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From:PLoS ONE (Vol. 12, Issue 6) Peer-ReviewedTo further our understanding of the somatic genetic basis of uveal melanoma, we sequenced the protein-coding regions of 52 primary tumors and 3 liver metastases together with paired normal DNA. Known recurrent mutations...
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From:Nature (Vol. 589, Issue 7843) Peer-ReviewedIt is time to move beyond tumour sequencing data to identify vulnerabilities in cancers. It is time to move beyond tumour sequencing data to identify vulnerabilities in cancers. Author(s): Jesse S. Boehm, Mathew J....
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From:Nature (Vol. 450, Issue 7170) Peer-ReviewedAuthor(s): John T. Cunningham [1, 2]; Joseph T. Rodgers [1]; Daniel H. Arlow [3]; Francisca Vazquez [1]; Vamsi K. Mootha (corresponding author) [3]; Pere Puigserver (corresponding author) [1, 2] Transcriptional...
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From:Journal of Clinical Investigation (Vol. 128, Issue 1) Peer-ReviewedPharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma, amplification of the oncogene MYCN is associated with...
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From:eLife (Vol. 6) Peer-ReviewedGenomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes...
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From:Nature Medicine (Vol. 20, Issue 3) Peer-ReviewedRecent studies have revealed that ARID1A, encoding AT-rich interactive domain 1A (SWI-like), is frequently mutated across a variety of human cancers and also has bona fide tumor suppressor properties. Consequently,...
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From:Nature (Vol. 510, Issue 7506) Peer-ReviewedAuthor(s): Yoonjin Lee [1, 2, 3]; John E. Dominy [1, 2]; Yoon Jong Choi [1, 4]; Michael Jurczak [5]; Nicola Tolliday [6]; Joao Paulo Camporez [5]; Helen Chim [1, 2]; Ji-Hong Lim [1, 2]; Hai-Bin Ruan [5]; Xiaoyong Yang...
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From:Proceedings of the National Academy of Sciences of the United States (Vol. 111, Issue 3) Peer-ReviewedAbstract Only
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From:Proceedings of the National Academy of Sciences of the United States (Vol. 106, Issue 2) Peer-ReviewedAbstract Only
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From:Nature (Vol. 537, Issue 7620) Peer-ReviewedAuthor(s): Chi Luo [1]; Ji-Hong Lim [1]; Yoonjin Lee [1, 2]; Scott R. Granter [3]; Ajith Thomas [1]; Francisca Vazquez [1, 4, 5]; Hans R. Widlund [6]; Pere Puigserver (corresponding author) [1] Melanoma is the...
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From:Proceedings of the National Academy of Sciences of the United States (Vol. 103, Issue 10) Peer-ReviewedAbstract Only
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From:Proceedings of the National Academy of Sciences of the United States (Vol. 96, Issue 5) Peer-ReviewedAbstract Only
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From:Journal of Clinical Investigation (Vol. 130, Issue 2) Peer-ReviewedOncogene-targeted and immune checkpoint the rapies have revolutionized the clinical management of malignant melanoma and now offer hope to patients with advanced disease. Intimately connected to patients' overall...
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From:Nature Medicine (Vol. 21, Issue 12) Peer-ReviewedThe authors identify EZH2 as a general underlying dependency of tumors with mutations in the SWI/SNF chromatin regulator complex, and they show that EZH2's pro-tumorigenic role may be dependent on non-catalytic...
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From:Nature Medicine (Vol. 21, Issue 12) Peer-ReviewedHuman cancer genome sequencing has recently revealed that genes that encode subunits of SWI/SNF chromatin remodeling complexes are frequently mutated across a wide variety of cancers, and several subunits of the complex...
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From:Nature (Vol. 450, Issue 7170) Peer-ReviewedTranscriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1[alpha] control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal...
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From:Nature Biotechnology (Vol. 34, Issue 5) Peer-ReviewedSystematic efforts to sequence the cancer genome have identified large numbers of mutations and copy number alterations in human cancers. However, elucidating the functional consequences of these variants, and their...