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    Academic Journals

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• Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts.

  Authors:Sarah M.C. Colbert, Frank R. Wendt, Gita A. Pathak, Drew A. Helmer, Elizabeth R. Hauser, Matthew C. Keller, et al.From:American Journal of Human Genetics (Vol. 110, Issue 6) Peer-Reviewed

  June 1, 2023509 words Report

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• A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension.

  Authors:Kushan L. Gunawardhana, Lingjuan Hong, Trojan Rugira, Severin Uebbing, Joanna Kucharczak, Sameet Mehta, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20238,963 words Report 1380LGenetic variants in the third intron of the PRDM6 gene have been associated with BP traits in multiple GWAS. By combining fine mapping, massively parallel reporter assays, and gene editing, we identified super enhancers...

• Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits

  Authors:Renato Polimanti, Bao Zhu Yang, Hongyu Zhao, and Joel GelernterFrom:PLoS ONE (Vol. 11, Issue 8) Peer-Reviewed

  Aug. 18, 20166,001 words Report 1560LMany signals of natural selection have been identified in the human genome. However, except for some single-locus mechanisms, most molecular processes generating these adaptation signals are still unknown. We developed...

• GSTM1, GSTP1, and GSTT1 genetic variability in Turkish and worldwide populations

  Authors:Sefayet Karaca, Mehmet Karaca, Tomris Cesuroglu, Sema Erge, and Renato PolimantiFrom:American Journal of Human Biology (Vol. 27, Issue 3) Peer-Reviewed

  May-June 2015244 words Report

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• Human genetic variation of CYP450 superfamily: analysis of functional diversity in worldwide populations

  Authors:Renato Polimanti, Sara Piacentini, Dario Manfellotto, and Maria FuciarelliFrom:Pharmacogenomics (Vol. 13, Issue 16) Peer-Reviewed

  Dec. 20125,493 words Report 1450LAuthor(s): Renato Polimanti [*] 3 , Sara Piacentini 1 , Dario Manfellotto 2 , Maria Fuciarelli 1 KEYWORDS : ethnicity; genetic predisposition to disease; genetic predisposition to drug response; genome scan;...

• Genome-wide association studies of posttraumatic stress disorder in 2 cohorts of US army soldiers

  Authors:Murray B. Stein, Chia-Yen Chen, Robert J. Ursano, Tianxi Cai, Joel Gelernter, Steven G. Heeringa, et al.From:JAMA Psychiatry (Vol. 73, Issue 7) Peer-Reviewed

  July 2016 Report

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• S100A10 identified in a genome-wide gene x cannabis dependence interaction analysis of risky sexual behaviours

  Authors:Renato Polimanti, Shashwath A. Meda, Godfrey D. Pearlson, Hongyu Zhao, Richard Sherva, Lindsay A. Farrer, et al.From:Journal of Psychiatry and Neuroscience (Vol. 42, Issue 4) Peer-Reviewed

  July 20176,414 words Report 1710LBackground: We conducted a genome-wide gene x environment interaction analysis to identify genetic variants that interact with cannabis dependence (CaD) in influencing risky sexual behaviours (RSB). Methods: Our sample...

• Human pharmacogenomic variation of antihypertensive drugs: from population genetics to personalized medicine

  Authors:Renato Polimanti, Andrea Iorio, Sara Piacentini, Dario Manfellotto, and Maria FuciarelliFrom:Pharmacogenomics (Vol. 15, Issue 2) Peer-Reviewed

  Feb. 20145,655 words Report 1420LAuthor(s): Renato Polimanti [*] 3 , Andrea Iorio 2 , Sara Piacentini 1 , Dario Manfellotto 2 , Maria Fuciarelli 1 KEYWORDS : bioinformatics; blood pressure; drugs; geographic origin; hypertension;...

