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• Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men

  Authors:James Gibney, Troels Wolthers, Gudmundur Johannsson, A. Margot Umpleby, and Ken K.Y. HoFrom:American Journal of Physiology (Consolidated) (Vol. 289, Issue 2) Peer-Reviewed

  Aug. 2005244 words Author abstract

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• Acute hyperinsulinemia decreases the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in NIDDM

  Authors:Michael H. Cummings, Gerald F. Watts, A. Margot Umpleby, Thomas R. Hennessy, Joanne M. Kelly, Nicola C. Jackson, et al.From:Diabetes (Vol. 44, Issue 9) Peer-Reviewed

  Sept. 19955,568 words Article In a randomized crossover study, we measured the hepatic secretion rate of very-low-density lipoprotein (VLDL) apolipoprotein B-100 (apoB) in seven patients with well-controlled non-insulin-dependent diabetes mellitus...

• Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease

  Authors:Christopher J.A. Pugh, Victoria S. Sprung, Graham J. Kemp, Paul Richardson, Fariba Shojaee-Moradie, A. Margot Umpleby, et al.From:American Journal of Physiology (Consolidated) (Vol. 307, Issue 5) Peer-Reviewed

  Nov. 2014332 words Author abstract, Rep...

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• Effects of recombinant human IGF-I/IGF-binding protein-3 complex on glucose and glycerol metabolism in type 1 diabetes.

  Authors:Tero Saukkonen, Fariba Shojaee-Moradie, Rachel M. Williams, Rakesh Amin, Kevin C. Yuen, Angie Watts, et al.From:Diabetes (Vol. 55, Issue 8) Peer-Reviewed

  Aug. 20064,071 words Article 1760LRecombinant human IGF-I (rhIGF-I) complexed with its natural binding protein IGF-binding protein (IGFBP)-3 (rhIGF-I/IGFBP-3) is a novel formulation that has been shown to improve insulin sensitivity in type 1 diabetes,...

• Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1[beta] and -1[alpha] mutations

  Authors:Anna Brackenridge, Ewan R. Pearson, Fariba Shojaee-Moradie, Andrew T. Hattersley, David Russell-Jones, and A. Margot UmplebyFrom:Diabetes (Vol. 55, Issue 2) Peer-Reviewed

  Feb. 20065,183 words Article Heterozygous mutations in the transcription factors hepatocyte nuclear factor (HNF)-1[alpha] and -1[beta] result in MODY (maturity-onset diabetes of the young). Despite structural similarity between HNF-1[alpha] and...

• A family with severe insulin resistance and diabetes due to a mutation in AKT2

  Authors:Stella George, Justin J. Rochford, Christian Wolfrum, Sarah L. Gray, Sven Schinner, Jenny C. Wilson, et al.From:Science (Vol. 304, Issue 5675) Peer-Reviewed

  May 28, 20041,922 words Article 1550LInherited defects in signaling pathways downstream of the insulin receptor have long been suggested to contribute to human type 2 diabetes mellitus. Here we describe a mutation in the gene encoding the protein kinase...

• Insulin detemir reduces weight gain as a result of reduced food intake in patients with type 1 diabetes

  Authors:Sunil Zachariah, Ben Sheldon, Fariba Shojaee-Moradie, Nicola C. Jackson, Katharine Backhouse, Sigurd Johnsen, et al.From:Diabetes Care (Vol. 34, Issue 7) Peer-Reviewed

  July 20114,075 words Report 1450LOBJECTIVE--Insulin detemir lacks the usual propensity for insulin to cause weight gain. We investigated whether this effect was a result of reduced energy intake and/or increased energy expenditure. RESEARCH DESIGN...

• Prandial hypertriglyceridemia in metabolic syndrome is due to an overproduction of both chylomicron and VLDL triacylglycerol

  Authors:Fariba Shojaee-Moradie, Yuying Ma, Shaoying Lou, Roman Hovorka, and A. Margot UmplebyFrom:Diabetes (Vol. 62, Issue 12) Peer-Reviewed

  Dec. 20135,228 words Report 1470LThe aim was to determine whether fed VLDL and chylomicron (CM) triacylglycerol (TAG) production rates are elevated in metabolic syndrome (MetS). Eight men with MetS (BMI 29.7 [+ or -] 1.1) and eight lean age-matched...

• Prandial Hypertriglyceridemia in Metabolic Syndrome Is Due to an Overproduction of Both Chylomicron and VLDL Triacylglycerol

  Authors:Fariba Shojaee-Moradie, Yuying Ma, Shaoying Lou, Roman Hovorka, and A. Margot UmplebyFrom:Diabetes (Vol. 63, Issue 2) Peer-Reviewed

  Feb. 201456 words Brief article, Corre... 1050LPrandial Hypertriglyceridemia in Metabolic Syndrome Is Due to an Overproduction of Both Chylomicron and VLDL Triacylglycerol. Diabetes 2013;62:4063-4069 DOI: 10.2337/db14-er02a In the Acknowledgments of the...

