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From:PLoS ONE (Vol. 8, Issue 3) Peer-ReviewedLinks between carbohydrate metabolism and virulence in Streptococcus pneumoniae have been recurrently established. To investigate these links further we developed a chemically defined medium (CDM) and standardized...
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From:PLoS ONE (Vol. 10, Issue 3) Peer-ReviewedThe human pathogen Streptococcus pneumoniae is a strictly fermentative organism that relies on glycolytic metabolism to obtain energy. In the human nasopharynx S. pneumoniae encounters glycoconjugates composed of a...
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From:Proceedings of the National Academy of Sciences of the United States (Vol. 103, Issue 25) Peer-ReviewedAbstract Only
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From:PLoS ONE (Vol. 8, Issue 3) Peer-ReviewedThe ability to successfully adapt to changing host conditions is crucial for full virulence of bacterial pathogens. Staphylococcus aureus has to cope with fluctuating oxygen concentrations during the course of...
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From:PLoS ONE (Vol. 6, Issue 10) Peer-ReviewedIn Gram-positive bacteria, the transcriptional regulator CcpA is at the core of catabolite control mechanisms. In the human pathogen Streptococcus pneumoniae, links between CcpA and virulence have been established, but...
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From:Science (Vol. 302, Issue 5653) Peer-ReviewedCalorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NA[D.sup.+]-dependent deacetylase. We report that CR reduces nuclear NA[D.sup.+]...
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From:BioMed Research International (Vol. 2017) Peer-ReviewedNowadays, the society is facing a large health problem with the rising of new diseases, including cancer, heart diseases, diabetes, neurodegenerative diseases, and obesity. Thus, it is important to invest in substances...