• Association between the c. 2495 A>G ATP7B Polymorphism and Sporadic Alzheimer's disease

  Authors:Serena Bucossi, Stefania Mariani, Mariacarla Ventriglia, Renato Polimanti, Massimo Gennarelli, Cristian Bonvicini, et al.From:International Journal of Alzheimer's DiseasePeer-Reviewed

  Annual 20115,981 words Report 1480LNonceruloplasmin-bound copper ("free") is reported to be elevated in Alzheimer's disease (AD). In Wilson's disease (WD) Cu-ATPase 7B protein tightly controls free copper body levels. To explore whether the ATP7B gene...

• Copper status in Alzheimer's disease and other neurodegenerative disorders 2013

  Authors:Rosanna Squitti, Tjaard Hoogenraad, George Brewer, Ashley I. Bush, and Renato PolimantiFrom:International Journal of Alzheimer's DiseasePeer-Reviewed

  Annual 2013723 words Editorial 1470LIn recent years, the number of studies about the role of copper metabolism in the pathophysiology of Alzheimer's disease (AD) has been rapidly increasing. A wide range of experimental approaches have been used to...

• Dissecting ancestry genomic background in substance dependence genome-wide association studies

  Authors:Renato Polimanti, Can Yang, Hongyu Zhao, and Joel GelernterFrom:Pharmacogenomics (Vol. 16, Issue 13) Peer-Reviewed

  Aug. 20157,690 words Report 1710LAuthor(s): Renato Polimanti aff1 aff2 , Can Yang aff1 aff3 , Hongyu Zhao aff3 aff4 , Joel Gelernter [*] aff1 aff2 aff4 aff5 Keywords: African-Americans; ethnicity; European-Americans; substance dependence...

• International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events

  Authors:Sefayet Karaca, Nujen Colak Bozkurt, Tomris Cesuroglu, Mehmet Karaca, Mehmet Bozkurt, Erdal Eskioglu, et al.From:Pharmacogenomics (Vol. 16, Issue 10) Peer-Reviewed

  July 20156,291 words Report 1790LAuthor(s): Sefayet Karaca [*] aff1 aff2 , Nujen Colak Bozkurt aff3 , Tomris Cesuroglu aff2 aff4 , Mehmet Karaca aff5 , Mehmet Bozkurt aff6 , Erdal Eskioglu aff7 , Renato Polimanti aff8 Keywords: drug response;...

• Functional diversity of the glutathione peroxidase gene family among human populations: implications for genetic predisposition to disease and drug response

  Authors:Renato Polimanti, Maria Fuciarelli, Giovanni Destro-Bisol, and Cinzia BattaggiaFrom:Pharmacogenomics (Vol. 14, Issue 9) Peer-Reviewed

  July 20135,776 words Report 1470LAuthor(s): Renato Polimanti [*] 3 , Maria Fuciarelli 1 , Giovanni Destro-Bisol 2 , Cinzia Battaggia 2 KEYWORDS : ethnicity; functional prediction analysis; GPX genes; haplotype analysis; selenoproteins...

• Functional variability of glutathione S-transferases in basque populations

  Authors:Andrea Iorio, Sara Piacentini, Renato Polimanti, Flavio De Angelis, Rosario Calderon, and Maria FuciarelliFrom:American Journal of Human Biology (Vol. 26, Issue 3) Peer-Reviewed

  May-June 2014244 words Author abstract, Rep...

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• Copper status in Alzheimer's disease and other neurodegenerative disorders 2013

  Authors:Rosanna Squitti, Tjaard Hoogenraad, George Brewer, Ashley I. Bush, and Renato PolimantiFrom:International Journal of Alzheimer's DiseasePeer-Reviewed

  Annual 2014719 words Editorial 1460LIn recent years, the number of studies about the role of copper metabolism in the pathophysiology of Alzheimer's disease (AD) has been rapidly increasing. A wide range of experimental approaches have been used to...

• Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression

  Authors:Hang Zhou, Renato Polimanti, and Bao-Zhu YangFrom:JAMA Psychiatry (Vol. 74, Issue 12) Peer-Reviewed

  Dec. 2017 Article

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