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• Computational tools for discovery and interpretation of expression quantitative trait loci

  Authors:Fred A Wright, Andrey A Shabalin, and Ivan RusynFrom:Pharmacogenomics (Vol. 13, Issue 3) Peer-Reviewed

  Feb. 20126,921 words Article 1510LAuthor(s): Fred A Wright 1 , Andrey A Shabalin 1 , Ivan Rusyn [**] 2 KEYWORDS : bioinformatics; fast linear modeling; gene expression Studies of the genetic basis of complex traits are contingent upon...

• Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics

  Authors:Kimmo Virtaneva, Fred A. Wright, Stephan M. Tanner, Bo Yuan, William J. Lemon, Michael A. Caligiuri, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 98, Issue 3) Peer-Reviewed

  Jan. 30, 2001172 words Article

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• The impact of rare variation on gene expression across tissues

  Authors:Xin Li, Yungil Kim, Emily K. Tsang, Joe R. Davis, Farhan N. Damani, Colby Chiang, et al.From:Nature (Vol. 550, Issue 7675) Peer-Reviewed

  Oct. 12, 201714,577 words Report 1480LAuthor(s): Xin Li [1]; Yungil Kim [2]; Emily K. Tsang [1, 3]; Joe R. Davis [1, 4]; Farhan N. Damani [2]; Colby Chiang [5]; Gaelen T. Hess [4]; Zachary Zappala [1, 4]; Benjamin J. Strober [6]; Alexandra J. Scott [5]; Amy...

• Prediction of human population responses to toxic compounds by a collaborative competition

  Authors:Federica Eduati, Lara M. Mangravite, Tao Wang, Hao Tang, J. Christopher Bare, Ruili Huang, et al.From:Nature Biotechnology (Vol. 33, Issue 9) Peer-Reviewed

  Sept. 20159,911 words Report 1550LThe ability to computationally predict the effects of toxic compounds on humans could help address the deficiencies of current chemical safety testing. Here, we report the results from a community-based DREAM challenge...

• Transformation of Sib-Pair Values for the Haseman-Elston Method

  Authors:Daolong Wang, Shili Lin, Rong Cheng, Xin Gao, and Fred A. WrightFrom:American Journal of Human Genetics (Vol. 68, Issue 5) Peer-Reviewed

  May 2001 Article

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• Racial differences in the incidence of cardiac arrest and subsequent survival

  Authors:Lance B. Becker, Ben H. Han, Peter M. Meyer, Fred A. Wright, Karin V. Rhodes, David W. Smith, et al.From:The New England Journal of Medicine (Vol. 329, Issue 9) Peer-Reviewed

  Aug. 26, 1993120 words Article

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• Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium

  Authors:Xu Tian, Keyur Patel, John R. Ridpath, Youjun Chen, Yi-Hui Zhou, Dayna Neo, et al.From:PLoS ONE (Vol. 11, Issue 12) Peer-Reviewed

  Dec. 1, 20167,558 words Report 1560LContamination of potentially carcinogenic hexavalent chromium (Cr(VI)) in the drinking water is a major public health concern worldwide. However, little information is available regarding the biological effects of a...

• Linkage disequilibrium mapping in isolated populations: the example of Finland revisited

  Authors:Albert De La Chappelle and Fred A. WrightFrom:Proceedings of the National Academy of Sciences of the United States (Vol. 95, Issue 21) Peer-Reviewed

  Oct. 13, 1998241 words Article

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• Estimating odds ratios in genome scans: an approximate conditional likelihood approach

  Authors:Arpita Ghosh, Fei Zou, and Fred A. WrightFrom:American Journal of Human Genetics (Vol. 82, Issue 5) Peer-Reviewed

  May 200835 words Article

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• A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents

  Authors:Hao Zhu, Lin Ye, Ann Richard, Alexander Golbraikh, Fred A. Wright, Ivan Rusyn, et al.From:Environmental Health Perspectives (Vol. 117, Issue 8) Peer-Reviewed

  Aug. 20097,673 words Article 1520LBACKGROUND: Accurate prediction of in vivo toxicity from in vitro testing is a challenging problem. Large public--private consortia have been formed with the goal of improving chemical safety assessment by the means of...

