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• Next Generation Vaccines for Infectious Diseases

  Authors:Giuseppe A. Sautto, Greg A. Kirchenbaum, Roberta A. Diotti, Elena Criscuolo, and Francesca FerraraFrom:Journal of Immunology ResearchPeer-Reviewed

  May 31, 2019721 words Article 1500LVaccines represent the most effective prophylactic strategy in our arsenal for controlling the spread of infectious diseases and have increased human life expectancy. As an example, the eradication of smallpox and the...

• Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes

  Authors:J. Benjamin St. Clair, Thiago Detanico, Katja Aviszus, Greg A. Kirchenbaum, Merry Christie, John F. Carpenter, et al.From:PLoS ONE (Vol. 12, Issue 1) Peer-Reviewed

  Jan. 23, 20179,783 words Article 1570LA paradox in monoclonal antibody (mAb) therapy is that despite the well-documented tolerogenic properties of deaggregated IgG, most therapeutic IgG mAb induce anti-mAb responses. To analyze CD4 T cell reactions against...

• Convergent antibody evolution and clonotype expansion following influenza virus vaccination.

  Authors:David Forgacs, Rodrigo B. Abreu, Giuseppe A. Sautto, Greg A. Kirchenbaum, Elliott Drabek, Kevin S. Williamson, et al.From:PLoS ONE (Vol. 16, Issue 2) Peer-Reviewed

  Feb. 22, 202111,612 words Report 1600LRecent advances in high-throughput single cell sequencing have opened up new avenues into the investigation of B cell receptor (BCR) repertoires. In this study, PBMCs were collected from 17 human participants vaccinated...

• Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.

  Authors:Rodrigo B. Abreu, Greg A. Kirchenbaum, Giuseppe A. Sautto, Emily F. Clutter, and Ted M. RossFrom:PLoS ONE (Vol. 16, Issue 8) Peer-Reviewed

  Aug. 5, 202110,818 words Report 1600LInfluenza is a highly contagious viral respiratory disease that affects million of people worldwide each year. Annual vaccination is recommended by the World Health Organization with the goal of reducing influenza...

• γδ T cells affect IL-4 production and B-cell tolerance.

  Authors:Yafei Huang, Ryan A. Heiser, Thiago O. Detanico, Andrew Getahun, Greg A. Kirchenbaum, Tamara L. Casper, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 112, Issue 1) Peer-Reviewed

  Jan. 6, 20157,903 words Report 1520L

   Abstract Only

• Generation of Monoclonal Antibodies against Immunoglobulin Proteins of the Domestic Ferret (Mustela putorius furo)

  Authors:Greg A. Kirchenbaum and Ted M. RossFrom:Journal of Immunology Research (Vol. 2017) Peer-Reviewed

  Annual 20178,979 words Article 1580LThe domestic ferret (Mustela putorius furo) serves as an animal model for the study of several viruses that cause human disease, most notably influenza. Despite the importance of this animal model, characterization of...