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    Academic Journals

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• Ceramide accumulation induces mitophagy and impairs [beta]-oxidation in PINK1 deficiency.

  Authors:Melissa Vos, Marija Dulovic-Mahlow, Frida Mandik, Lisa Frese, Yuliia Kanana, Sokhna Haissatou Diaw, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 118, Issue 43) Peer-Reviewed

  Oct. 26, 20217,839 words Report 1380L

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• No Association of the BDNF Val66met Polymorphism with Implicit Associative Vocabulary and Motor Learning

  Authors:Nils Freundlieb, Stephan Philipp, Susanne A. Schneider, Norbert Bruggemann, Christine Klein, Christian Gerloff, et al.From:PLoS ONE (Vol. 7, Issue 11) Peer-Reviewed

  Nov. 13, 20124,933 words Article 1350LAuthor(s): Nils Freundlieb 1 , Stephan Philipp 1 , Susanne A. Schneider 2 , Norbert Brüggemann 2 , Christine Klein 2 , Christian Gerloff 1 , Friedhelm C. Hummel 1 , * Introduction Brain-derived neurotrophic factor...

• Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly

  Authors:Tatsiana Aneichyk, William T. Hendriks, Rachita Yadav, David Shin, Dadi Gao, Christine A. Vaine, et al.From:Cell (Vol. 172, Issue 5) Peer-Reviewed

  Feb. 22, 2018602 words Report

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• Search for a founder mutation in idiopathic focal dystonia from northern Germany

  Authors:Christine Klein, Laurie J. Ozelius, Johann Hagenah, Xandra O. Breakerfield, Neil J. Risch, and Peter ViereggeFrom:American Journal of Human Genetics (Vol. 63, Issue 6) Peer-Reviewed

  Dec. 199865 words Article

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• Phenotypes and genetic architecture of focal primary torsion dystonia

  Authors:Justus L Groen, Ton P Langeveld, Frank Baas, Johannes H T M Koelman, Agnita J W Boon, Christine Klein, et al.From:Journal of Neurology, Neurosurgery and Psychiatry (Vol. 83, Issue 10) Peer-Reviewed

  Oct. 2012 Author abstract, Cli...

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• Mutant Parkin Impairs Mitochondrial Function and Morphology in Human Fibroblasts

  Authors:Anne Grunewald, Lisa Voges, Aleksandar Rakovic, Meike Kasten, Himesha Vandebona, Claudia Hemmelmann, et al.From:PLoS ONE (Vol. 5, Issue 9) Peer-Reviewed

  Sept. 27, 20104,401 words Article 1350LBackground Mutations in Parkin are the most common cause of autosomal recessive Parkinson disease (PD). The mitochondrially localized E3 ubiquitin-protein ligase Parkin has been reported to be involved in respiratory...

• The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism

  Authors:Stephan Klebe, Jean-Louis Golmard, Michael A Nalls, Mohamad Saad, Andrew B Singleton, Jose M Bras, et al.From:Journal of Neurology, Neurosurgery and Psychiatry (Vol. 84, Issue 6) Peer-Reviewed

  June 2013 Report

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• Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts

  Authors:Aleksandar Rakovic, Anne Grunewald, Jan Kottwitz, Norbert Bruggemann, Peter P. Pramstaller, Katja Lohmann, et al.From:PLoS ONE (Vol. 6, Issue 3) Peer-Reviewed

  Mar. 8, 20117,915 words Article 1360LPINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes...

• Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease

  Authors:Andrey Yurevich Abramov, Matthew Gegg, Anne Grunewald, Nicholas William Wood, Christine Klein, and Anthony Henry Vernon SchapiraFrom:PLoS ONE (Vol. 6, Issue 10) Peer-Reviewed

  Oct. 17, 20114,817 words Article 1460LBackground Mutations of the gene for PTEN-induced kinase 1 (PINK1) are a cause of familial Parkinson's disease (PD). PINK1 protein has been localised to mitochondria and PINK1 gene knockout models exhibit abnormal...

