Search Results

• • 13 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity.

  Authors:Charles W. Tran, Matthew J. Gold, Carlos Garcia-Batres, Kelly Tai, Alisha R. Elford, Megan E. Himmel, et al.From:PLoS ONE (Vol. 15, Issue 12) Peer-Reviewed

  Dec. 31, 20207,396 words Report 1560LDendritic cells are sentinels of the immune system and represent a key cell in the activation of the adaptive immune response. Hypoxia-inducible factor 1 alpha (HIF-1[alpha])-a crucial oxygen sensor stabilized during...

• TCR affinity and negative regulation limit autoimmunity

  Authors:Matthew A Gronski, Jonathan M Boulter, Demetrius Moskophidis, Linh T Nguyen, Kaisa Holmberg, Alisha R Elford, et al.From:Nature Medicine (Vol. 10, Issue 11) Peer-Reviewed

  Nov. 20044,864 words Article Author(s): Matthew A Gronski [1]; Jonathan M Boulter [2]; Demetrius Moskophidis [3]; Linh T Nguyen [1]; Kaisa Holmberg [4]; Alisha R Elford [1]; Elissa K Deenick [1]; Hee O Kim [4]; Josef M Penninger [5]; Bernhard...

• Peptide-Pulsed Dendritic Cells Have Superior Ability to Induce Immune-Mediated Tissue Destruction Compared to Peptide with Adjuvant

  Authors:Dilan Dissanayake, Kiichi Murakami, Michael D. Tran, Alisha R. Elford, Douglas G. Millar, and Pamela S. OhashiFrom:PLoS ONE (Vol. 9, Issue 3) Peer-Reviewed

  Mar. 19, 20147,958 words Article 1640LAuthor(s): Dilan Dissanayake 1,2, Kiichi Murakami 1, Michael D. Tran 1, Alisha R. Elford 1, Douglas G. Millar 1, Pamela S. Ohashi 1,2,* Introduction Numerous studies have described the existence of tumor-specific...

• Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes

  Authors:Nobuyuki Ono, Kiichi Murakami, Olivia Chan, Hakan Hall, Alisha R. Elford, Patty Yen, et al.From:PLoS ONE (Vol. 12, Issue 3) Peer-Reviewed

  Mar. 3, 20177,789 words Report 1590LAlthough the role of T cells in autoimmunity has been explored for many years, the mechanisms leading to the initial priming of an autoimmune T cell response remain enigmatic. The 'hit and run' model suggests that...

• CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity

  Authors:Thomas Calzascia, Marc Pellegrini, Albert Lin, Kristine M. Garza, Alisha R. Elford, Arda Shahinian, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 105, Issue 8) Peer-Reviewed

  Feb. 26, 2008227 words Author abstract, Rep...

   Abstract Only

• Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

  Authors:Douglas G Millar, Kristine M Garza, Bernhard Odermatt, Alisha R Elford, Nobuyuki Ono, Zihai Li, et al.From:Nature Medicine (Vol. 9, Issue 12) Peer-Reviewed

  Dec. 20036,744 words Article Pathogens or pathogen-associated molecular patterns can signal to cells of the innate immune system and trigger effective adaptive immunity. However, relatively little is known about how the innate immune system detects...

• Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

  Authors:Marc Pellegrini, Thomas Calzascia, Alisha R. Elford, Arda Shahinian, Amy E. Lin, Dilan Dissanayake, et al.From:Nature Medicine (Vol. 15, Issue 5) Peer-Reviewed

  May 20096,813 words Report 1480LIdentifying key factors that enhance immune responses is crucial for manipulating immunity to tumors. We show that after a vaccine-induced immune response, adjuvant interleukin-7 (IL-7) improves antitumor responses and...

• TNF-[alpha] is critical for antitumor but not antiviral T cell immunity in mice

  Authors:Thomas Calzascia, Marc Pellegrini, Hakan Hall, Laurent Sabbagh, Nobuyuki Ono, Alisha R. Elford, et al.From:Journal of Clinical Investigation (Vol. 117, Issue 12) Peer-Reviewed

  Dec. 20079,067 words Article 1460LTNF-[alpha] antagonists are widely used in the treatment of inflammatory and autoimmune diseases, but their use is associated with reactivation of latent infections. This highlights the importance of TNF-[alpha] in...

• Different Toll-Like Receptor Stimuli Have a Profound Impact on Cytokines Required to Break Tolerance and Induce Autoimmunity

  Authors:Albert C. C. Lin, Dilan Dissanayake, Salim Dhanji, Alisha R. Elford, and Pamela S. OhashiFrom:PLoS ONE (Vol. 6, Issue 9) Peer-Reviewed

  Sept. 12, 20118,628 words Article 1610LAlthough toll-like receptor (TLR) signals are critical for promoting antigen presenting cell maturation, it remains unclear how stimulation via different TLRs influence dendritic cell (DC) function and the subsequent...

• Nuclear factor-[kappa]B1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells

  Authors:Dilan Dissanayake, Hakan Hall, Nancy Berg-Brown, Alisha R. Elford, Sara R. Hamilton, Kiichi Murakami, et al.From:Nature Medicine (Vol. 17, Issue 12) Peer-Reviewed

  Dec. 20114,579 words Article 1400LMature dendritic cells (DCs) are crucial for the induction of adaptive immune responses and perturbed DC homeostasis can result in autoimmune disease. Either uncontrolled expansion (1) or enhanced survival (2,3) of DCs...

• Choline acetyltransferase-expressing T cells are required to control chronic viral infection

  Authors:Maureen A. Cox, Gordon S. Duncan, Gloria H.Y. Lin, Benjamin E. Steinberg, Lisa X. Yu, Dirk Brenner, et al.From:Science (Vol. 363, Issue 6427) Peer-Reviewed

  Feb. 8, 20194,030 words Article 1490L

   Abstract Only

• Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting [CD8.sup.+] T-cell immunity

  Authors:Philipp A. Lang, Karl S. Lang, Haifeng C. Xu, Melanie Grusdat, Ian A. Parish, Mike Recher, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 109, Issue 4) Peer-Reviewed

  Jan. 24, 2012 Author abstract, Rep...

   Citation Only

• Targeting of pancreatic glia in type 1 diabetes

  Authors:Hubert Tsui, Yin Chan, Lan Tang, Shawn Winer, Roy K. Cheung, Geoffrey Paltser, et al.From:Diabetes (Vol. 57, Issue 4) Peer-Reviewed

  Apr. 20086,094 words Clinical report 1450LOBJECTIVE--Type 1 diabetes reflects autoimmune destruction of [beta]-cells and peri-islet Schwann ceils (pSCs), but the mechanisms of pSC death and the T-cell epitopes involved remain unclear. RESEARCH DESIGN AND...