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From:Nature Biotechnology (Vol. 34, Issue 4) Peer-ReviewedHundreds of genetically characterized cell lines are available for the discovery of genotype-specific cancer vulnerabilities. However, screening large numbers of compounds against large numbers of cell lines is...
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From:Journal of Clinical Investigation (Vol. 128, Issue 1) Peer-ReviewedPharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma, amplification of the oncogene MYCN is associated with...
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From:eLife (Vol. 6) Peer-ReviewedGenomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes...
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From:Journal of Clinical Investigation (Vol. 123, Issue 1) Peer-ReviewedBecause of the high risk of recurrence in high-grade serous ovarian carcinoma (HGS-OvCa), the development of outcome predictors could be valuable for patient stratification. Using the catalog of The Cancer Genome Atlas...
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From:Nature Medicine (Vol. 21, Issue 12) Peer-ReviewedThe authors identify EZH2 as a general underlying dependency of tumors with mutations in the SWI/SNF chromatin regulator complex, and they show that EZH2's pro-tumorigenic role may be dependent on non-catalytic...
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From:Nature Medicine (Vol. 21, Issue 12) Peer-ReviewedHuman cancer genome sequencing has recently revealed that genes that encode subunits of SWI/SNF chromatin remodeling complexes are frequently mutated across a wide variety of cancers, and several subunits of the complex...
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From:Nature Biotechnology (Vol. 34, Issue 5) Peer-ReviewedSystematic efforts to sequence the cancer genome have identified large numbers of mutations and copy number alterations in human cancers. However, elucidating the functional consequences of these variants, and their...