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From:PLoS ONE (Vol. 7, Issue 8) Peer-ReviewedDNA damage induced by the topoisomerase I inhibitor SN38 activates cell cycle checkpoints which promote cell cycle arrest. This arrest can be abrogated in p53-defective cells by the Chk1 inhibitor 7-hydroxystaurosporine...
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From:PLoS ONE (Vol. 13, Issue 1) Peer-ReviewedAuthor(s): Yoon Suk Jung 1, Chan Hyuk Park 2,*, Nam Hee Kim 3, Jung Ho Park 1, Dong Il Park 1, Chong Il Sohn 1 Introduction Colorectal cancer (CRC) is the third most common cancer in men and the second most common...