Reviewed
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetesAuthor(s): Jenny Aurielle B Babon; Megan E DeNicola; David M Blodgett; Inne Crèvecoeur; Thomas S Buttrick; René Maehr; Rita Bottino; Ali Naji; John Kaddis; Wassim Elyaman; Eddie A James; Rachana Haliyur; Marcela...
- 7From:Diabetes (Vol. 67, Issue 7) Peer-Reviewed
Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4.sup.+ T Cells in Patients With Type 1 DiabetesCitation Only
- 8From:Journal of Clinical Investigation (Vol. 129, Issue 1) Peer-Reviewed
Human islets expressing HNF1A variant have defective [beta] cell transcriptional regulatory networksUsing an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained [beta] cells without insulitis and...
- 9From:Diabetes Care (Vol. 45, Issue 1) Peer-ReviewedCitation Only
- 10From:Diabetes (Vol. 54, Issue 6) Peer-Reviewed
A single course of anti-CD3 monoclonal antibody hOKT3[gamma]1(Ala-Ala) results in improvement in c-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetesDespite advances in understanding autoimmune diabetes in animal models, there has been little progress in altering the natural course of the human disease, which involves progression to insulin deficiency. Studies with...
- 11From:Diabetes (Vol. 58, Issue 5) Peer-Reviewed
Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes.OBJECTIVE--Insulin deficiency in type 1 diabetes and in rodent autoimmune diabetes models is caused by β-cell-specific killing by autoreactive T-cells. Less is known about B-cell numbers and phenotype remaining at...
- 12From:PLoS ONE (Vol. 12, Issue 6) Peer-Reviewed
Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR modelBackground/Aims Studies of human cadaveric pancreas specimens indicate that pancreas inflammation plays an important role in type 1 diabetes pathogenesis. Due to the inaccessibility of pancreas in living patients,...
- 13From:The Lancet (Vol. 363, Issue 9406) Peer-ReviewedAbstract Only
- 14From:Proceedings of the National Academy of Sciences of the United States (Vol. 97, Issue 1) Peer-Reviewed
A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: Possible role of membrane TNFAbstract Only
- 15From:Journal of Autoimmunity (Vol. 11, Issue 4) Peer-ReviewedAbstract Only
- 16From:Diabetes Care (Vol. 32, Issue 7) Peer-Reviewed
Effect of ingested interferon-[alpha] on [beta]-cell function in children with new-onset type 1 diabetesOBJECTIVE--To evaluate the safety and efficacy of ingested human recombinant interferon-[alpha] (hrIFN-[alpha] for preservation of [beta]-cell function in young patients with recent-onset type 1 diabetes. RESEARCH...
- 17From:Diabetes (Vol. 51, Issue 7) Peer-Reviewed
Pancreatic islet transplantation using the nonhuman primate (Rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion siteWe've established a nonhuman primate islet allotransplant model to address questions such as whether transplanting islets into the gut's arterial system would more safely and as effectively support long-term islet...
- 18From:Proceedings of the National Academy of Sciences of the United States (Vol. 91, Issue 8) Peer-Reviewed
Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsivenessAbstract Only
- 19From:Nature Biotechnology (Vol. 34, Issue 3) Peer-Reviewed
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primatesThe foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient (1-6). There is a critical need for biomaterials that overcome this key...
- 20From:Nature Biotechnology (Vol. 27, Issue 11) Peer-Reviewed
Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection.Analyzing specialized cells in heterogeneous tissues is crucial for understanding organ function in health and disease. Thus far, however, there has been no convenient method for studying gene expression in cells...
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