• Genetic modifiers of lung disease in cystic fibrosis

  Authors:Mitchell L. Drumm, Michael W. Konstan, Mark D. M Schluchter, Allison Handler, Rhonda Pace, Fei Zou, et al.From:The New England Journal of Medicine (Vol. 353, Issue 14) Peer-Reviewed

  Oct. 6, 200565 words Article

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• Gene expression in papillary thyroid carcinoma reveals highly consistent profiles

  Authors:Ying Huang, Manju Prasad, William J. Lemon, Heather Hampel, Fred A. Wright, Karl Kornacker, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 98, Issue 26) Peer-Reviewed

  Dec. 18, 2001236 words Abstract

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• The E2F1-3 transcription factors are essential for cellular proliferation

  Authors:Lizhao Wu, Cynthia Timmers, Baidehi Maiti, Harold I. Saavedra, Ling Sang, Gabriel T. Chong, et al.From:Nature (Vol. 414, Issue 6862) Peer-Reviewed

  Nov. 22, 20015,280 words Article 1620LAuthor(s): Lizhao Wu [1]; Cynthia Timmers [1]; Baidehi Maiti [1]; Harold I. Saavedra [1]; Ling Sang [1]; Gabriel T. Chong [1]; Faison Nuckolls [2]; Paloma Giangrande [2]; Fred A. Wright [1]; Seth J. Field [3]; Michael...

• A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening

  Authors:Fabian A. Grimm, Alexander Blanchette, John S. House, Kyle Ferguson, Nan-Hung Hsieh, Chimeddulam Dalaijamts, et al.From:ALTEX: Alternatives to Animal Experimentation (Vol. 35, Issue 4) Peer-Reviewed

  Fall 20187,353 words Report 1530LAssessing inter-individual variability in responses to xenobiotics remains a substantial challenge, both in drug development with respect to pharmaceuticals and in public health with respect to environmental chemicals....

• Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization.

  Authors:Melis Onel, Burcu Beykal, Kyle Ferguson, Weihsueh A. Chiu, Thomas J. McDonald, Lan Zhou, et al.From:PLoS ONE (Vol. 14, Issue 10) Peer-Reviewed

  Oct. 10, 20197,803 words Report 1580LA detailed characterization of the chemical composition of complex substances, such as products of petroleum refining and environmental mixtures, is greatly needed in exposure assessment and manufacturing. The inherent...

• Rapid Hazard Characterization of Environmental Chemicals Using a Compendium of Human Cell Lines from Different Organs.

  Authors:Zunwei Chen, Yizhong Liu, Fred A. Wright, Weihsueh A. Chiu, and Ivan RusynFrom:ALTEX: Alternatives to Animal Experimentation (Vol. 37, Issue 4) Peer-Reviewed

  Fall 20209,579 words Article 1580LThe lack of adequate toxicity data for the vast majority of chemicals in the environment has spurred the development of new approach methodologies (NAMs). This study aimed to develop a practical high-throughput in vitro...

• Grouping of UVCB Substances with New Approach Methodologies (NAMs) Data.

  Authors:John S. House, Fabian A. Grimm, William D. Klaren, Abigail Dalzell, Srikeerthana Kuchi, Shu-Dong Zhang, et al.From:ALTEX: Alternatives to Animal Experimentation (Vol. 38, Issue 1) Peer-Reviewed

  Wntr 20219,771 words Article 1530LOne of the most challenging areas in regulatory science is assessment of the substances known as UVCB (unknown or variable composition, complex reaction products and biological materials). Because the inherent complexity...

• Genetic modifiers of liver disease in cystic fibrosis

  Authors:Jaclyn R. Bartlett, Kenneth J. Friedman, Simon C. Ling, Rhonda G. Pace, Scott C. Bell, Giuseppe Castaldo, et al.From:JAMA, The Journal of the American Medical Association (Vol. 302, Issue 10) Peer-Reviewed

  Sept. 9, 200937 words Report

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• The human transcriptome across tissues and individuals

  Authors:Marta Mele, Pedro G. Ferreira, Ferran Reverter, David S. DeLuca, Jean Monlong, Michael Sammeth, et al.From:Science (Vol. 348, Issue 6235) Peer-Reviewed

  May 8, 2015136 words Author abstract, Rep...

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• Molecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes

  Authors:Vonn Walter, Xiaoying Yin, Matthew D. Wilkerson, Christopher R. Cabanski, Ni Zhao, Ying Du, et al.From:PLoS ONE (Vol. 8, Issue 2) Peer-Reviewed

  Feb. 22, 20137,990 words Article 1490LAuthor(s): Vonn Walter 1 , Xiaoying Yin 1 , 2 , Matthew D. Wilkerson 1 , Christopher R. Cabanski 1 , 3 , Ni Zhao 1 , 4 , Ying Du 1 , Mei Kim Ang 1 , 5 , Michele C. Hayward 1 , Ashley H. Salazar 1 , Katherine A. Hoadley...