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    Academic Journals

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• Discharging of asthma patients

  Authors:Thomas F. Plaut, Michael T. Newhouse, and Thomas F. MorleyFrom:Chest (Vol. 96, Issue 4) Peer-Reviewed

  Oct. 19891,871 words Letter to the editor 2340LTo the Editor: It is common for physicians to delay discharge of the asthmatic patient until he is wheeze-free (Morely et al, "Comparison of beta-adrenergic agents delivered by nebulizer vs metered dose inhaler with...

• Aerosol therapy in infants and toddlers: past, present and future

  Authors:Israel Amirav and Michael T NewhouseFrom:Expert Review of Respiratory Medicine (Vol. 2, Issue 5) Peer-Reviewed

  Oct. 20087,591 words Article 1590LAuthor(s): Israel Amirav [[dagger]] 1 , Michael T Newhouse 2 Keywords: aerosol; asthma; infant; inhaler; nebulizer Infants and toddlers younger than 3 years of age are a unique subpopulation with regard to...

• Is theophylline obsolete?

  Author:Michael T. NewhouseFrom:Chest (Vol. 98, Issue 1) Peer-Reviewed

  July 19901,586 words Editorial Be not the first by whom the new are tried, nor yet the last to lay the old aside. Alexander Pope, 1688-1744. For almost 50 years, methylxanthines have been considered first-line therapy of reversible airflow...

• Laser Resection of a Pedunculated Tracheal Adenoma(*)

  Authors:Michael T. Newhouse, Lee Martin, J. Michael Kay, and John D. MillerFrom:Chest (Vol. 118, Issue 1) Peer-Reviewed

  July 20001,441 words Article We report a case of tracheal adenoma presenting as hemoptysis and reversible airflow obstruction in an ex-smoker. A questionable defect in the tracheal air shadow on a posteroanterior chest radiograph was shown on CT to...

• Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers *. (preliminary reports)

  Authors:Michael T. Newhouse, Peter H. Hirst, Sarma P. Duddu, Yulia H. Walter, Thomas E. Tarara, Andrew R. Clark, et al.From:Chest (Vol. 124, Issue 1) Peer-Reviewed

  July 20034,489 words Article Study objectives: To evaluate the efficiency and reproducibility of pulmonary delivery of an investigational tobramycin PulmoSphere formulation (PStob) [Inhale Therapeutic Systems; San Carlos, CA] by a passive dry...

• The n-of-1 randomized controlled trial: clinical usefulness

  Authors:Gordon H. Guyatt, Jana L. Keller, Roman Jaeschke, David Rosenbloom, Jonathan D. Adachi, and Michael T. NewhouseFrom:Annals of Internal Medicine (Vol. 112, Issue 4) Peer-Reviewed

  Feb. 15, 1990265 words Article

   Abstract Only

• Aerosol Therapy With Valved Holding Chambers in Young Children: Importance of the Facemask Seal

  Authors:Israel Amirav and Michael T. NewhouseFrom:Pediatrics (Vol. 108, Issue 2) Peer-Reviewed

  Aug. 20014,219 words Article Objective. Masks are an essential interface between valved holding chambers (VHCs), or spacers, and a small child's face for providing aerosol therapy. Clinical experience suggests that many young children do not...

• Emergency department management of life-threatening asthma: are nebulizers obsolete?

  Author:Michael T. NewhouseFrom:Chest (Vol. 103, Issue 3) Peer-Reviewed

  Mar. 19931,659 words Editorial Given the worldwide drive to contain rapidly rising health care costs, it seems surprising that wet nebulizers (WNs) continue to be widely regarded as first-line aerosol generation and delivery devices in emergency...

• A Randomized Controlled Trial on the Effect of Inhaled Corticosteroids on Airways Inflammation in Adult Cigarette Smokers

  Authors:Gerard Cox, Lori Whitehead, Myrna Dolovich, Manel Jordana, Jack Gauldie, and Michael T. NewhouseFrom:Chest (Vol. 115, Issue 5) Peer-Reviewed

  May 19995,811 words Article Study objective: To determine whether inhaled corticosteroid treatment can reduce airways inflammation in adult cigarette smokers. Design: This was a randomized, placebo-controlled, double-blinded clinical trial....

• Comment on "Optimizing the Delivery of Inhaled Medication for Respiratory Patients: The Role of Valved Holding Chambers"

  Authors:Michael T. Newhouse and Israel AmiravFrom:Canadian Respiratory JournalPeer-Reviewed

  Aug. 31, 20191,087 words Article 1620LMcIvor et al. [1] recently suggested that regulatory authorities (e.g., US Food and Drug Administration (FDA), Health Canada, and Japan's Pharmaceuticals and Medical Devices Agency) should harmonize and follow the...

