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    Academic Journals

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• Generation of cleidocranial dysplasia-specific human induced pluripotent stem cells in completely serum-, feeder-, and integration-free culture

  Authors:Sachiko Yamasaki, Atsuko Hamada, Eri Akagi, Hirotaka Nakatao, Manami Ohtaka, Ken Nishimura, et al.From:In Vitro Cellular & Developmental Biology - Animal (Vol. 52, Issue 2) Peer-Reviewed

  Feb. 2016367 words Report

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• Induction of integration-free human-induced pluripotent stem cells under serum- and feeder-free conditions.

  Authors:Atsuko Hamada, Eri Akagi, Sachiko Yamasaki, Hirotaka Nakatao, Fumitaka Obayashi, Manami Ohtaka, et al.From:In Vitro Cellular & Developmental Biology - Animal (Vol. 56, Issue 1) Peer-Reviewed

  Jan. 2020301 words Report, Brief articl...

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• Robust and highly efficient hiPSC generation from patient non-mobilized peripheral blood-derived CD34+ cells using the auto-erasable Sendai virus vector

  Authors:Takashi Okumura, Yumi Horie, Chen-Yi Lai, Huan-Ting Lin, Hirofumi Shoda, Bunki Natsumoto, et al.From:Stem Cell Research & Therapy (Vol. 10, Issue 1) Peer-Reviewed

  June 24, 20198,996 words Report 1540LBackground Disease modeling with patient-derived induced pluripotent stem cells (iPSCs) is a powerful tool for elucidating the mechanisms underlying disease pathogenesis and developing safe and effective treatments....

• Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model

  Authors:Akiko Saito, Akio Ooki, Takashi Nakamura, Shoko Onodera, Kamichika Hayashi, Daigo Hasegawa, et al.From:Stem Cell Research & Therapy (Vol. 9, Issue 1) Peer-Reviewed

  Jan. 22, 20184,984 words Report 1480LBackground Runt-related transcription factor 2 (RUNX2) haploinsufficiency causes cleidocranial dysplasia (CCD) which is characterized by supernumerary teeth, short stature, clavicular dysplasia, and osteoporosis. At...

• Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells

  Authors:Toshinobu Nishimura, Haojun Xu, Masayuki Iwasaki, Daiki Karigane, Brandon Saavedra, Yusuke Takahashi, et al.From:Gene Therapy (Vol. 27, Issue 10-11) Peer-Reviewed

  Nov. 20195,731 words Report 1470LEmbryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have promising potential for opening new avenues in regenerative medicine. However, since the tumorigenic potential of undifferentiated pluripotent...

• Induction of Noonan syndrome-specific human-induced pluripotent stem cells under serum-, feeder-, and integration-free conditions.

  Authors:Atsuko Hamada, Eri Akagi, Fumitaka Obayashi, Sachiko Yamasaki, Koichi Koizumi, Manami Ohtaka, et al.From:In Vitro Cellular & Developmental Biology - Animal (Vol. 56, Issue 10) Peer-Reviewed

  Dec. 2020279 words Report, Brief articl...

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• Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts

  Authors:Nobutoshi Nawa, Katsuya Hirata, Keiji Kawatani, Toshihiko Nambara, Sayaka Omori, Kimihiko Banno, et al.From:PLoS ONE (Vol. 14, Issue 7) Peer-Reviewed

  July 29, 20199,714 words Report 1460LChromosome abnormalities induces profound alterations in gene expression, leading to various disease phenotypes. Recent studies on yeast and mammalian cells have demonstrated that aneuploidy exerts detrimental effects...

• Novel Strategy to Control Transgene Expression Mediated by a Sendai Virus-Based Vector Using a Nonstructural C Protein and Endogenous MicroRNAs

  Authors:Masayuki Sano, Minoru Iijima, Manami Ohtaka, and Mahito NakanishiFrom:PLoS ONE (Vol. 11, Issue 10) Peer-Reviewed

  Oct. 20, 20168,963 words Article 1490LTissue-specific control of gene expression is an invaluable tool for studying various biological processes and medical applications. Efficient regulatory systems have been utilized to control transgene expression in...

• Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction

  Authors:Daigo Hasegawa, Hiromi Ochiai-Shino, Shoko Onodera, Takashi Nakamura, Akiko Saito, Takeshi Onda, et al.From:PLoS ONE (Vol. 12, Issue 10) Peer-Reviewed

  Oct. 31, 20177,469 words Report 1440LGorlin syndrome is an autosomal dominant inherited syndrome that predisposes a patient to the formation of basal cell carcinomas, odontogenic keratocysts, and skeletal anomalies. Causative mutations in several genes...

• Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes.

  Authors:Kazuo Takayama, Yuta Morisaki, Shuichi Kuno, Yasuhito Nagamoto, Kazuo Harada, Norihisa Furukawa, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 111, Issue 47) Peer-Reviewed

  Nov. 25, 2014169 words Report, Author abstr...

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