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From:PLoS ONE (Vol. 4, Issue 4) Peer-ReviewedBackground Homeobox genes are essential for embryonic patterning and cell fate determination. They are regulated mostly at the transcriptional level. In particular, Prep1 regulates Hox transcription in association...
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From:Stem Cells International (Vol. 2017) Peer-ReviewedCell development is regulated by a complex network of mRNA-encoded proteins and microRNAs, all funnelling onto the modulation of self-renewal or differentiation genes. How intragenic microRNAs and their host genes are...
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From:Proceedings of the National Academy of Sciences of the United States (Vol. 101, Issue 29) Peer-ReviewedAbstract Only
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From:PLoS ONE (Vol. 14, Issue 2) Peer-ReviewedDuring preimplantation mouse development stages, emerging pluripotent epiblast (Epi) and extraembryonic primitive endoderm (PrE) cells are first distributed in the blastocyst in a "salt-and-pepper" manner before they...
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From:International Journal of Endocrinology (Vol. 2018) Peer-ReviewedThe circulating microRNAs (miRNAs) associated with type 2 diabetes (T2D) in elderly patients are still being defined. To identify novel miRNA biomarker candidates for monitoring responses to sitagliptin in such...
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From:Journal of Immunology ResearchPeer-ReviewedAcute lymphoblastic leukemia (ALL) is the most common cancer among children. Recent advances in chemotherapy have made ALL a curable hematological malignancy. In children, there is 25% chance of disease relapse,...
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From:Stem Cells InternationalPeer-ReviewedMedulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers. Among them, stem-like cells (hMB-SLCs) represent a fraction...
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From:Journal of Experimental & Clinical Cancer Research (Vol. 40, Issue 1) Peer-ReviewedBackground The yearly Think Tank Meeting of the Italian Network for Tumor Biotherapy (NIBIT) Foundation, brings together in Siena, Tuscany (Italy), experts in immuno-oncology to review the learnings from current...
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From:Journal of Clinical Investigation (Vol. 119, Issue 2) Peer-ReviewedGlucocorticoids (GCs) play a critical role in neural development; however, their prenatal or neonatal therapeutic use can have detrimental effects on the developing brain. In this issue of the JCI, Heine and Rowitch...
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From:Proceedings of the National Academy of Sciences of the United States (Vol. 104, Issue 19) Peer-ReviewedAbstract Only
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From:Stem Cells InternationalPeer-ReviewedMany central nervous system (CNS) diseases including stroke, spinal cord injury (SCI), and brain tumors are a significant cause of worldwide morbidity/mortality and yet do not have satisfying treatments. Cell-based...