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From:PLoS ONE (Vol. 16, Issue 4) Peer-ReviewedT-cell receptor mimic (TCRm) antibodies have expanded the repertoire of antigens targetable by monoclonal antibodies, to include peptides derived from intracellular proteins that are presented by major histocompatibility...
From:PLoS ONE (Vol. 12, Issue 4) Peer-ReviewedTherapeutic monoclonal antibodies targeting cell surface or secreted antigens are among the most effective classes of novel immunotherapies. However, the majority of human proteins and established cancer biomarkers are...
From:PLoS ONE (Vol. 5, Issue 10) Peer-ReviewedBackground Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of...
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