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From:PLoS ONE (Vol. 16, Issue 2) Peer-ReviewedRecurrent exertional rhabdomyolysis (RER) is a chronic muscle disorder of unknown etiology in racehorses. A potential role of intramuscular calcium (Ca.sup.2+) dysregulation in RER has led to the use of dantrolene to...
From:PLoS ONE (Vol. 14, Issue 11) Peer-ReviewedNemaline myopathy (NEM) is a congenital neuromuscular disorder primarily caused by nebulin gene (NEB) mutations. NEM is characterized by muscle weakness for which currently no treatments exist. In NEM patients a...
From:American Journal of Physiology (Consolidated) (Vol. 298, Issue 5) Peer-ReviewedAbstract Only
From:PLoS ONE (Vol. 15, Issue 12) Peer-ReviewedIn order to elucidate involvement of cyclic AMP and intracellular Ca.sup.2+,[Ca.sup.2+ ].sub.i, in the modulation of aqueous humour formation (AHF), we studied the effects of terbutaline, forskolin and 8-Br-cAMP in the...
From:PLoS ONE (Vol. 10, Issue 9) Peer-ReviewedThe process of Ca.sup.2+ release from sarcoplasmic reticulum (SR) comprises 4 phases in smooth muscle cells. Phase 1 is characterized by a large increase of the intracellular Ca.sup.2+ concentration ([Ca.sup.2+ ].sub.i)...
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