• The clinical efficacy of combination nebulized anticholinergic and adrenergic bronchodilators vs nebulized adrenergic bronchodilator alone in acute asthma

  Authors:J. Mark FitzGerald, Anton Grunfeld, Peter D. Pare, Robert D. Levy, Michael T. Newhouse, Richard Hodder, et al.From:Chest (Vol. 111, Issue 2) Peer-Reviewed

  Feb. 19973,374 words Article The role of ipratropium bromide as adjunct therapy to ,B-agonists in acute asthma is uncertain. We therefore decided to compare the use of 3 mg of salbutamol sulfate alone vs 3 mg salbutamol sulfate with 0.5 mg...

• Hemoptysis Due to MDI Therapy in a Patient With Permanent Tracheostomy(*): Treatment With Mask AeroChamber

  Author:Michael T. NewhouseFrom:Chest (Vol. 115, Issue 1) Peer-Reviewed

  Jan. 19991,872 words Article Treatment With Mask AeroChamber Persistent minor hemoptysis resulted from extensive granulation tissue on the main carina and adjacent bronchi due to frequent spraying of metered-dose inhaler (MDI)-generated aerosol...

• Transmission of coronavirus by nebulizer: a serious, underappreciated risk

  Authors:Israel Amirav and Michael T. NewhouseFrom:CMAJ: Canadian Medical Association Journal (Vol. 192, Issue 13) Peer-Reviewed

  Mar. 30, 2020526 words Letter to the editor 1790LThis letter is in response to the news article by Wendy Glauser. (1) The current pandemic of coronavirus disease 2019 (COVID-19) cases demands greater infection control precautions. Nebulizers generate aerosol particles...

• Hospital-based asthma education: achieving the goals and evaluating the outcome

  Author:Michael T. NewhouseFrom:Chest (Vol. 106, Issue 4) Peer-Reviewed

  Oct. 19943,286 words Article Annually, 500 relatively young Canadians die of asthma. Extrapolation from other studies suggests that about 80% of these deaths are avoidable and occur because of poor control of asthma over the long term, failure of...

• Clickhaler (a Novel Dry Powder Inhaler) Provides Similar Bronchodilation to Pressurized Metered-Dose Inhaler, Even at Low Flow Rates

  Authors:Michael T. Newhouse, Normand P. Nantel, Carole B. Chambers, Barbara Pratt, and Mark Parry-BillingsFrom:Chest (Vol. 115, Issue 4) Peer-Reviewed

  Apr. 19992,697 words Product/service eval... Study objective: Comparison of the bronchodilator response to an albuterol novel dry powder inhaler (DPI) (Clickhaler [CH]; ML Laboratories PLC; St. Albans, UK) activated at various inspiratory flow rates and to an...

• Cardiovascular safety of high doses of inhaled fenoterol and albuterol in acute severe asthma

  Authors:Michael T. Newhouse, Kenneth R. Chapman, Andrew L. McCallum, Raja T. Abboud, Dennis M. Bowie, Richard V. Hodder, et al.From:Chest (Vol. 110, Issue 3) Peer-Reviewed

  Sept. 19965,396 words Article Background: It has been suggested that overuse of fenoterol metered-dose inhalers (MDIs) may increase the risk of death from asthma due to cardiac arrhythmias. Our primary objective was to compare the cardiovascular...

• Lung aerosol deposition in suckling infants

  Authors:Israel Amirav, Anthony Luder, Aidah Chleechel, Michael T. Newhouse, and Miguel GorenbergFrom:Archives of Disease in Childhood (Vol. 97, Issue 6) Peer-Reviewed

  June 2012 Clinical report

   Citation Only

• Management of asthma and chronic airflow limitation: are methylxanthines obsolete?

  Authors:Andy Lam and Michael T. NewhouseFrom:Chest (Vol. 98, Issue 1) Peer-Reviewed

  July 19906,726 words Article After almost 50 years as first-line drugs in the management of asthma and COPD, methylxanthines have been largely superceded by inhaled adrenoceptor agonist and anticholinergic bronchodilators which are more potent and...

• Dose-effect relationship of the beta-agonists fenoterol and salbutmol in patients with asthma

  Authors:Michael T. Newhouse, Myrna B. Dolovich, and Farouk KazimFrom:Chest (Vol. 105, Issue 6) Peer-Reviewed

  June 19943,432 words Article Question: What is the relative per microgram potency and side effect profile of the [beta]-agonists salbutamol and fenoterol? Method: The relative bronchodilator ([delta] [FEV.sub.1] V25, V50) potency and side effect...

• Ciliary function, cell viability, and in vitro effect of ribavirin on nasal epithelial cells in acute rhinorrhea

  Authors:Myrna B. Dolovich, James B. Mahony, Carole Chambers, Michael T. Newhouse, and Max A. CherneskyFrom:Chest (Vol. 102, Issue 1) Peer-Reviewed

  July 19921,022 words Article Nasal epithelial (NE) cells were collected from the nasopharynx of 25 individuals with symptomatic colds and 27 healthy volunteers (controls), and ciliary beat frequency (CBF) was assessed by microscopy employing video...