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From:Mayo Clinic Proceedings (Vol. 92, Issue 1) Peer-ReviewedAbstract Objective: To assess whether athletes who played American varsity high school football between 1956 and 1970 have an increased risk of neurodegenerative diseases later in life. Patients and Methods: We...
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From:Mayo Clinic Proceedings (Vol. 84, Issue 4) Peer-ReviewedOBJECTIVE: To determine the frequency of new-onset compulsive gambling or hypersexuality among regional patients with Parkinson disease (PD), ascertaining the relationship of these behaviors to PD drug use. PATIENTS...
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From:Parkinson's DiseasePeer-ReviewedObjective. Autonomic symptoms are common in [alpha]-synuclein disorders: multiple system atrophy (MSA), Parkinson's disease (PD), dementia with Lewy bodies (DLB), and Parkinson's disease with dementia (PDD). These...
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From:Mayo Clinic Proceedings (Vol. 87, Issue 4) Peer-ReviewedAbstract Objective: To assess whether high school football played between 1946 and 1956, when headgear was less protective than today, was associated with development of neurodegenerative diseases later in life....
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From:Mayo Clinic Proceedings (Vol. 96, Issue 3) Peer-ReviewedAbstract Multiple system atrophy (MSA) is a neurodegenerative disorder primarily characterized by autonomic failure plus parkinsonism or cerebellar ataxia. The diagnosis may be challenging and is usually made at a...
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From:Mayo Clinic Proceedings (Vol. 95, Issue 10) Peer-ReviewedAbstract Parkinson disease symptoms become apparent when there has been substantial loss of brain dopamine. That is the consequence of the slow progression of the Lewy body neurodegenerative process. Replenishment of...
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From:Mayo Clinic Proceedings (Vol. 89, Issue 7) Peer-ReviewedAbstract The unique needs of patients with Parkinson disease challenge staff when such patients are admitted to hospitals or nursing facilities. Prolongation of the hospital stay, falls with injuries, fainting, or...
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From:PLoS ONE (Vol. 3, Issue 1) Peer-ReviewedBackground We recently described a genomic pathway approach to study complex diseases. We demonstrated that models constructed using single nucleotide polymorphisms (SNPs) within axon guidance pathway genes were...
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From:Formulary (Vol. 35, Issue 8) Peer-ReviewedABSTRACT After several years of Parkinson's disease (PD), most levodopa-treated patients begin to experience motor complications, ie, clinical fluctuations and dyskinesias. The motor fluctuations relate to the...
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From:Mayo Clinic Proceedings (Vol. 86, Issue 9) Peer-ReviewedA rapidly growing literature strongly suggests that exercise, specifically aerobic exercise, may attenuate cognitive impairment and reduce dementia risk. We used PubMed (keywords exercise and cognition) and manuscript...
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From:Journal of Neurology, Neurosurgery and Psychiatry (Vol. 83, Issue 4) Peer-ReviewedCitation Only
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From:Mayo Clinic Proceedings (Vol. 94, Issue 9) Peer-ReviewedAbstract Objective: To compare survival by the presenting parkinsonism symptoms at diagnosis among patients with incident clinically diagnosed synucleinopathies. Patients and Methods: Using the Rochester Epidemiology...
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From:Mayo Clinic Proceedings (Vol. 86, Issue 12) Peer-ReviewedOn completion of this article, you should be able to (1) formulate an initial medication plan for patients with Parkinson disease, (2) understand the rationale for treating levodopa-associated motor fluctuations and...
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From:Mayo Clinic Proceedings (Vol. 93, Issue 3) Peer-ReviewedAbstract No medications are proven to slow the progression of Parkinson disease (PD). Of special concern with longer-standing PD is cognitive decline, as well as motor symptoms unresponsive to dopamine replacement...
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From:Journal of Medical Speech - Language Pathology (Vol. 11, Issue 3) Peer-ReviewedCorticobasal degeneration (CBD) is a neurodegenerative disease characterized by asymmetric cortical and extrapyramidal signs including progressive asymmetric limb rigidity and apraxia. Other commonly occurring signs...