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    Academic Journals

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• Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways.

  Authors:Liang Cheng, Bin Yan, Ke Chen, Zhengdong Jiang, Cancan Zhou, Junyu Cao, et al.From:Oxidative Medicine and Cellular Longevity (Vol. 2018) Peer-Reviewed

  Annual 20188,430 words Article 1410LNAF-1 (nutrient-deprivation autophagy factor-1), which is an outer mitochondrial membrane protein, is known to play important roles in calcium metabolism, antiapoptosis, and antiautophagy. Resveratrol, a natural...

• Nitric Oxide Stimulates Acute Pancreatitis Pain via Activating the NF[kappa]B Signaling Pathway and Inhibiting the Kappa Opioid Receptor.

  Authors:Mengwen Xue, Liang Han, Weikun Qian, Jie Li, Tao Qin, Ying Xiao, et al.From:Oxidative Medicine and Cellular LongevityPeer-Reviewed

  May 31, 20206,614 words Article 1360LPain is the most important clinical feature of acute pancreatitis (AP); however, its specific mechanism is currently unclear. In this study, we showed that AP caused an increase in nitric oxide (NO) secretion, activated...

• The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer.

  Authors:Weikun Qian, Ke Chen, Tao Qin, Ying Xiao, Jie Li, Yangyang Yue, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 40, Issue 1) Peer-Reviewed

  Jan. 9, 20219,939 words Article 1700LBackground Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant diseases because of its non-symptomatic tumorigenesis. We previous found heat shock factor 1 (HSF1) was critical for PDAC progression and...

• High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer

  Authors:Cancan Zhou, Weikun Qian, Jie Li, Jiguang Ma, Xin Chen, Zhengdong Jiang, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 38, Issue 1) Peer-Reviewed

  July 11, 20195,524 words Report 1480LBackground Diabetes is recognized to be a risk factor of pancreatic cancer, but the mechanism has not been fully elucidated. Sterol regulatory element binding protein 1 (SREBP1) is an important transcription factor...

• Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-[beta]1 signaling in pancreatic cancer

  Authors:Liang Zong, Ke Chen, Zhengdong Jiang, Xin Chen, Liankang Sun, Jiguang Ma, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 36, Issue 1) Peer-Reviewed

  Dec. 11, 20175,676 words Article 1410LBackground Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is...

• The relevance of Nrf2 pathway and autophagy in pancreatic cancer cells upon stimulation of reactive oxygen species

  Authors:Lun Zhang, Jiahui Li, Jiguang Ma, Xin Chen, Ke Chen, Zhengdong Jiang, et al.From:Oxidative Medicine and Cellular Longevity (Vol. 2015) Peer-Reviewed

  Annual 20155,778 words Article 1440LNrf2 (NF-E2-related factor 2) pathway and autophagy both can respond to oxidative stress to promote cancer cells to survive in the tumor microenvironment. We, therefore, explored the relevance between Nrf2 pathway and...

• Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21.

  Authors:Bin Yan, Liang Cheng, Zhengdong Jiang, Ke Chen, Cancan Zhou, Liankang Sun, et al.From:Oxidative Medicine and Cellular Longevity (Vol. 2018) Peer-Reviewed

  Annual 20187,709 words Article 1500LActivation of pancreatic stellate cells (PSCs) initiates pancreatic fibrosis in chronic pancreatitis and furnishes a niche that enhances the malignancy of pancreatic cancer cells (PCCs) in pancreatic ductal...