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From:Journal of Clinical Investigation (Vol. 131, Issue 12) Peer-ReviewedTraumatic brain injury (TBI) is a chronic and progressive disease, and management requires an understanding of both the primary neurological injury and the secondary sequelae that affect peripheral organs, including the...
From:Neural Regeneration Research (Vol. 16, Issue 5) Peer-ReviewedByline: Rebecca. Henry, David. Loane Microglia, the resident innate immune cells of the central nervous system (CNS), play important roles in brain development, maintenance, and disease. As brain sentinels, microglia...
From:Neural Regeneration Research (Vol. 14, Issue 9) Peer-ReviewedByline: Kathryn. Wofford, David. Loane, D. Cullen Neuroinflammation is initiated as a result of traumatic brain injury and can exacerbate evolving tissue pathology. Immune cells respond to acute signals from damaged...
From:Nature Medicine (Vol. 15, Issue 4) Peer-ReviewedAmyloid-[beta] (A/[beta]) peptides, found in Alzheimer's disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either [beta]- or [gamma]-secretase,...
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