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From:Journal of Clinical Investigation (Vol. 130, Issue 6) Peer-ReviewedThe molecular mechanisms responsible for the high immunosuppressive capacity of [CD4.sup.+] Tregs in tumors are not well known. High-dimensional single-cell profiling of T cells from chemotherapy-naive individuals with...
From:PLoS ONE (Vol. 11, Issue 10) Peer-ReviewedEffective immunity against Bordetella pertussis is currently under discussion following the stacking evidence of pertussis resurgence in the vaccinated population. Natural immunity is more effective than vaccine-induced...
From:PLoS ONE (Vol. 13, Issue 5) Peer-ReviewedAluminum-based adjuvants have widely been used in human vaccines since 1926. In the absence of antigens, aluminum-based adjuvants can initiate the inflammatory preparedness of innate cells, yet the impact of antigens on...
From:PLoS ONE (Vol. 9, Issue 8) Peer-ReviewedWorldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies. Since natural infections induce a longer-lasting immunity than vaccinations, detailed knowledge...
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