• Linkage analysis identifies a novel locus for restless legs syndrome on chromosome 2q in a South Tyrolean population isolate

  Authors:Irene Pichler, Fabio Marroni, Claudia Beu Volpato, James F. Gusella, Christine Klein, Giorgio Casari, et al.From:American Journal of Human Genetics (Vol. 79, Issue 4) Peer-Reviewed

  Oct. 200649 words Article

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• The promise and limitations of genome-wide association studies

  Authors:Christine Klein, Katja Lohmann, and Andreas ZieglerFrom:JAMA, The Journal of the American Medical Association (Vol. 308, Issue 18) Peer-Reviewed

  Nov. 14, 201240 words Viewpoint essay

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• Dichloroacetate prevents restenosis in preclinical animal models of vessel injury

  Authors:Tobias Deuse, Xiaoqin Hua, Dong Wang, Lars Maegdefessel, Joerg Heeren, Ludger Scheja, et al.From:Nature (Vol. 509, Issue 7502) Peer-Reviewed

  May 29, 20145,596 words Report 1380LDespite the introduction of antiproliferative drug-eluting stents, coronary heart disease remains the leading cause of death in the United States (1). In-stent restenosis and bypass graft failure are characterized by...

• Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model

  Authors:Daniel Alvarez-Fischer, Carmen Noelker, Franca Vulinovic, Anne Grunewald, Caroline Chevarin, Christine Klein, et al.From:PLoS ONE (Vol. 8, Issue 4) Peer-Reviewed

  Apr. 18, 20136,748 words Article 1500LBee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that bilateral acupoint stimulation of lower hind limbs with bee venom...

• EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts

  Authors:Johanna Huttenlocher, Rejko Kruger, Philipp Capetian, Katja Lohmann, Kathrin Brockmann, Ilona Csoti, et al.From:Journal of Medical Genetics (Vol. 52, Issue 1) Peer-Reviewed

  Jan. 2015 Report

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• PINK1-interacting proteins: proteomic analysis of overexpressed PINK1

  Authors:Aleksandar Rakovic, Anne Grunewald, Lisa Voges, Sarah Hoffmann, Slobodanka Orolicki, Katja Lohmann, et al.From:Parkinson's DiseasePeer-Reviewed

  Annual 20114,857 words Report 1350LRecent publications suggest that the Parkinson's disease- (PD-) related PINK1/Parkin pathway promotes elimination of dysfunctional mitochondria by autophagy. We used tandem affinity purification (TAP), SDS-PAGE, and...

• Pink1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

  Authors:Vanessa A. Morais, Dominik Haddad, Katleen Craessaerts, Pieter-Jan De Bock, Jef Swerts, Sven Vilain, et al.From:Science (Vol. 344, Issue 6180) Peer-Reviewed

  Apr. 11, 2014128 words Author abstract, Rep...

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• Mode of inheritance and susceptibility locus for restless legs syndrome, on chromosome 12q. (Letters to the Editor)

  Authors:Norman Kock, Biljana Culjkovic, Susanna Maniak, Karla Schilling, Birgitt Muller, Christine Zuhlke, et al.From:American Journal of Human Genetics (Vol. 71, Issue 1) Peer-Reviewed

  July 2002 Article

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• A study of visual hallucinations in patients with Parkinson's disease

  Authors:Christine Klein, Detlef Kompf, Ulrich Pulkowski, Andreas Moser, and Peter ViereggeFrom:Journal of Neurology (Vol. 244, Issue 6) Peer-Reviewed

  June 1997190 words Article

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• Evidence that paternal expression of the [epsilon]-sarcoglycan gene accounts for reduced penetrance in myoclonus-dystonia

  Authors:Birgitt Muller, Katja Hedrich, Norman Kock, Natasa Dragasevic, Marina Svetel, Jennifer Garrels, et al.From:American Journal of Human Genetics (Vol. 71, Issue 6) Peer-Reviewed

  Dec. 2002 Article

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• The Bioenergetic Status Relates to Dopamine Neuron Loss in Familial PD with PINK1 Mutations

  Authors:Ruediger Hilker, Ulrich Pilatus, Carsten Eggers, Johann Hagenah, Julia Roggendorf, Simon Baudrexel, et al.From:PLoS ONE (Vol. 7, Issue 12) Peer-Reviewed

  Dec. 10, 20124,604 words Article 1580LAuthor(s): Rüediger Hilker 1 , * , Ulrich Pilatus 2 , Carsten Eggers 3 , Johann Hagenah 4 , Julia Roggendorf 1 , Simon Baudrexel 1 , Johannes C. Klein 1 , Bernd Neumaier 5 , Gereon R. Fink 3 , Helmuth Steinmetz 1 ,...