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From:PLoS ONE (Vol. 16, Issue 1) Peer-ReviewedThe traditional approach to biomarker discovery for any pathology has been through hypothesis-based research one candidate at a time. The objective of this study was to develop an agnostic approach for the simultaneous...
From:Alzheimer's Research & Therapy (Vol. 12, Issue 1) Peer-ReviewedBackground Plasma neurofilament light (NFL) and total Tau (t-Tau) proteins are candidate biomarkers for early stages of Alzheimer's disease (AD). The impact of biological factors on their plasma concentrations in...
From:Alzheimer's Research & Therapy (Vol. 12, Issue 1) Peer-Reviewed[beta]-Secretase1 (BACE1) protein concentrations and rates of enzyme activity, analyzed in human bodily fluids, are promising candidate biological markers for guidance in clinical trials investigating BACE1 inhibitors...
From:Frontiers in PharmacologyPeer-ReviewedAuthor(s): Harald Hampel, Edward J. Goetzl, Dimitrios Kapogiannis, Simone Lista, Andrea Vergallo Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped...
From:Frontiers in NeurosciencePeer-ReviewedAuthor(s): Yuhai Zhao, Vivian Jaber, Peter N. Alexandrov, Andrea Vergallo, Simone Lista, Harald Hampel, Walter J. Lukiw Alzheimer's disease (AD) is a multifactorial, age-related neurological disease characterized by...
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