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From:Journal of Experimental & Clinical Cancer Research (Vol. 40, Issue 1) Peer-ReviewedSolid tumors often grow in a micro-environment characterized by < 2% O.sub.2 tension. This condition, together with the aberrant activation of specific oncogenic patwhays, increases the amount and activity of the...
From:Journal of the National Cancer Institute (Vol. 107, Issue 5) Peer-ReviewedAbstract Only
From:PLoS ONE (Vol. 10, Issue 5) Peer-ReviewedBackground Multidrug resistant cancer cells are hard to eradicate for the inefficacy of conventional anticancer drugs. Besides escaping the cytotoxic effects of chemotherapy, they also bypass the pro-immunogenic...
From:PLoS ONE (Vol. 8, Issue 4) Peer-ReviewedDurable tumor cell eradication by chemotherapy is challenged by the development of multidrug-resistance (MDR) and the failure to induce immunogenic cell death. The aim of this work was to investigate whether MDR and...
From:Journal of Experimental & Clinical Cancer Research (Vol. 37, Issue 1) Peer-ReviewedBackground Triple negative breast cancer (TNBC) easily develops resistance to the first-line drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein (Pgp) and the activation of...
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