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From:Journal of Clinical Investigation (Vol. 131, Issue 20) Peer-ReviewedThe heterogeneity of human hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) under stress conditions such as ex vivo expansion is poorly understood. Here, we report that the frequencies of...
From:PLoS ONE (Vol. 16, Issue 7) Peer-ReviewedChemokines are small proteins that promote leukocyte migration during development, infection, and inflammation. We and others isolated the unique chemokine CCL21, a potent chemo-attractant for naïve T-cells, naïve...
From:PLoS ONE (Vol. 10, Issue 3) Peer-ReviewedThe production of new blood cells relies on a hierarchical network of hematopoietic stem and progenitor cells (HSPCs). To maintain lifelong hematopoiesis, HSPCs must be protected from ionizing radiation or other...
From:Journal of Clinical Investigation (Vol. 131, Issue 1) Peer-ReviewedBone marrow (BM) hematopoietic stem cells (HSCs) become dysfunctional during aging (i.e., they are increased in number but have an overall reduction in long-term repopulation potential and increased myeloid...
From:Proceedings of the National Academy of Sciences of the United States (Vol. 110, Issue 50) Peer-ReviewedAbstract Only
From:Journal of Clinical Investigation (Vol. 129, Issue 6) Peer-ReviewedThe nuclear protein DEK is an endogenous DNA-binding chromatin factor regulating hematopoiesis. DEK is one of only 2 known secreted nuclear chromatin factors, but whether and how extracellular DEK regulates...
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