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• CRISPResso2 provides accurate and rapid genome editing sequence analysis

  Authors:Kendell Clement, Holly Rees, Matthew C. Canver, Jason M. Gehrke, Rick Farouni, Jonathan Y. Hsu, et al.From:Nature Biotechnology (Vol. 37, Issue 3) Peer-Reviewed

  Mar. 20191,794 words Technical report 1620LAuthor(s): Kendell Clement 1 2 3 , Holly Rees 4 5 6 , Matthew C. Canver 1 2 3 , Jason M. Gehrke 2 3 , Rick Farouni 1 2 3 , Jonathan Y. Hsu 1 2 3 , Mitchel A. Cole 7 , David R. Liu 4 5 6 , J. Keith Joung 2 3 , Daniel E....

• An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level

  Authors:Daniel E. Bauer, Sophia C. Kamran, Samuel Lessard, Jian Xu, Yuko Fujiwara, Carrie Lin, et al.From:Science (Vol. 342, Issue 6155) Peer-Reviewed

  Oct. 11, 2013127 words Author abstract, Rep...

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• Embryonic stem cells as sources of donor-independent platelets

  Authors:Matthew C. Canver, Daniel E. Bauer, and Stuart H. OrkinFrom:Journal of Clinical Investigation (Vol. 125, Issue 7) Peer-Reviewed

  July 20152,435 words Report 1500LThe creation of a donor-independent source of platelets has been challenging; however, recent advances show growing promise for alternative platelet sources. Pluripotent stem cells have the capacity to differentiate...

• Analyzing CRISPR genome-editing experiments with CRISPREsso

  Authors:Luca Pinello, Matthew C. Canver, Megan D. Hoban, Stuart H. Orkin, Donald B. Kohn, Daniel E. Bauer, et al.From:Nature Biotechnology (Vol. 34, Issue 7) Peer-Reviewed

  July 20161,419 words Letter to the editor 1670LTo the Editor: Recent progress in genome editing technologies, in particular the CRISPR-Cas9 nuclease system, has provided new opportunities to investigate the biological functions of genomic sequences by targeted...

• BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

  Authors:Matthew C. Canver, Elenoe C. Smith, Falak Sher, Luca Pinello, Neville E. Sanjana, Ophir Shalem, et al.From:Nature (Vol. 527, Issue 7577) Peer-Reviewed

  Nov. 12, 20159,699 words Report 1390LEnhancers, critical determinants of cellular identity, are commonly recognized by correlative chromatin marks and gain-of-function potential, although only loss-of-function studies can demonstrate their requirement in...

• Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

  Authors:Takeshi Masuda, Xin Wang, Manami Maeda, Matthew C. Canver, Falak Sher, Alister P.W. Funnell, et al.From:Science (Vol. 351, Issue 6270) Peer-Reviewed

  Jan. 15, 2016119 words Author abstract, Rep...

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• Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci.

  Authors:Samuel Lessard, Laurent Francioli, Jessica Alfoldi, Jean-Claude Tardif, Patrick T. Ellinor, Daniel G. MacArthur, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 114, Issue 52) Peer-Reviewed

  Dec. 26, 20179,355 words Report 1450L

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• Lineage-specific BCL11a knockdown circumvents toxicities and reverses sickle phenotype

  Authors:Christian Brendel, Swaroopa Guda, Raffaele Renella, Daniel E. Bauer, Matthew C. Canver, Young-Jo Kim, et al.From:Journal of Clinical Investigation (Vol. 126, Issue 10) Peer-Reviewed

  Oct. 20166,994 words Report 1520LReducing expression of the fetal hemoglobin (HbF) repressor BCL11A leads to a simultaneous increase in [gamma]-globin expression and reduction in [beta]-globin expression. Thus, there is interest in targeting BCL11A as...