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From:Diabetes Care (Vol. 30, Issue 10) Peer-ReviewedOBJECTIVE--Corneal confocal microscopy (CCM) is a rapid, noninvasive, clinical examination technique that quantifies small nerve fiber pathology. We have used it to assess the neurological benefits of pancreas...
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From:Gene Therapy (Vol. 26, Issue 6) Peer-ReviewedRecombinant Adeno-associated viruses (AAVs) are an attractive vector for gene therapy delivery which may be blocked by AAV neutralising antibodies (NAbs). As Type 1 Diabetes (T1DM) is an endocrine disease of...
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From:Diabetes Care (Vol. 30, Issue 7) Peer-ReviewedThe focus in relation to the consequences of nerve damage in diabetes has been the loss of sensation in the feet predisposing to the development of foot ulceration and lower extremity amputation (1). However, the cornea...
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From:Diabetes Care (Vol. 33, Issue 8) Peer-ReviewedOBJECTIVE--The accurate quantification of human diabetic neuropathy is important to define at-risk patients, anticipate deterioration, and assess new therapies. RESEARCH DESIGN AND METHODS--A total of 101 diabetic...
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From:PLoS ONE (Vol. 10, Issue 4) Peer-ReviewedObjective Corneal innervation is increasingly used as a surrogate marker of human diabetic peripheral neuropathy (DPN) however its temporal relationship with the other microvascular complications of diabetes is not...
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From:PLoS ONE (Vol. 12, Issue 7) Peer-ReviewedObjectives Corneal confocal microscopy (CCM) is a rapid, non-invasive, reproducible technique that quantifies small nerve fibres. We have compared the diagnostic capability of CCM against a range of established...
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From:Diabetes (Vol. 56, Issue 8) Peer-ReviewedSurrogate markers of diabetic neuropathy are being actively sought to facilitate the diagnosis, measure the progression, and assess the benefits of therapeutic intervention in patients with diabetic neuropathy. We have...
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From:Diabetes (Vol. 62, Issue 1) Peer-ReviewedDiabetic neuropathy is associated with increased morbidity and mortality. To date, limited data in subjects with impaired glucose tolerance and diabetes demonstrate nerve fiber repair after intervention. This may...