• A novel method for measuring intestinal and hepatic triacylglycerol kinetics

  Authors:Feifei Sun, Mike Stolinski, Fariba Shojaee-Moradie, Shaoying Lou, Yuying Ma, Roman Hovorka, et al.From:American Journal of Physiology (Consolidated) (Vol. 305, Issue 4) Peer-Reviewed

  Oct. 2013260 words Author abstract, Rep...

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• Metabolic Effects of an SGLT2 Inhibitor (Dapagliflozin) During a Period of Acute Insulin Withdrawal and Development of Ketoacidosis in People With Type 1 Diabetes.

  Authors:Roselle A. Herring, Fariba Shojaee-Moradie, Robert Garesse, Mary Stevenage, Nicola Jackson, Barbara A. Fielding, et al.From:Diabetes Care (Vol. 43, Issue 9) Peer-Reviewed

  Sept. 2020 Report

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• The SGLT2 Inhibitor Dapagliflozin Increases the Oxidation of Ingested Fatty Acids to Ketones in Type 2 Diabetes.

  Authors:Roselle Herring, Fariba Shojaee-Moradie, Mary Stevenage, Iain Parsons, Nicola Jackson, Jeewaka Mendis, et al.From:Diabetes Care (Vol. 45, Issue 6) Peer-Reviewed

  June 2022 Report

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• Exercise training improves cutaneous microvascular function in nonalcoholic fatty liver disease

  Authors:Christopher J.A. Pugh, Daniel J. Cuthbertson, Victoria S. Sprung, Graham J. Kemp, Paul Richardson, A. Margot Umpleby, et al.From:American Journal of Physiology (Consolidated) (Vol. 305, Issue 1) Peer-Reviewed

  July 2013276 words Author abstract, Rep...

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• Effect of IGF-I therapy on VLDL apolipoprotein B100 metabolism in type 1 diabetes mellitus

  Authors:Emanuel R. Christ, Paul V. Carroll, Elaine Albany, A. Margot Umpleby, Peter J. Lumb, Anthony S. Wierzbicki, et al.From:American Journal of Physiology (Consolidated) (Vol. 282, Issue 5) Peer-Reviewed

  May 2002241 words Abstract

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• Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT

  Authors:Roman Hovorka, Fariba Shojaee-Moradie, Paul V. Carroll, Ludovich Chassin, Ian J. Gowrie, Nicola C. Jackson, et al.From:American Journal of Physiology (Consolidated) (Vol. 282, Issue 5) Peer-Reviewed

  May 2002378 words Abstract

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• Combined growth hormone/insulin-like growth factor I in addition to glutamine-supplemented TPN results in net protein anabolism in critical illness

  Authors:Paul V. Carroll, Nicola C. Jackson, David L. Russell-Jones, David F. Treacher, Peter H. Sonksen, and A. Margot UmplebyFrom:American Journal of Physiology (Consolidated) (Vol. 286, Issue 1) Peer-Reviewed

  Jan. 2004303 words Author abstract

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• IGF-I Treatment in Adults With Type 1 Diabetes

  Authors:Paul V. Carroll, Emanuel R. Christ, A. Margot Umpleby, Ian Gowrie, Nicola Jackson, Susan B. Bowes, et al.From:Diabetes (Vol. 49, Issue 5) Peer-Reviewed

  May 20006,596 words Article Effects on Glucose and Protein Metabolism in the Fasting State and During a Hyperinsulinemic-Euglycemic Amino Acid Clamp Type 1 diabetes is associated with abnormalities of the growth hormone (GH)--IGF-I axis. Such...

• Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-[gamma]. (Metabolism and Signal Transduction)

  Authors:David B. Savage, Garry D. Tan, Carlo L. Acerini, Susan A. Jebb, Maura Agostini, Mark Gurnell, et al.From:Diabetes (Vol. 52, Issue 4) Peer-Reviewed

  Apr. 20035,839 words Article We previously reported a syndrome of severe hyperinsulinemia and early-onset hypertension in three patients with dominant-negative mutations in the nuclear hormone receptor peroxisome proliferator-activated receptor...

• A surrogate measure of whole body leucine transport across the cell membrane

  Authors:Roman Hovorka, Paul V. Carroll, Ian J. Gowrie, Nicola C. Jackson, David L. Russell-Jones, and A. Margot UmplebyFrom:American Journal of Physiology (Consolidated) (Vol. 276, Issue 3) Peer-Reviewed

  Mar. 199973 words Article

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• The fat mass and obesity-associated (FTO) gene allele rs9939609 and glucose tolerance, hepatic and total insulin sensitivity, in adults with obesity.

  Authors:Ann Kristin Hjelle de Soysa, Mette Langaas, Anida Jakic, Fariba Shojaee-Moradie, A. Margot Umpleby, Valdemar Grill, et al.From:PLoS ONE (Vol. 16, Issue 3) Peer-Reviewed

  Mar. 8, 20218,349 words Report 1480LThe objective of the study was to assess associations of the rs9939609 FTO allele to glucose tolerance, hepatic and total insulin sensitivity (IS) in individuals with obesity. From a low-dose hyperinsulinemic euglycemic...