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    Academic Journals

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• Select An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes.

  1

  An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes.

  Authors:Alan G. Derr, Adediwura Arowosegbe, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Zhiru Guo, et al.From:Diabetes (Vol. 72, Issue 2) Peer-Reviewed

  Feb. 2023 Report

   Citation Only
• Select CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

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  CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

  Authors:Allan D. Dirk, David M. Harlan, Nicholas N. Armstrong, Thomas A. Davis, Yinchen Dong, Gary S. Gray, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 94, Issue 16) Peer-Reviewed

  Aug. 5, 1997249 words Article

   Abstract Only
• Select Counterpoint: clinical islet transplantation: not ready for prime time

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  Counterpoint: clinical islet transplantation: not ready for prime time

  Authors:Mahfuzul H. Khan and David M. HarlanFrom:Diabetes Care (Vol. 32, Issue 8) Peer-Reviewed

  Aug. 20094,210 words Article 1550L[beta]-Cell replacement therapy's great promise is that it can safely and effectively restore insulin-independent euglycemia to individuals with diabetes. Although difficult and expensive, modern insulin-based treatment...
• Select Reply to Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

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  Reply to Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

  Authors:Allan D. Kirk and David M. HarlanFrom:Nature Medicine (Vol. 6, Issue 2) Peer-Reviewed

  Feb. 2000259 words Brief article Author(s): Allan D. Kirk; David M. Harlan Kirk and Harlan reply Kawai and colleagues report a considerable number of thromboembolic events in monkeys after administration of a mouse monoclonal antibody against...
• Select Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors

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  Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors

  Authors:Anthony T. Craig, Oksana Gavrilova, Nancy K. Dwyer, William Jou, Stephanie Pack, Eric Liu, et al.From:Virology Journal (Vol. 6) Peer-Reviewed

  May 18, 20095,576 words Report Authors: Anthony T Craig [1,2]; Oksana Gavrilova [3]; Nancy K Dwyer [4]; William Jou [3]; Stephanie Pack [3]; Eric Liu [5]; Klaus Pechhold [5]; Michael Schmidt [6]; Victor J McAlister [1]; John A Chiorini [6]; E Joan...
• Select Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

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  Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

  Authors:Jenny Aurielle B Babon, Megan E DeNicola, David M Blodgett, Inne Crevecoeur, Thomas S Buttrick, Rene Maehr, et al.From:Nature Medicine (Vol. 23, Issue 2) Peer-Reviewed

  Feb. 2017109 words Brief article, Corre... 1180LAuthor(s): Jenny Aurielle B Babon; Megan E DeNicola; David M Blodgett; Inne Crèvecoeur; Thomas S Buttrick; René Maehr; Rita Bottino; Ali Naji; John Kaddis; Wassim Elyaman; Eddie A James; Rachana Haliyur; Marcela...
• Select Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4.sup.+ T Cells in Patients With Type 1 Diabetes

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  Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4.sup.+ T Cells in Patients With Type 1 Diabetes

  Authors:Meghan L. Marre, John W. McGinty, I-Ting Chow, Megan E. DeNicola, Noah W. Beck, Sally C. Kent, et al.From:Diabetes (Vol. 67, Issue 7) Peer-Reviewed

  July 2018 Report

   Citation Only
• Select Human islets expressing HNF1A variant have defective [beta] cell transcriptional regulatory networks

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  Human islets expressing HNF1A variant have defective [beta] cell transcriptional regulatory networks

  Authors:Rachana Haliyur, Xin Tong, May Sanyoura, Shristi Shrestha, Jill Lindner, Diane C. Saunders, et al.From:Journal of Clinical Investigation (Vol. 129, Issue 1) Peer-Reviewed

  Jan. 20194,114 words Report 1620LUsing an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained [beta] cells without insulitis and...
• Select The Noble and Often Nobel Role Played by Insulin-Focused Research in Modern Medicine.

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  The Noble and Often Nobel Role Played by Insulin-Focused Research in Modern Medicine.

  Authors:Victor S. Harrison, Mahfuzul H. Khan, Christine E. Chamberlain, and David M. HarlanFrom:Diabetes Care (Vol. 45, Issue 1) Peer-Reviewed

  Jan. 2022 Report

   Citation Only
• Select A single course of anti-CD3 monoclonal antibody hOKT3[gamma]1(Ala-Ala) results in improvement in c-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

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  A single course of anti-CD3 monoclonal antibody hOKT3[gamma]1(Ala-Ala) results in improvement in c-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

  Authors:Kevan C. Herold, Stephen E. Gitelman, Umesh Masharani, William Hagopian, Brygida Bisikirska, David Donaldson, et al.From:Diabetes (Vol. 54, Issue 6) Peer-Reviewed

  June 20055,532 words Article Despite advances in understanding autoimmune diabetes in animal models, there has been little progress in altering the natural course of the human disease, which involves progression to insulin deficiency. Studies with...
• Select Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes.

