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From:Journal of Clinical Investigation (Vol. 131, Issue 13) Peer-ReviewedThe upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-2 tropism at the cellular level is not fully defined. Unlike recent single-cell RNA-Seq analyses indicating uniformly low mRNA...
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From:Journal of Clinical Investigation (Vol. 127, Issue 10) Peer-ReviewedPrimary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemm's canal (SC), a...
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From:Journal of Clinical Investigation (Vol. 127, Issue 9) Peer-ReviewedAngiogenesis is a multistep process that requires coordinated migration, proliferation, and junction formation of vascular endothelial cells (ECs) to form new vessel branches in response to growth stimuli. Major...
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From:Journal of Clinical Investigation (Vol. 128, Issue 11) Peer-ReviewedEmerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. However, its precise role in postischemic...