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    Academic Journals

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• Functionally distinct patterns of nucleosome remodeling at enhancers in glucocorticoid-treated acute lymphoblastic leukemia

  Authors:Jennifer N. Wu, Luca Pinello, Elinor Yissachar, Jonathan W. Wischhusen, Guo-Cheng Yuan, and Charles W. M. RobertsFrom:Epigenetics & Chromatin (Vol. 8, Issue 1) Peer-Reviewed

  Dec. 2, 20159,801 words Article 1530LBackground Precise nucleosome positioning is an increasingly recognized feature of promoters and enhancers, reflecting complex contributions of DNA sequence, nucleosome positioning, histone modification and...

• Identification of spatially associated subpopulations by combining scRNAseq and sequential fluorescence in situ hybridization data

  Authors:Qian Zhu, Sheel Shah, Ruben Dries, Long Cai, and Guo-Cheng YuanFrom:Nature Biotechnology (Vol. 36, Issue 12) Peer-Reviewed

  Dec. 20189,295 words Report 1460LHow intrinsic gene-regulatory networks interact with a cell's spatial environment to define its identity remains poorly understood. We developed an approach to distinguish between intrinsic and extrinsic effects on...

• Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice

  Authors:Suzanne M. Cloonan, Kimberly Glass, Maria E. Laucho-Contreras, Abhiram R. Bhashyam, Morgan Cervo, Maria A. Pabon, et al.From:Nature Medicine (Vol. 22, Issue 2) Peer-Reviewed

  Feb. 201615,297 words Report 1550LChronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD...

• Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling.

  Authors:Yuxuan Guo, Yangpo Cao, Blake D. Jardin, Isha Sethi, Qing Ma, Behzad Moghadaszadeh, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 118, Issue 2) Peer-Reviewed

  Jan. 12, 20217,890 words Report 1340L

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• Modeling the Dynamics of Bivalent Histone Modifications

  Authors:Wai Lim Ku, Michelle Girvan, Guo-Cheng Yuan, Francesco Sorrentino, and Edward OttFrom:PLoS ONE (Vol. 8, Issue 11) Peer-Reviewed

  Nov. 1, 20139,347 words Report 1630LAuthor(s): Wai Lim Ku 1,2,*, Michelle Girvan 1,2,3, Guo-Cheng Yuan 4,5, Francesco Sorrentino 6, Edward Ott 1,2,7 Introduction Histones can undergo various types of covalent modifications, such as methylation and...

• Mapping the Mouse Cell Atlas by Microwell-Seq

  Authors:Xiaoping Han, Renying Wang, Yincong Zhou, Lijiang Fei, Huiyu Sun, Shujing Lai, et al.From:Cell (Vol. 172, Issue 5) Peer-Reviewed

  Feb. 22, 2018502 words Report

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• Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells

  Authors:Unmesh Jadhav, Kodandaramireddy Nalapareddy, Madhurima Saxena, Nicholas K. O'Neill, Luca Pinello, Guo-Cheng Yuan, et al.From:Cell (Vol. 165, Issue 6) Peer-Reviewed

  June 2, 2016382 words Article

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• Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity

  Authors:Lucas Ferrari de Andrade, Rong En Tay, Deng Pan, Adrienne M. Luoma, Yoshinaga Ito, Soumya Badrinath, et al.From:Science (Vol. 359, Issue 6383) Peer-Reviewed

  Mar. 30, 2018134 words Author abstract, Rep...

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• Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

  Authors:Nan Liu, Victoria V. Hargreaves, Qian Zhu, Jesse V. Kurland, Jiyoung Hong, Woojin Kim, et al.From:Cell (Vol. 173, Issue 2) Peer-Reviewed

  Apr. 5, 2018424 words Report

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• An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level

  Authors:Daniel E. Bauer, Sophia C. Kamran, Samuel Lessard, Jian Xu, Yuko Fujiwara, Carrie Lin, et al.From:Science (Vol. 342, Issue 6155) Peer-Reviewed

  Oct. 11, 2013127 words Author abstract, Rep...

