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From:PLoS ONE (Vol. 11, Issue 10) Peer-Reviewed
Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles
Background Although reduced glutathione (rGSH) is decreased in obese mice and humans, block of GSH synthesis by buthionine sulfoximine (BSO) results in a lean, insulin-sensitive phenotype. Data is lacking about the... -
From:PLoS ONE (Vol. 7, Issue 9) Peer-ReviewedContext Plasma total cysteine (tCys) independently relates to fat mass in adults. Dietary cyst(e)ine promotes adiposity and decreases glucose tolerance in some rodent models, but alleviates insulin resistance in...
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From:PLoS ONE (Vol. 12, Issue 5) Peer-ReviewedObjective Although adipose tissue hydrogen peroxide (H.sub.2 O.sub.2) and its metabolizing enzymes have been linked to obesity and insulin resistance in animal studies, this relation remains to be evaluated in...