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    Academic Journals

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• Genetic-epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity

  Authors:Mihaela Stefan, Chengguo Wei, Angela Lombardi, Cheuk Wun Li, Erlinda S. Concepcion, William B. Inabnet, III, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 111, Issue 34) Peer-Reviewed

  Aug. 26, 2014213 words Author abstract, Rep...

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• Metabolic Flexibility of Mitochondria Plays a Key Role in Balancing Glucose and Fatty Acid Metabolism in the Diabetic Heart.

  Authors:Jessica Gambardella, Angela Lombardi, and Gaetano SantulliFrom:Diabetes (Vol. 69, Issue 10) Peer-Reviewed

  Oct. 2020 Article

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• Miniaturized metalloproteins: Application to iron-sulfur proteins

  Authors:Angela Lombardi, Daniela Marasco, Ornella Maglio, Luigi Di Costanzo, Flavia Nastri, and Vincenzo PavoneFrom:Proceedings of the National Academy of Sciences of the United States (Vol. 97, Issue 22) Peer-Reviewed

  Oct. 24, 2000195 words Article

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• Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation.

  Authors:Luigi Mele, Marcella la Noce, Francesca Paino, Tarik Regad, Sarah Wagner, Davide Liccardo, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 38, Issue 1) Peer-Reviewed

  Apr. 12, 20196,824 words Article 1430LBackground Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to...

• Preorganization of molecular binding sites in designed diiron proteins

  Authors:Ornella Maglio, Flavia Nastri, Vincenzo Pavone, Angela Lombardi, and William F. DeGradoFrom:Proceedings of the National Academy of Sciences of the United States (Vol. 100, Issue 7) Peer-Reviewed

  Apr. 1, 2003232 words Brief article

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• De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles

  Authors:Shao-Qing Zhang, Marco Chino, Lijun Liu, Xiaozhen Hu, Youzhi Tang, William F. DeGrado, et al.From:Journal of the American Chemical Society (Vol. 140, Issue 4) Peer-Reviewed

  Jan. 31, 201879 words Report

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• HDAC2 depletion promotes osteosarcoma's stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

  Authors:Marcella La Noce, Francesca Paino, Luigi Mele, Gianpaolo Papaccio, Tarik Regad, Angela Lombardi, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 37, Issue 1) Peer-Reviewed

  Dec. 3, 201813,916 words Report 1490LBackground Cancer stem cells (CSCs) play a key role in cancer initiation, progression and chemoresistance. Epigenetic alterations have been identified as prominent factors that contribute to the CSCs phenotype. Here,...

• Toward the de novo design of a catalytically active helix bundle: A substrate-accessible carboxylate-bridged dinuclear metal center

  Authors:Luigi Di Costanzo, William F. DeGrado, Herschel Wade, Angela Lombardi, Silvano Geremia, Lucio Randaccio, et al.From:Journal of the American Chemical Society (Vol. 123, Issue 51) Peer-Reviewed

  Dec. 26, 200139 words Article

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• Fluorescent peptide dH3w: A sensor for environmental monitoring of mercury (II)

  Authors:Marialuisa Siepi, Rosario Oliva, Luigi Petraccone, Pompea Del Vecchio, Ezio Ricca, Rachele Isticato, et al.From:PLoS ONE (Vol. 13, Issue 10) Peer-Reviewed

  Oct. 10, 20186,417 words Report 1570LHeavy metals are hazardous environmental contaminants, often highly toxic even at extremely low concentrations. Monitoring their presence in environmental samples is an important but complex task that has attracted the...

