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From:PLoS ONE (Vol. 8, Issue 9) Peer-ReviewedIntrinsic drug resistance of pancreatic ductal adenocarcinoma (PDAC) warrants studies using models that are more clinically relevant for identifying novel resistance mechanisms as well as for drug development. Tumor...
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From:Archives of Pharmacal Research (Vol. 38, Issue 2) Peer-Reviewed
Indirect modulation of sensitivity to 5-fluorouracil by microRNA-96 in human colorectal cancer cells
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From:Journal of Experimental & Clinical Cancer Research (Vol. 37, Issue 1) Peer-ReviewedAuthor(s): Ji-Hyun Lee1 , Seul-Ki Kim1 , Iftikhar Ali Khawar1 , Su-Yeong Jeong1 , Seok Chung2 and Hyo-Jeong Kuh1,3 Background Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of...
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From:PLoS ONE (Vol. 11, Issue 7) Peer-ReviewedMulticellular 3D culture and interaction with stromal components are considered essential elements in establishing a 'more clinically relevant' tumor model. Matrix-embedded 3D cultures using a microfluidic chip platform...
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From:Journal of Experimental & Clinical Cancer Research (Vol. 38, Issue 1) Peer-ReviewedBackground Pancreatic ductal adenocarcinoma (PDAC) is a stroma-rich carcinoma, and pancreatic stellate cells (PSCs) are a major component of this dense stroma. PSCs play significant roles in metastatic progression...