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    Academic Journals

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• An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities

  Authors:Jason M Gehrke, Oliver Cervantes, M Kendell Clement, Yuxuan Wu, Jing Zeng, Daniel E Bauer, et al.From:Nature Biotechnology (Vol. 36, Issue 10) Peer-Reviewed

  Nov. 20188,021 words Report 1730LAuthor(s): Jason M Gehrke [1, 2]; Oliver Cervantes [1]; M Kendell Clement [1, 3]; Yuxuan Wu [4]; Jing Zeng [4]; Daniel E Bauer [4]; Luca Pinello [1, 3]; J Keith Joung (corresponding author) [1, 3] Base editor...

• Functionally distinct patterns of nucleosome remodeling at enhancers in glucocorticoid-treated acute lymphoblastic leukemia

  Authors:Jennifer N. Wu, Luca Pinello, Elinor Yissachar, Jonathan W. Wischhusen, Guo-Cheng Yuan, and Charles W. M. RobertsFrom:Epigenetics & Chromatin (Vol. 8, Issue 1) Peer-Reviewed

  Dec. 2, 20159,801 words Article 1530LBackground Precise nucleosome positioning is an increasingly recognized feature of promoters and enhancers, reflecting complex contributions of DNA sequence, nucleosome positioning, histone modification and...

• A one class KNN for signal identification: a biological case study

  Authors:Vito Di Gesu, Giosue Lo Bosco, and Luca PinelloFrom:International Journal of Knowledge Engineering and Soft Data Paradigms (Vol. 1, Issue 4) Peer-Reviewed

  Oct. 19, 2009115 words Case study

   Abstract Only

• Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells

  Authors:Unmesh Jadhav, Kodandaramireddy Nalapareddy, Madhurima Saxena, Nicholas K. O'Neill, Luca Pinello, Guo-Cheng Yuan, et al.From:Cell (Vol. 165, Issue 6) Peer-Reviewed

  June 2, 2016382 words Article

   Abstract Only

• An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level

  Authors:Daniel E. Bauer, Sophia C. Kamran, Samuel Lessard, Jian Xu, Yuko Fujiwara, Carrie Lin, et al.From:Science (Vol. 342, Issue 6155) Peer-Reviewed

  Oct. 11, 2013127 words Author abstract, Rep...

   Abstract Only

• High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

  Authors:Semir Beyaz, Miyeko D. Mana, Jatin Roper, Dmitriy Kedrin, Assieh Saadatpour, Sue-Jean Hong, et al.From:Nature (Vol. 531, Issue 7592) Peer-Reviewed

  Mar. 3, 201612,904 words Report 1580LLittle is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5[sup.+] intestinal stem cells...

• The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing

  Authors:Cary Stelloh, Michael H. Reimer, Kirthi Pulakanti, Steven Blinka, Jonathan Peterson, Luca Pinello, et al.From:Epigenetics & Chromatin (Vol. 9, Issue 14) Peer-Reviewed

  Apr. 15, 201612,416 words Report 1450LBackground The cohesin complex consists of multiple core subunits that play critical roles in mitosis and transcriptional regulation. The cohesin-associated protein Wapal plays a central role in off-loading cohesin...

• Analyzing CRISPR genome-editing experiments with CRISPREsso

  Authors:Luca Pinello, Matthew C. Canver, Megan D. Hoban, Stuart H. Orkin, Donald B. Kohn, Daniel E. Bauer, et al.From:Nature Biotechnology (Vol. 34, Issue 7) Peer-Reviewed

  July 20161,419 words Letter to the editor 1670LTo the Editor: Recent progress in genome editing technologies, in particular the CRISPR-Cas9 nuclease system, has provided new opportunities to investigate the biological functions of genomic sequences by targeted...

• BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

  Authors:Matthew C. Canver, Elenoe C. Smith, Falak Sher, Luca Pinello, Neville E. Sanjana, Ophir Shalem, et al.From:Nature (Vol. 527, Issue 7577) Peer-Reviewed

  Nov. 12, 20159,699 words Report 1390LEnhancers, critical determinants of cellular identity, are commonly recognized by correlative chromatin marks and gain-of-function potential, although only loss-of-function studies can demonstrate their requirement in...