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    Academic Journals

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• The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways.

  Authors:Seth A. Domfeh, Patrick W. Narkwa, Osbourne Quaye, Kwadwo A. Kusi, Bright S. Addy, Sian Lant, et al.From:Journal of Immunology Research (Vol. 2022) Peer-Reviewed

  July 26, 20227,967 words Article 1300LType 1 interferons (IFN-1) are pleiotropic cytokines with well-established anticancer and antiviral properties, particularly in mucosal tissues. Hence, natural IFN-1-inducing treatments are highly sought after in the...

• Impact of an Irrigation Dam on the Transmission and Diversity of Plasmodium falciparum in a Seasonal Malaria Transmission Area of Northern Ghana.

  Authors:Eric Kyei-Baafour, Bernard Tornyigah, Benjamin Buade, Langbong Bimi, Abraham R. Oduro, Kwadwo A. Koram, et al.From:Journal of Tropical MedicinePeer-Reviewed

  Mar. 31, 20205,591 words Article 1490LWater bodies such as dams are known to alter the local transmission patterns of a number of infectious diseases, especially those transmitted by insects and other arthropod vectors. The impact of an irrigation dam on...

• Seroprevalence of Antibodies against Plasmodium falciparum Sporozoite Antigens as Predictive Disease Transmission Markers in an Area of Ghana with Seasonal Malaria Transmission

  Authors:Kwadwo A. Kusi, Samuel Bosomprah, Eric Kyei-Baafour, Emmanuel K. Dickson, Bernard Tornyigah, Evelina Angov, et al.From:PLoS ONE (Vol. 11, Issue 11) Peer-Reviewed

  Nov. 22, 20166,997 words Article 1680LIntroduction As an increasing number of malaria-endemic countries approach the disease elimination phase, sustenance of control efforts and effective monitoring are necessary to ensure success. Mathematical models...

• Humoral Immune Response to Mixed PfAMA1 Alleles; Multivalent PfAMA1 Vaccines Induce Broad Specificity

  Authors:Kwadwo A. Kusi, Bart W. Faber, Alan W. Thomas, and Edmond J. RemarqueFrom:PLoS ONE (Vol. 4, Issue 12) Peer-Reviewed

  Dec. 1, 20098,879 words Article 1690LAuthor(s): Kwadwo A. Kusi 1,2, Bart W. Faber 1, Alan W. Thomas 1,*, Edmond J. Remarque 1 Introduction Malaria continues to be one of the most important human parasitic diseases, with a global estimate of about 247...

• Variations in the quality of malaria-specific antibodies with transmission intensity in a seasonal malaria transmission area of Northern Ghana

  Authors:Kwadwo A. Kusi, Emmanuel A. Manu, Theresa Manful Gwira, Eric Kyei-Baafour, Emmanuel K. Dickson, Jones A. Amponsah, et al.From:PLoS ONE (Vol. 12, Issue 9) Peer-Reviewed

  Sept. 25, 20179,221 words Report 1700LIntroduction Plasmodium falciparum induced antibodies are key components of anti-malarial immunity in malaria endemic areas, but their antigen targets can be polymorphic. Induction of a high proportion of...

• High Plasma Levels of Soluble Intercellular Adhesion Molecule (ICAM)-1 Are Associated with Cerebral Malaria

  Authors:Selorme Adukpo, Kwadwo A. Kusi, Michael F. Ofori, John K. A. Tetteh, Daniel Amoako-Sakyi, Bamenla Q. Goka, et al.From:PLoS ONE (Vol. 8, Issue 12) Peer-Reviewed

  Dec. 27, 20135,291 words Article 1700LBackground Cerebral malaria (CM) is responsible for most of the malaria-related deaths in children in sub-Saharan Africa. Although, not well understood, the pathogenesis of CM involves parasite and host factors which...

• Generation of Humoral Immune Responses to Multi-Allele PfAMA1 Vaccines; Effect of Adjuvant and Number of Component Alleles on the Breadth of Response

  Authors:Kwadwo A. Kusi, Bart W. Faber, Vanessa Riasat, Alan W. Thomas, Clemens H. M. Kocken, and Edmond J. RemarqueFrom:PLoS ONE (Vol. 5, Issue 11) Peer-Reviewed

  Nov. 3, 20108,613 words Article 1680LThere is increasing interest in multi-allele vaccines to overcome strain-specificity against polymorphic vaccine targets such as Apical Membrane Antigen 1 (AMA1). These have been shown to induce broad inhibitory...

• Identification of Plasmodium falciparum circumsporozoite protein-specific CD8+ T cell epitopes in a malaria exposed population

  Authors:Kwadwo A. Kusi, Felix E. Aggor, Linda E. Amoah, Dorothy Anum, Yvonne Nartey, Daniel Amoako-Sakyi, et al.From:PLoS ONE (Vol. 15, Issue 2) Peer-Reviewed

  Feb. 10, 20206,326 words Article 1540LBackground Sterile protection against malaria, most likely mediated by parasite-specific CD8+ T cells, has been achieved by attenuated sporozoite vaccination of animals as well as malaria-naïve and...