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From:Journal of Immunology Research (Vol. 2022) Peer-ReviewedIL-28B, belonging to type III interferons (IFN-λ s), exhibits a potent antitumor activity with reduced regulated T cells (Tregs) population, yet the effect of IL-28B on the tumor microenvironment (TME) and if IL-28B can...
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From:Proceedings of the National Academy of Sciences of the United States (Vol. 108, Issue 22) Peer-ReviewedAbstract Only
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From:Future Rheumatology (Vol. 2, Issue 5) Peer-ReviewedAuthor(s): Jianghua Wang 1 , Shen Hu 2 , David T Wong [[dagger]] 3 Primary Sjögren's Syndrome (pSS) is characterized by lymphoid infiltrates, mainly in the lacrimal and salivary glands, and impaired secretory...
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From:PLoS ONE (Vol. 7, Issue 6) Peer-ReviewedAuthor(s): Zhongsheng Guo 1 , 2 , Henghui Zhang 1 , 2 , Huiying Rao 1 , 2 , Dong Jiang 1 , 2 , Xu Cong 1 , 2 , Bo Feng 1 , 2 , Jianghua Wang 1 , 2 , Lai Wei 1 , 2 , * , Hongsong Chen 1 , 2 Introduction Chronic...
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From:Journal of Clinical Investigation (Vol. 126, Issue 7) Peer-ReviewedAlthough Notch signaling Is deregulated In prostate cancer, the role of this pathway In disease development and progression Is not fully understood. Here, we analyzed 2 human prostate cancer data sets and found that...
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From:PLoS ONE (Vol. 7, Issue 2) Peer-ReviewedProstate cancer is the most common visceral malignancy in Western men and a major cause of cancer deaths. Increased activation of the AKT and NFkB pathways have been identified as critical steps in prostate cancer...
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From:Proceedings of the National Academy of Sciences of the United States (Vol. 101, Issue 9) Peer-ReviewedAbstract Only
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From:PLoS ONE (Vol. 8, Issue 1) Peer-ReviewedThe worldwide occurrence of cyanobacterial blooms evokes profound concerns. The presence of microcystins (MCs) in waters and aquatic food increases the risk to human health. Some recent studies have suggested that the...
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From:PLoS ONE (Vol. 8, Issue 3) Peer-ReviewedThe TMPRSS2/ERG (T/E) fusion gene is present in the majority of all prostate cancers (PCa). We have shown previously that NF-kB signaling is highly activated in these T/E fusion expressing cells via phosphorylation of...
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From:PLoS ONE (Vol. 6, Issue 6) Peer-ReviewedProstate specific membrane antigen (PSMA) is overexpressed in prostatic adenocarcinoma (CaP), and its expression is negatively regulated by androgen stimulation. However, it is still unclear which factors are involved...
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From:Journal of Clinical Investigation (Vol. 125, Issue 3) Peer-Reviewed
Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis
Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cells. The underlying regulators of the tumor metabolic program...