• Retrostructural analysis of metalloproteins: Application to the design of a minimal model for diiron proteins

  Authors:Angela Lombardi, Christopher M. Summa, Silvano Geremia, Lucio Randaccio, Vincenzo Pavone, and William F. DeGradoFrom:Proceedings of the National Academy of Sciences of the United States (Vol. 97, Issue 12) Peer-Reviewed

  June 6, 2000259 words Article

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• Allosteric cooperation in a de novo-designed two-domain protein

  Authors:Fabio Pirro, Nathan Schmidt, James Lincoff, Zachary X. Widel, Nicholas F. Polizzi, Lijun Liu, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 117, Issue 52) Peer-Reviewed

  Dec. 29, 20208,152 words Report 1390L

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• Peptide-based heme-protein models

  Authors:Angela Lombardi, Flavia Nastri, and Vincenzo PavoneFrom:Chemical Reviews (Vol. 101, Issue 10) Peer-Reviewed

  Oct. 200134 words Article

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• A novel rigid Beta-turn molecular scaffold

  Authors:Angela Lombardi, Gabriella D'Auria, Ornella Maglio, Flavia Nastri, Laura Quartara, Carlo Pedone, et al.From:Journal of the American Chemical Society (Vol. 120, Issue 24) Peer-Reviewed

  June 24, 199870 words Article

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• DTNQ-Pro, a mimetic dipeptide, sensitizes human colon cancer cells to 5-fluorouracil treatment

  Authors:Isabel Gomez-Monterrey, Pietro Campiglia, Ilaria Scognamiglio, Daniela Vanacore, Alessandra Dicitore, Angela Lombardi, et al.From:Journal of Amino AcidsPeer-Reviewed

  Annual 20134,141 words Report 1470LThe resistance of growing human colon cancer cells to chemotherapy agents has been correlated to endogenous overexpression of stress proteins including the family of heat shock proteins (HSPs). Previously, we have...

• Age-related impairment in insulin release: the essential role of [[beta].sub.2]-adrenergic receptor

  Authors:Gaetano Santulli, Angela Lombardi, Daniela Sorriento, Antonio Anastasio, Carmine Del Giudice, Pietro Formisano, et al.From:Diabetes (Vol. 61, Issue 3) Peer-Reviewed

  Mar. 20125,589 words Report 1500LIn this study, we investigated the significance of [[beta].sub.2]-adrenergic receptor ([[beta].sub.2]AR) in age-related impaired insulin secretion and glucose homeostasis. We characterized the metabolic phenotype of...

• Engineering Metalloprotein Functions in Designed and Native Scaffolds.

  Authors:Flavia Nastri, Daniele D'Alonzo, Linda Leone, Gerardo Zambrano, Vincenzo Pavone, and Angela LombardiFrom:Trends in Biochemical Sciences (Vol. 44, Issue 12) Peer-Reviewed

  Dec. 2019283 words Report, Brief articl...

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• De novo design and structural characterization of proteins and metalloproteins

  Authors:William F. DeGrado, Christopher M. Summa, Vincenzo Pavone, Flavia Nastri, and Angela LombardiFrom:Annual Review of Biochemistry (Vol. 68) Peer-Reviewed

  Annual 199931 words Article

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• Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography

  Authors:Silvano Geremia, Flavia Nastri, Luigi Di Costanzo, William P. DeGrado, Lucio Randaccio, Donald E. Engel, et al.From:Journal of the American Chemical Society (Vol. 127, Issue 49) Peer-Reviewed

  Dec. 14, 200572 words Article

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• Design of a synthetic receptor for the calmodulin-binding domain of calcineurin

  Authors:Angela Lombardi, James W. Bryson, Giovanna Ghirlanda, and William F. DeGradoFrom:Journal of the American Chemical Society (Vol. 119, Issue 50) Peer-Reviewed

  Dec. 17, 199755 words Article

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• Short-term diet and moderate exercise in young overweight men modulate cardiocyte and hepatocarcinoma survival by oxidative stress

  Authors:Marcellino Monda, Giovanni Messina, Ilaria Scognamiglio, Angela Lombardi, Giuseppe A. Martin, Pasquale Sperlongano, et al.From:Oxidative Medicine and Cellular Longevity (Vol. 2014) Peer-Reviewed

  Annual 20143,884 words Report 1470LThe present study was designed to evaluate the effects of diet lifestyle on extending lifespan and reducing liver cancer risk. Young overweight men (n = 20), without metabolic syndrome, were placed in a 3-week...