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    Academic Journals

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• Development of human membrane transporters: drug disposition and pharmacogenetics

  Authors:Miriam G. Mooij, Anne T. Nies, Catherijne A. J. Knibbe, Elke Schaeffeler, Dick Tibboel, Matthias Schwab, et al.From:Clinical Pharmacokinetics (Vol. 55, Issue 5) Peer-Reviewed

  May 2016 Report

   Citation Only

• Evidence-based morphine dosing for postoperative neonates and infants

  Authors:Elke H. J. Krekels, Dick Tibboel, Saskia N. de Wildt, Ilse Ceelie, Albert Dahan, Monique van Dijk, et al.From:Clinical Pharmacokinetics (Vol. 53, Issue 6) Peer-Reviewed

  June 2014 Report

   Citation Only

• Midazolam pharmacokinetics in morbidly obese patients following semi-simultaneous oral and intravenous administration: a comparison with healthy volunteers

  Authors:Margreke J. E. Brill, Anne van Rongen, Aletta P. I. Houwink, Jacobus Burggraaf, Bert van Ramshorst, Rene J. Wiezer, et al.From:Clinical Pharmacokinetics (Vol. 53, Issue 10) Peer-Reviewed

  Oct. 2014 Report

   Citation Only

• Disease History and Medication Use as Risk Factors for the Clinical Manifestation of Type 1 Diabetes in Children and Young Adults: An Explorative Case Control Study

  Authors:Soulmaz Fazeli Farsani, Patrick C. Souverein, Marja M. J. van der Vorst, Aukje K. Mantel-Teeuwisse, Catherijne A. J. Knibbe, and Anthonius de BoerFrom:PLoS ONE (Vol. 9, Issue 2) Peer-Reviewed

  Feb. 3, 20144,032 words Article 1640LAuthor(s): Soulmaz Fazeli Farsani 1, Patrick C. Souverein 1, Marja M. J. van der Vorst 2, Aukje K. Mantel-Teeuwisse 1, Catherijne A. J. Knibbe 3,4, Anthonius de Boer 1,* Introduction Type 1 diabetes is a chronic...

• Pediatric microdose study of [14C]paracetamol to study drug metabolism using accelerated mass spectrometry: proof of concept

  Authors:Miriam G. Mooij, Esther van Duijn, Catherijne A. J. Knibbe, Albert D. Windhorst, N. Harry Hendrikse, Wouter H. J. Vaes, et al.From:Clinical Pharmacokinetics (Vol. 53, Issue 11) Peer-Reviewed

  Nov. 2014 Report

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• Successful Use of [14C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism

  Authors:Miriam G. Mooij, Esther van Duijn, Catherijne A. J. Knibbe, Karel Allegaert, Albert D. Windhorst, Joost van Rosmalen, et al.From:Clinical Pharmacokinetics (Vol. 56, Issue 10) Peer-Reviewed

  Oct. 2017 Article

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• Population pharmacokinetic modeling of thymoglobulin[R] in children receiving allogeneic-hematopoietic cell transplantation: towards improved survival through individualized dosing

  Authors:Rick Admiraal, Charlotte van Kesteren, Cornelia M. Jol-van der Zijde, Maarten J. D. van Tol, Imke H. Bartelink, Robbert G. M. Bredius, et al.From:Clinical Pharmacokinetics (Vol. 54, Issue 4) Peer-Reviewed

  Apr. 2015 Report

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• Morbidly obese patients exhibit increased CYP2E1-mediated oxidation of acetaminophen

  Authors:Anne van Rongen, Pyry A. J. Valitalo, Mariska Y. M. Peeters, Djamila Boerma, Fokko W. Huisman, Bert van Ramshorst, et al.From:Clinical Pharmacokinetics (Vol. 55, Issue 7) Peer-Reviewed

  July 2016 Article

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• Developmental changes in the expression and function of cytochrome P450 3A isoforms: evidence from in vitro and in vivo investigations

  Authors:Ibrahim Ince, Catherijne A. J. Knibbe, Meindert Danhof, and Saskia N. de WildtFrom:Clinical Pharmacokinetics (Vol. 52, Issue 5) Peer-Reviewed

  May 2013 Article

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• Increased Metformin Clearance in Overweight and Obese Adolescents: A Pharmacokinetic Substudy of a Randomized Controlled Trial.

  Authors:Anne van Rongen, Marloes P. van der Aa, Maja Matic, Ron H. N. van Schaik, Vera H. M. Deneer, Marja M. van der Vorst, et al.From:Pediatric Drugs (Vol. 20, Issue 4) Peer-Reviewed

  Aug. 20187,120 words Report Background In view of the increased use of metformin in obese adolescents, the aim of this study was to determine the pharmacokinetics of metformin in overweight and obese adolescents. Methods In overweight and...

