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    Academic Journals

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• Hypothyroxinemia: Zoeller's response

  Author:R. Thomas ZoellerFrom:Environmental Health Perspectives (Vol. 112, Issue 5) Peer-Reviewed

  Apr. 2004635 words Article Soldin addresses an important issue that was not fully developed in my editorial (Zoeller 2003a), specifically, the description of thyroid status in experimental animals designed to model human conditions. There are two...

• A clash of old and new scientific concepts in toxicity, with important implications for public health

  Authors:John Peterson Myers, R. Thomas Zoeller, and Frederick S. vom SaalFrom:Environmental Health Perspectives (Vol. 117, Issue 11) Peer-Reviewed

  Nov. 20093,671 words Report 1590LBACKGROUND: A core assumption of current toxicologic procedures used to establish health standards for chemical exposures is that testing the safety of chemicals at high doses can be used to predict the effects of...

• Maternal polybrominated diphenyl ether (PBDE) exposure and thyroid hormones in maternal and cord sera: the HOME Study, Cincinnati, USA

  Authors:Ann M. Vuong, Glenys M. Webster, Megan E. Romano, Joseph M. Braun, R. Thomas Zoeller, Andrew N. Hoofnagle, et al.From:Environmental Health Perspectives (Vol. 123, Issue 10) Peer-Reviewed

  Oct. 20155,987 words Report 1390LBACKGROUND: Polybrominated diphenyl ethers (PBDEs) reduce blood concentrations of thyroid hormones in laboratory animals, but it is unclear whether PBDEs disrupt thyroid hormones in pregnant women or newborn infants....

• Thyroid toxicology and brain development: should we think differently?

  Author:R. Thomas ZoellerFrom:Environmental Health Perspectives (Vol. 111, Issue 12) Peer-Reviewed

  Sept. 20031,103 words Article Thyroid hormone (TH) is essential for normal brain development. The simplicity of this statement, however, dramatically understates the complexity of the issues confronting us as we develop ways to identify factors in...

• Meeting report: moving upstream--evaluating adverse upstream end points for improved risk assessment and Decision-Making

  Authors:Tracey J. Woodruff, Lauren Zeise, Daniel A. Axelrad, Kathryn Z. Guyton, Sarah Janssen, Mark Miller, et al.From:Environmental Health Perspectives (Vol. 116, Issue 11) Peer-Reviewed

  Nov. 20089,058 words Article 1500LBACKGROUND: Assessing adverse effects from environmental chemical exposure is integral to public health policies- Toxicology assays identifying early biological changes from chemical exposure are increasing our ability...

• Thyroid Hormone May Regulate mRNA Abundance in Liver by Acting on MicroRNAs

  Authors:Hongyan Dong, Martin Paquette, Andrew Williams, R. Thomas Zoeller, Mike Wade, and Carole YaukFrom:PLoS ONE (Vol. 5, Issue 8) Peer-Reviewed

  Aug. 13, 20105,806 words Article 1440LMicroRNAs (miRNAs) are extensively involved in diverse biological processes. However, very little is known about the role of miRNAs in mediating the action of thyroid hormones (TH). Appropriate TH levels are known to be...

• Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes

  Authors:Kevin M. Crofton, Mark D. Miller, Deborah C. Rice, and R. Thomas ZoellerFrom:Environmental Health Perspectives (Vol. 117, Issue 7) Peer-Reviewed

  July 20099,205 words Report 1470LBACKGROUND: There is increasing evidence in humans and in experimental animals for a relationship between exposure to specific environmental chemicals and perturbations in levels of critically important thyroid hormones...

• Evaluation of the U.S. EPA/OSWER preliminary remediation goal for perchlorate in groundwater: focus on exposure to nursing infants

  Authors:Gary L. Ginsberg, Dale B. Hattis, R. Thomas Zoeller, and Deborah C. RiceFrom:Environmental Health Perspectives (Vol. 115, Issue 3) Peer-Reviewed

  Mar. 200710,112 words Clinical report 1410LBACKGROUND: Perchlorate is a common contaminant of drinking water and food. It competes with iodide for uptake into the thyroid, thus interfering with thyroid hormone production. The U.S. Environmental Protection...

