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    Academic Journals

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• Peptide-Pulsed Dendritic Cells Have Superior Ability to Induce Immune-Mediated Tissue Destruction Compared to Peptide with Adjuvant

  Authors:Dilan Dissanayake, Kiichi Murakami, Michael D. Tran, Alisha R. Elford, Douglas G. Millar, and Pamela S. OhashiFrom:PLoS ONE (Vol. 9, Issue 3) Peer-Reviewed

  Mar. 19, 20147,958 words Article 1640LAuthor(s): Dilan Dissanayake 1,2, Kiichi Murakami 1, Michael D. Tran 1, Alisha R. Elford 1, Douglas G. Millar 1, Pamela S. Ohashi 1,2,* Introduction Numerous studies have described the existence of tumor-specific...

• Dysregulation of Cell Polarity Proteins Synergize with Oncogenes or the Microenvironment to Induce Invasive Behavior in Epithelial Cells

  Authors:Samit Chatterjee, Laurie Seifried, Michael E. Feigin, Don L. Gibbons, Claudio Scuoppo, Wei Lin, et al.From:PLoS ONE (Vol. 7, Issue 4) Peer-Reviewed

  Apr. 18, 20128,579 words Article 1520LChanges in expression and localization of proteins that regulate cell and tissue polarity are frequently observed in carcinoma. However, the mechanisms by which changes in cell polarity proteins regulate carcinoma...

• Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

  Authors:Mahadeo A. Sukhai, Swayam Prabha, Rose Hurren, Angela C. Rutledge, Anna Y. Lee, Shrivani Sriskanthadevan, et al.From:Journal of Clinical Investigation (Vol. 123, Issue 1) Peer-Reviewed

  Jan. 20136,856 words Report 1460LDespite efforts to understand and treat acute myeloid leukemia (AML), there remains a need for more comprehensive therapies to prevent AML-associated relapses. To identify new therapeutic strategies for AML, we screened...

• Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

  Authors:Marc Pellegrini, Thomas Calzascia, Alisha R. Elford, Arda Shahinian, Amy E. Lin, Dilan Dissanayake, et al.From:Nature Medicine (Vol. 15, Issue 5) Peer-Reviewed

  May 20096,813 words Report 1480LIdentifying key factors that enhance immune responses is crucial for manipulating immunity to tumors. We show that after a vaccine-induced immune response, adjuvant interleukin-7 (IL-7) improves antitumor responses and...

• Different Toll-Like Receptor Stimuli Have a Profound Impact on Cytokines Required to Break Tolerance and Induce Autoimmunity

  Authors:Albert C. C. Lin, Dilan Dissanayake, Salim Dhanji, Alisha R. Elford, and Pamela S. OhashiFrom:PLoS ONE (Vol. 6, Issue 9) Peer-Reviewed

  Sept. 12, 20118,628 words Article 1610LAlthough toll-like receptor (TLR) signals are critical for promoting antigen presenting cell maturation, it remains unclear how stimulation via different TLRs influence dendritic cell (DC) function and the subsequent...

• Nuclear factor-[kappa]B1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells

  Authors:Dilan Dissanayake, Hakan Hall, Nancy Berg-Brown, Alisha R. Elford, Sara R. Hamilton, Kiichi Murakami, et al.From:Nature Medicine (Vol. 17, Issue 12) Peer-Reviewed

  Dec. 20114,579 words Article 1400LMature dendritic cells (DCs) are crucial for the induction of adaptive immune responses and perturbed DC homeostasis can result in autoimmune disease. Either uncontrolled expansion (1) or enhanced survival (2,3) of DCs...

• Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting [CD8.sup.+] T-cell immunity

  Authors:Philipp A. Lang, Karl S. Lang, Haifeng C. Xu, Melanie Grusdat, Ian A. Parish, Mike Recher, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 109, Issue 4) Peer-Reviewed

  Jan. 24, 2012 Author abstract, Rep...

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