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    Academic Journals

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• Cannabinoid receptor 1 signaling in hepatocytes and stellate cells does not contribute to NAFLD.

  Authors:Simeng Wang, Qingzhang Zhu, Guosheng Liang, Tania Franks, Magalie Boucher, Kendra K. Bence, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 22) Peer-Reviewed

  Nov. 15, 20218,272 words Report 1390LThe endocannabinoid system regulates appetite and energy expenditure and inhibitors of cannabinoid receptor 1 (CB-1) induce weight loss with improvement in components of the metabolic syndrome. While CB-1 blockage in...

• Phenotypic behavior of caveolin-3 R26Q, a mutant associated with hyperCKemia, distal myopathy, and rippling muscle disease

  Authors:Federica Sotgia, Scott E. Woodman, Gloria Bonuccelli, Franco Capozza, Carlo Minetti, Philipp E. Scherer, et al.From:American Journal of Physiology (Consolidated) (Vol. 285, Issue 5) Peer-Reviewed

  Nov. 2003305 words Author abstract

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• Cab45, a novel Ca2+-binding protein localized to the Golgi lumen

  Authors:Philipp E. Scherer, Gerardo Z. Lederkremer, Suzanne Williams, Michael Fogliano, Guilia Baldini, and Harvey F. LodishFrom:The Journal of Cell Biology (Vol. 133, Issue 1-2) Peer-Reviewed

  Apr. 199693 words Article

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• New zoning laws enforced by glucagon

  Authors:Christine M. Kusminski and Philipp E. SchererFrom:Proceedings of the National Academy of Sciences of the United States (Vol. 115, Issue 17) Peer-Reviewed

  Apr. 24, 20182,046 words Article 1400L

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• A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome

  Authors:Claudia Menzaghi, Tonino Ercolino, Rosa Di Paola, Anders H. Berg, James H. Warram, Philipp E. Scherer, et al.From:Diabetes (Vol. 51, Issue 7) Peer-Reviewed

  July 20025,368 words Article Adiponectin is a protein secreted by adipocytes that modulates insulin action. To assess whether variants of this gene contribute to the prevalence of insulin resistance in Caucasians, we genotyped 413 nondiabetic...

• Acrp30, an Adipocyte-Specific Secretory Protein with Structural Homology to Tumor Necrosis Factor [Alpha]

  Authors:ANDERS H. BERG, KALLOL DAS, MICHAEL RAJALA, LAWRENCE SHAPIRO, and PHILIPP E. SCHERERFrom:Diabetes (Vol. 49, Issue 5) Peer-Reviewed

  May 2000145 words Brief article We have recently identified a serum protein, Acrp30 (adipocyte complement-related protein of 30kDa), a secretory protein expressed exclusively in adipose tissue. Our structural studies established Acrp30 as the founding...

• Selective downregulation of the high-molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects

  Authors:Rita Basu, Utpal B. Pajvani, Robert A. Rizza, and Philipp E. SchererFrom:Diabetes (Vol. 56, Issue 8) Peer-Reviewed

  Aug. 20073,401 words Article 1560LOBJECTIVE--Adiponectin is an adipocyte-specific secretory protein found in circulation in several different forms and is present at significantly lower levels in the plasma of diabetic patients compared with that of...

• Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A.

  Authors:Jessica Cannavino, Mengle Shao, Yu A. An, Svetlana Bezprozvannaya, Shiuhwei Chen, Jiwoong Kim, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 118, Issue 23) Peer-Reviewed

  June 8, 20218,120 words Report 1480L

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• A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive BETA-Cell Hyperplasia.

  Authors:Yu An, Christine M. Kusminski, Alexandra L. Ghaben, Thomas S. Morley, Ricardo J. Samms, Andrew C. Adams, et al.From:Diabetes (Vol. 69, Issue 3) Peer-Reviewed

  Mar. 2020 Report

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• Morphogenesis of the developing mammary gland: Stage-dependent impact of adipocytes

  Authors:Shira Landskroner-Eiger, Jiyoung Park, Davelene Israel, Jeffrey W. Pollard, and Philipp E. SchererFrom:Developmental Biology (Vol. 344, Issue 2) Peer-Reviewed

  Aug. 15, 2010410 words Report

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• ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity

  Authors:Nabila Bouatia-Naji, David Meyre, Stephane Lobbens, Karin Seron, Frederic Fumeron, Beverley Balkau, et al.From:Diabetes (Vol. 55, Issue 2) Peer-Reviewed

  Feb. 20063,790 words Article Common single nucleotide polymorphisms (SNPs) in the ACDC adiponectin encoding gene have been associated with insulin resistance and type 2 diabetes in several populations. Here, we investigate the role of SNPs...

• Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood

  Authors:Christy M. Gliniak and Philipp E. SchererFrom:Journal of Clinical Investigation (Vol. 129, Issue 6) Peer-Reviewed

  June 20192,410 words Article 1370LThe study of beige adipose tissue (BeAT) has recently gained popularity because of its potential as a therapeutic target for the treatment of obesity and other metabolic disorders. While BeAT regulation is well...

• A tribute to Roger H. Unger (1924-2020).

  Authors:Philipp E. Scherer and Christopher B. NewgardFrom:Journal of Clinical Investigation (Vol. 130, Issue 12) Peer-Reviewed

  Dec. 20202,209 words Obituary 1620LA giant in the fields of endocrinology, metabolism, and diabetes research has passed. Roger H. Unger was born on March 7, 1924, in New York City and died in Dallas, Texas, at the age of 96 on August 22, 2020 (Figure 1)....

• Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

  Authors:Maria Apostolopoulou, Ruth Gordillo, Chrysi Koliaki, Sofia Gancheva, Tomas Jelenik, Philipp E. Scherer, et al.From:Diabetes Care (Vol. 41, Issue 6) Peer-Reviewed

  June 2018 Article

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• An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

  Authors:Clair Crewe, Nolwenn Joffin, Joseph M. Rutkowski, Min Kim, Fang Zhang, Dwight A. Towler, et al.From:Cell (Vol. 175, Issue 3) Peer-Reviewed

  Oct. 18, 2018341 words Report

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• Loss of resistin improves glucose homeostasis in leptin deficiency

  Authors:Yong Qi, Zhenying Nie, Yun-Sik Lee, Neel S. Singhal, Philipp E. Scherer, Mitchell A. Lazar, et al.From:Diabetes (Vol. 55, Issue 11) Peer-Reviewed

  Nov. 20064,067 words Article 1530LResistin levels are increased in obesity, and hyperresistinemia impairs glucose homeostasis in rodents. Here, we have determined the role of resistin in ob/ob mice that are obese and insulin resistant because of genetic...

• Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy

  Authors:Jeffrey A. Engelman, XiaoLan Zhang, Ferruccio Galbiati, Daniela Volonte, Federica Sotgia, Richard G. Pestell, et al.From:American Journal of Human Genetics (Vol. 63, Issue 6) Peer-Reviewed

  Dec. 199860 words Article

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• Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injury

  Authors:Ferruccio Galbiati, Daniela Volonte, Orlando Gil, George Zanazzi, James L. Salzer, Massimo Sargiacomo, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 95, Issue 17) Peer-Reviewed

  Aug. 18, 1998196 words Article

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• Hypothalamic resistin induces hepatic insulin resistance

  Authors:Evan D. Muse, Tony K.T. Lam, Philipp E. Scherer, and Luciano RossettiFrom:Journal of Clinical Investigation (Vol. 117, Issue 6) Peer-Reviewed

  June 20076,501 words Clinical report 1500LCirculating resistin stimulates endogenous glucose production (GP). Here, we report that bi-directional changes in hypothalamic resistin action have dramatic effects on GP and proinflammatory cytokine expression in the...

• Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

  Authors:Yu A An, Kai Sun, Nolwenn Joffin, Fang Zhang, Yingfeng Deng, Olivier Donze, et al.From:eLife (Vol. 6) Peer-Reviewed

  Mar. 29, 201713,210 words Report 1440LDespite many angiogenic factors playing crucial roles in metabolic homeostasis, effects of angiopoietin-2 (ANG-2) in adipose tissue (AT) remain unclear. Utilizing a doxycycline-inducible AT-specific ANG-2 overexpression...