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From:Journal of Clinical Investigation (Vol. 127, Issue 10) Peer-ReviewedPrimary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemm's canal (SC), a...
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From:PLoS ONE (Vol. 14, Issue 6) Peer-ReviewedPurpose To investigate the factors affecting axial length (AXL) growth and myopia progression in orthokeratology. Methods This prospective, observational study enrolled 28 new orthokeratology lens wearers from...
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From:Journal of Clinical Investigation (Vol. 127, Issue 9) Peer-ReviewedAngiogenesis is a multistep process that requires coordinated migration, proliferation, and junction formation of vascular endothelial cells (ECs) to form new vessel branches in response to growth stimuli. Major...
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From:Journal of Clinical Investigation (Vol. 130, Issue 3) Peer-ReviewedMutations in APC promote colorectal cancer (CRC) progression through uncontrolled WNT signaling. Patients with desmoplastic CRC have a significantly worse prognosis and do not benefit from chemotherapy, but the...