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  Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes.

  Authors:Klaus Pechhold, Xiaolong Zhu, Victor S. Harrison, Janet Lee, Sagarika Chakrabarty, Kerstin Koczwara, et al.From:Diabetes (Vol. 58, Issue 5) Peer-Reviewed

  May 20095,762 words Report 1700LOBJECTIVE--Insulin deficiency in type 1 diabetes and in rodent autoimmune diabetes models is caused by β-cell-specific killing by autoreactive T-cells. Less is known about B-cell numbers and phenotype remaining at...
• Select Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model

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  Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model

  Authors:Frederick R. Roberts, Clinton Hupple, Elaine Norowski, Nicole C. Walsh, Natalia Przewozniak, Ken-Edwin Aryee, et al.From:PLoS ONE (Vol. 12, Issue 6) Peer-Reviewed

  June 12, 20177,057 words Report 1570LBackground/Aims Studies of human cadaveric pancreas specimens indicate that pancreas inflammation plays an important role in type 1 diabetes pathogenesis. Due to the inaccessibility of pancreas in living patients,...
• Select Insulinomas and expression of an insulin splice variant

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  Insulinomas and expression of an insulin splice variant

  Authors:Alexandra H Minn, Mark Kayton, Dominique Lorang, Steven C Hoffmann, David M Harlan, Steven K Libutti, et al.From:The Lancet (Vol. 363, Issue 9406) Peer-Reviewed

  Jan. 31, 2004273 words Article

   Abstract Only
• Select A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: Possible role of membrane TNF

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  A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: Possible role of membrane TNF

  Authors:Pedro Luis Herrera, David M. Harlan, and Pierre VassalliFrom:Proceedings of the National Academy of Sciences of the United States (Vol. 97, Issue 1) Peer-Reviewed

  Jan. 4, 2000209 words Article

   Abstract Only
• Select Low Dose Poly I:C Prevents Diabetes in the Diabetes Prone BB Rat

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  Low Dose Poly I:C Prevents Diabetes in the Diabetes Prone BB Rat

  Authors:Douglas O. Sobel, Deepshika Goyal, Behrouz Ahvazi, Ji-Won Yoon, Young Hwa Chung, Adam Bagg, et al.From:Journal of Autoimmunity (Vol. 11, Issue 4) Peer-Reviewed

  Aug. 1998444 words Article

   Abstract Only
• Select Effect of ingested interferon-[alpha] on [beta]-cell function in children with new-onset type 1 diabetes

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  Effect of ingested interferon-[alpha] on [beta]-cell function in children with new-onset type 1 diabetes

  Authors:Kristina I. Rother, Rebecca J. Brown, Miriam M. Morales, Elizabeth Wright, Zhigang Duan, Carol Campbell, et al.From:Diabetes Care (Vol. 32, Issue 7) Peer-Reviewed

  July 20094,118 words Article 1490LOBJECTIVE--To evaluate the safety and efficacy of ingested human recombinant interferon-[alpha] (hrIFN-[alpha] for preservation of [beta]-cell function in young patients with recent-onset type 1 diabetes. RESEARCH...
• Select Pancreatic islet transplantation using the nonhuman primate (Rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site

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  Pancreatic islet transplantation using the nonhuman primate (Rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site

  Authors:Boaz Hirshberg, Sean Montgomery, Michael G. Wysoki, He Xu, Doug Tadaki, Janet Lee, et al.From:Diabetes (Vol. 51, Issue 7) Peer-Reviewed

  July 20024,774 words Article We've established a nonhuman primate islet allotransplant model to address questions such as whether transplanting islets into the gut's arterial system would more safely and as effectively support long-term islet...
• Select Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness

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  Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness

  Authors:David M. Harlan, Hans Hengartner, Mark L. Huang, Yuan-Hsu Kang, Ryo Abe, Randall W. Moreadith, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 91, Issue 8) Peer-Reviewed

  Apr. 12, 199445 words Article

   Abstract Only
• Select Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

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  Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

  Authors:Arturo J. Vegas, Omid Veiseh, Joshua C. Doloff, Minglin Ma, Hok Hei Tam, Kaitlin Bratlie, et al.From:Nature Biotechnology (Vol. 34, Issue 3) Peer-Reviewed

  Mar. 201611,968 words Report 1450LThe foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient (1-6). There is a critical need for biomaterials that overcome this key...
• Select Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection.

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  Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection.

  Authors:Susanne Pechhold, Melissa Stouffer, Gregory Walker, Ralph Martel, Bruce Seligmann, Yan Hang, et al.From:Nature Biotechnology (Vol. 27, Issue 11) Peer-Reviewed

  Nov. 1, 20094,223 words Brief article 1520LAnalyzing specialized cells in heterogeneous tissues is crucial for understanding organ function in health and disease. Thus far, however, there has been no convenient method for studying gene expression in cells...