Search Results

• • 9 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

  Authors:Isaline Rowe, Marco Chiaravalli, Valeria Mannella, Valeria Ulisse, Giacomo Quilici, Monika Pema, et al.From:Nature Medicine (Vol. 19, Issue 4) Peer-Reviewed

  Apr. 20135,301 words Article 1390LAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by bilateral renal cyst formation (1). Recent identification of signaling cascades deregulated in ADPKD has led to the...

• Nephrocystin-1 Forms a Complex with Polycystin-1 via a Polyproline Motif/SH3 Domain Interaction and Regulates the Apoptotic Response in Mammals

  Authors:Claas Wodarczyk, Gianfranco Distefano, Isaline Rowe, Massimiliano Gaetani, Barbara Bricoli, Mordi Muorah, et al.From:PLoS ONE (Vol. 5, Issue 9) Peer-Reviewed

  Sept. 14, 20107,484 words Article 1470LMutations in PKD1, the gene encoding for the receptor Polycystin-1 (PC-1), cause autosomal dominant polycystic kidney disease (ADPKD). The cytoplasmic C-terminus of PC-1 contains a coiled-coil domain that mediates an...

• Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca.sup.2+ Entry through Interactions with STIM1

  Authors:Owen M. Woodward, Yun Li, Shengqiang Yu, Patrick Greenwell, Claas Wodarczyk, Alessandra Boletta, et al.From:PLoS ONE (Vol. 5, Issue 8) Peer-Reviewed

  Aug. 23, 20107,346 words Article 1460LAutosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder resulting in large kidney cysts and eventual kidney failure. Mutations in either the PKD1 or PKD2/TRPP2 genes and their respective protein...

• A Novel Mouse Model Reveals that Polycystin-1 Deficiency in Ependyma and Choroid Plexus Results in Dysfunctional Cilia and Hydrocephalus

  Authors:Claas Wodarczyk, Isaline Rowe, Marco Chiaravalli, Monika Pema, Feng Qian, and Alessandra BolettaFrom:PLoS ONE (Vol. 4, Issue 9) Peer-Reviewed

  Sept. 23, 20099,844 words Article 1530LPolycystin-1 (PC-1), the product of the PKD1 gene, mutated in the majority of cases of Autosomal Dominant Polycystic Kidney Disease (ADPKD), is a very large (~520 kDa) plasma membrane receptor localized in several...

• PKD1 induces p21(sup)waf1 and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

  Authors:Anil Kumar Bhunia, Klaus Piontek, Alessandra Boletta, Lijuan Liu, Feng Qian, Pei-Ning Xu, et al.From:Cell (Vol. 109, Issue 2) Peer-Reviewed

  Apr. 19, 200250 words Article

   Abstract Only

• Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations

  Authors:Feng Qian, Alessandra Boletta, Anil K. Bhunia, Hangxue Xu, Lijuan Liu, Ali K. Ahrabi, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 99, Issue 26) Peer-Reviewed

  Dec. 24, 2002107 words Abstract

   Abstract Only

• Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

  Authors:Kazushige Hanaoka, Feng Qian, Alessandra Boletta, Anil K. Bhunia, Klaus Piontek, Leonidas Tsiokas, et al.From:Nature (Vol. 408, Issue 6815) Peer-Reviewed

  Dec. 21, 20004,263 words Article 1530LAuthor(s): Kazushige Hanaoka [1, 2]; Feng Qian [2, 3]; Alessandra Boletta [2, 3]; Anil K. Bhunia [3]; Klaus Piontek [3]; Leonidas Tsiokas [4]; Vikas P. Sukhatme [5]; William B. Guggino (corresponding author) [1];...

• Emerging evidence of a link between the polycystins and the mTOR pathways

  Author:Alessandra BolettaFrom:PathoGenetics (Vol. 2) Peer-Reviewed

  Oct. 28, 200912,786 words Report Authors: Alessandra Boletta (corresponding author) [1] ADPKD: genetics and proposed mechanisms of cystogenesis Autosomal dominant polycystic kidney disease (ADPKD) is a frequent genetic disease, affecting between...

• Casein kinase 1[epsilon] and 1[alpha] as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8

  Authors:Katy Billot, Charlene Coquil, Benoit Villiers, Beatrice Josselin-Foll, Nathalie Desban, Claire Delehouze, et al.From:American Journal of Physiology (Consolidated) (Vol. 315, Issue 1) Peer-Reviewed

  July 2018170 words Author abstract, Rep...

   Abstract Only