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• Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases

  Authors:Jing Ni, Shakti H. Ramkissoon, Shaozhen Xie, Shom Goel, Daniel G. Stover, Hanbing Guo, et al.From:Nature Medicine (Vol. 22, Issue 7) Peer-Reviewed

  July 20164,320 words Report 1530LBrain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived xenografts (PDXs) of HER2-expressing breast cancer brain...

• Chromatin States Accurately Classify Cell Differentiation Stages

  Authors:Jessica L. Larson and Guo-Cheng YuanFrom:PLoS ONE (Vol. 7, Issue 2) Peer-Reviewed

  Feb. 20, 20126,767 words Article 1390LGene expression is controlled by the concerted interactions between transcription factors and chromatin regulators. While recent studies have identified global chromatin state changes across cell-types, it remains...

• Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy

  Authors:Adrienne M. Luoma, Shengbao Suo, Hannah L. Williams, Tatyana Sharova, Keri Sullivan, Michael Manos, et al.From:Cell (Vol. 182, Issue 3) Peer-Reviewed

  Aug. 6, 2020454 words Report

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• TGF-[beta] signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond syndrome.

  Authors:Cailin E. Joyce, Assieh Saadatpour, Melisa Ruiz-Gutierrez, Ozge Vargel Bolukbasi, Lan Jiang, Dolly D. Thomas, et al.From:Journal of Clinical Investigation (Vol. 129, Issue 9) Peer-Reviewed

  Sept. 20194,052 words Article 1350LShwachman-Diamond syndrome (SDS) is a rare and clinically heterogeneous bone marrow (BM) failure syndrome caused by mutations in the Shwachman-Bodian-Diamond syndrome (SBDS) gene. Although SDS was described more than 50...

• High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

  Authors:Semir Beyaz, Miyeko D. Mana, Jatin Roper, Dmitriy Kedrin, Assieh Saadatpour, Sue-Jean Hong, et al.From:Nature (Vol. 531, Issue 7592) Peer-Reviewed

  Mar. 3, 201612,904 words Report 1580LLittle is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5[sup.+] intestinal stem cells...

• The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing

  Authors:Cary Stelloh, Michael H. Reimer, Kirthi Pulakanti, Steven Blinka, Jonathan Peterson, Luca Pinello, et al.From:Epigenetics & Chromatin (Vol. 9, Issue 14) Peer-Reviewed

  Apr. 15, 201612,416 words Report 1450LBackground The cohesin complex consists of multiple core subunits that play critical roles in mitosis and transcriptional regulation. The cohesin-associated protein Wapal plays a central role in off-loading cohesin...

• Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

  Authors:Joep Grootjans, Niklas Krupka, Shuhei Hosomi, Juan D. Matute, Thomas Hanlcy, Svetlana Saveljeva, et al.From:Science (Vol. 363, Issue 6430) Peer-Reviewed

  Mar. 1, 20194,445 words Article 1500L

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• CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

  Authors:Edmond Chipumuro, Eugenio Marco, Camilla L. Christensen, Nicholas Kwiatkowski, Tinghu Zhang, Clark M. Hatheway, et al.From:Cell (Vol. 159, Issue 5) Peer-Reviewed

  Nov. 20, 2014397 words Article

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• Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis.

  Authors:Arnaud Chastanet, Dennis Vitkup, Guo-Cheng Yuan, Thomas M. Norman, Jun S. Liu, and Richard M. LosickFrom:Proceedings of the National Academy of Sciences of the United States (Vol. 107, Issue 18) Peer-Reviewed

  May 4, 2010227 words Report, Author abstr...

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• Single-cell nuclear architecture across cell types in the mouse brain.

  Authors:Yodai Takei, Shiwei Zheng, Jina Yun, Sheel Shah, Nico Pierson, Jonathan White, et al.From:Science (Vol. 374, Issue 6567) Peer-Reviewed

  Oct. 29, 20215,126 words Article 1550L

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