• Prediction of glomerular filtration rate maturation across preterm and term neonates and young infants using inulin as marker.

  Authors:Yunjiao Wu, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons, Elke H. J. Krekels, Catherijne A. J. Knibbe, et al.From:The AAPS Journal (Vol. 24, Issue 2) Peer-Reviewed

  Mar. 20227,702 words Report 1520LDescribing glomerular filtration rate (GFR) maturation across the heterogeneous population of preterm and term neonates and infants is important to predict the clearance of renally cleared drugs. This study aims to...

• A novel maturation function for clearance of the cytochrome P450 3A substrate midazolam from preterm neonates to adults

  Authors:Ibrahim Ince, Saskia N. de Wildt, Chengueng Wang, Mariska Y. M. Peeters, Jacobus Burggraaf, Evelyne Jacqz-Aigrain, et al.From:Clinical Pharmacokinetics (Vol. 52, Issue 7) Peer-Reviewed

  July 2013 Report

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• Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools

  Authors:Sebastiaan C. Goulooze, Elke H. J. Krekels, Thomas Hankemeier, and Catherijne A. J. KnibbeFrom:The AAPS Journal (Vol. 21, Issue 1) Peer-Reviewed

  Jan. 2019359 words Report

   Abstract Only

• A randomized controlled trial of daily sedation interruption in critically ill children.

  Authors:Nienke J. Vet, Saskia N. de Wildt, Carin W. M. Verlaat, Catherijne A. J. Knibbe, Miriam G. Mooij, Job B. M. van Woensel, et al.From:Intensive Care Medicine (Vol. 42, Issue 2) Peer-Reviewed

  Feb. 20166,418 words Article 1400LPurpose To compare daily sedation interruption plus protocolized sedation (DSI + PS) to protocolized sedation only (PS) in critically ill children. Methods In this multicenter randomized controlled trial in three...

• Towards evidence-based dosing regimens in children on the basis of population pharmacokinetic pharmacodynamic modelling

  Authors:Catherijne A. J. Knibbe, Dick Tibboel, Robbert G. M. Bredius, Jaap Jan Boelens, Charlotte van Kesteren, and Rick AdmiraalFrom:Archives of Disease in Childhood (Vol. 99, Issue 3) Peer-Reviewed

  Mar. 2014 Report

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• how to screen obese children at risk for type 2 diabetes mellitus?

  Authors:Marja M. J. Van der Vorst, Catherijne A. J. Knibbe, Anthonius de Boer, Lisa A. J. Kromwijk, Soulmaz Fazeli Farsani, and Marloes P. van der AaFrom:Clinical Pediatrics (Vol. 53, Issue 4) Peer-Reviewed

  Apr. 2014 Report

   Citation Only

• Chronic comorbidities in children with type 1 diabetes: a population-based cohort study

  Authors:Soulmaz Fazeli Farsani, Patrick C Souverein, Marja M J van der Vorst, Catherijne A J Knibbe, Anthonius de Boer, and Aukje K Mantel-TeeuwisseFrom:Archives of Disease in Childhood (Vol. 100, Issue 8) Peer-Reviewed

  Aug. 2015 Report

   Citation Only

• Prediction of morphine clearance in the paediatric population how accurate are the available pharmacokinetic models?

  Authors:Elke H. J. Krekels, Dick Tibboel, Meindert Danhof, and Catherijne A. J. KnibbeFrom:Clinical Pharmacokinetics (Vol. 51, Issue 11) Peer-Reviewed

  Nov. 2012 Report

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• Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method

  Authors:E. A. M. Calvier, E. H. J. Krekels, T. N. Johnson, A. Rostami-Hodjegan, D. Tibboel, and Catherijne A. J. KnibbeFrom:The AAPS Journal (Vol. 21, Issue 3) Peer-Reviewed

  May 2019413 words Report

   Abstract Only

• Predictive performance of a recently developed population pharmacokinetic model for morphine and its metabolites in new datasets of (preterm) neonates, infants and children

  Authors:Elke H.J. Krekels, Joost DeJongh, Richard A. van Lingen, Caroline D. van der Marel, Imti Choonara, Anne M. Lynn, et al.From:Clinical Pharmacokinetics (Vol. 50, Issue 1) Peer-Reviewed

  Jan. 20115,578 words Report 1680LBackground and Objective: Model validation procedures are crucial when models are to be used to develop new dosing algorithms. In this study, the predictive performance of a previously published paediatric population...