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From:Expert Review of Cardiovascular Therapy (Vol. 7, Issue 3) Peer-ReviewedAuthor(s): Yoonjung Park 1 , Junxi Wu 2 , Hanrui Zhang 3 , Yong Wang 4 , Cuihua Zhang [[dagger]] 5 Vascular dysfunction associated with Type 2 diabetes is initially manifested in the prediabetic condition and...
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From:PLoS ONE (Vol. 12, Issue 1) Peer-ReviewedCalgranulin genes (S100A8, S100A9 and S100A12) play key immune response roles in inflammatory disorders, including cardiovascular disease. Long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) may have systemic...
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From:Expert Review of Endocrinology & Metabolism (Vol. 5, Issue 1) Peer-ReviewedAuthor(s): Frank A DeLano 1 , Hanrui Zhang 2 , Edward E Tran 3 , Cuihua Zhang 4 , Geert W Schmid-Schönbein [[dagger]] 5 Keywords : adhesion; insulin resistance; integrin; leukocyte; matrix metalloproteases;...
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From:Expert Review of Endocrinology & Metabolism (Vol. 5, Issue 1) Peer-ReviewedBackground: One of the most important unresolved issues in diabetes is the mechanism for the attenuated response to insulin (i.e., insulin resistance). Aims and methods: We hypothesize that the mechanism for insulin...
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From:PLoS ONE (Vol. 12, Issue 11) Peer-ReviewedObjectives Inflammatory cytokines, such as tumor necrosis factor-[alpha] (TNF-[alpha]) and interleukin-6 (IL-6), are individually considered as important contributors to endothelial dysfunction in obesity and type 2...
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From:Journal of Clinical Investigation (Vol. 131, Issue 8) Peer-Reviewed
Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis.
Efferocytosis, the process through which apoptotic cells (ACs) are cleared through actin-mediated engulfment by macrophages, prevents secondary necrosis, suppresses inflammation, and promotes resolution. Impaired... -
From:Proceedings of the National Academy of Sciences of the United States (Vol. 112, Issue 23) Peer-ReviewedAbstract Only