• Molecular mechanisms of signal integration in hypothalamic neurons

  Authors:R. Thomas Zoeller, Nisreen Kabeer, and H. Elliott AlbersFrom:American Zoologist (Vol. 33, Issue 2) Peer-Reviewed

  Apr. 1993221 words Article

   Abstract Only

• Alteration of Rat Fetal Cerebral Cortex Development after Prenatal Exposure to Polychlorinated Biphenyls

  Authors:Elise Naveau, Anneline Pinson, Arlette Gerard, Laurent Nguyen, Corinne Charlier, Jean-Pierre Thome, et al.From:PLoS ONE (Vol. 9, Issue 3) Peer-Reviewed

  Mar. 18, 20147,508 words Article 1440LAuthor(s): Elise Naveau 1, Anneline Pinson 1, Arlette Gérard 1, Laurent Nguyen 2, Corinne Charlier 3, Jean-Pierre Thomé 4, R. Thomas Zoeller 5, Jean-Pierre Bourguignon 1, Anne-Simone Parent 1,* Introduction...

• Identification of Thyroid Hormone Receptor Binding Sites and Target Genes Using ChIP-on-Chip in Developing Mouse Cerebellum

  Authors:Hongyan Dong, Carole L. Yauk, Andrea Rowan-Carroll, Seo-Hee You, R. Thomas Zoeller, Iain Lambert, et al.From:PLoS ONE (Vol. 4, Issue 2) Peer-Reviewed

  Feb. 25, 20096,901 words Article 1470LThyroid hormone (TH) is critical to normal brain development, but the mechanisms operating in this process are poorly understood. We used chromatin immunoprecipitation to enrich regions of DNA bound to thyroid receptor...

• Why Public Health agencies cannot depend on Good Laboratory Practices as a criterion for selecting data: the case of bisphenol A

  Authors:John Peterson Myers, Frederick S. vom Saal, Benson T. Akingbemi, Koji Arizono, Scott Belcher, Theo Colborn, et al.From:Environmental Health Perspectives (Vol. 117, Issue 3) Peer-Reviewed

  Mar. 20099,079 words Article 1540LBACKGROUND: In their safety evaluations of bisphenol A (BPA), the U.S. Food and Drug Administration (FDA) and a counterpart in Europe, the European Food Safety Authority (EFSA), have given special prominence to two...

• The florence statement on triclosan and triclocarban

  Authors:Rolf U. Halden, Avery E. Lindeman, Allison E. Aiello, David Andrews, William A. Arnold, Patricia Fair, et al.From:Environmental Health Perspectives (Vol. 125, Issue 6) Peer-Reviewed

  June 201713,690 words Article 1490LThe Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and...

• A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse

  Authors:Anthony J. Mason, Joel S. Hayflick, R. Thomas Zoeller, W. Scott Young, III, Heidi S. Phillips, Karoly Nikolics, et al.From:Science (Vol. 234) Peer-Reviewed

  Dec. 12, 19864,998 words Article A Deletion Truncating the Gonadotropin-Releasing Hormone Gene Is, Responsible for Hypogonadism in the hpg Mouse THE CENTRAL REGULATION OF REPRODUCTIVE COMPETENCE in mammals is mediated by the activity of hypothalamic...

• Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors

  Authors:Kelly J. Gauger, Yoshihisa Kato, Koichi Haraguchi, Hans-Joachim Lehmler, Larry W. Robertson, Ruby Bansal, et al.From:Environmental Health Perspectives (Vol. 112, Issue 5) Peer-Reviewed

  Apr. 20046,906 words Article Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants routinely found in human and animal tissues. Developmental exposure to PCBs is associated with neuropsychologic deficits, which may be related...

• Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells

  Authors:Kelly J. Gauger, Stefanie Giera, David S. Sharlin, Ruby Bansal, Eric Iannacone, and R. Thomas ZoellerFrom:Environmental Health Perspectives (Vol. 115, Issue 11) Peer-Reviewed

  Nov. 20077,269 words Report 1400LBACKGROUND: Polychlorinated biphenyls (PCBs) may interfere with thyroid hormone (TH) signaling by reducing TH levels in blood, by exerting direct effects on TH receptors (TRs), or both. OBJECTIVE: Our objective was to...

• The impact of endocrine disruption: a consensus statement on the state of the science

  Authors:Ake Bergman, Jerrold J. Heindel, Tim Kasten, Karen A. Kidd, Susan Jobling, Maria Neira, et al.From:Environmental Health Perspectives (Vol. 121, Issue 4) Peer-Reviewed

  Apr. 20133,644 words Editorial 1450LIn 2002, the joint International Programme on Chemical Safety (IPCS) of the World Health Organization (WHO), the United Nations Environment Programme (UNEP), and the International Labour Organisation (ILO) published a...