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From:Proceedings of the National Academy of Sciences of the United States (Vol. 103, Issue 12) Peer-ReviewedAbstract Only
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From:PLoS ONE (Vol. 6, Issue 4) Peer-ReviewedBackground Transgenic (TG) mice with overexpression of an arg120gly (R120G) missense mutation in HSPB5 display desmin-related cardiomyopathy, which is characterized by formation of aggresomes. It is also known that...
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From:Proceedings of the National Academy of Sciences of the United States (Vol. 102, Issue 38) Peer-ReviewedAbstract Only
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From:PLoS ONE (Vol. 8, Issue 4) Peer-ReviewedAuthor(s): Yu Tezuka 1, Mizuki Okada 1, Yuka Tada 1, Junji Yamauchi 2, Hideo Nishigori 1, Atsushi Sanbe 1,* Introduction Neural cell differentiation during development includes outgrowth of neurites, which later...
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From:Journal of Clinical Investigation (Vol. 121, Issue 9) Peer-ReviewedThe ubiquitinproteasome system degrades most intracellular proteins, including misfolded proteins. Proteasome functional insufficiency (PFI) has been observed in proteinopathies, such as desminrelated cardiosympathy,...
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From:Proceedings of the National Academy of Sciences of the United States (Vol. 101, Issue 27) Peer-ReviewedAbstract Only
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From:Nature (Vol. 483, Issue 7387) Peer-ReviewedSudden cardiac death exhibits diurnal variation in both acquired and hereditary forms of heart disease (1,2), but the molecular basis of this variation is unknown. A common mechanism that underlies susceptibility to...
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From:PLoS ONE (Vol. 4, Issue 4) Peer-ReviewedBackground An arg120gly (R120G) missense mutation in HSPB5 ([alpha]-[beta]-crystallin ), which belongs to the small heat shock protein (HSP) family, causes desmin-related cardiomyopathy (DRM), a muscle disease that...
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From:PLoS ONE (Vol. 9, Issue 8) Peer-ReviewedBackground Transgenic mice with transient cardiac expression of constitutively active Galpha q (G[alpha].sub.q -TG) exhibt progressive heart failure and ventricular arrhythmias after the initiating stimulus of...