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    Academic Journals

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• Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors

  Authors:Johannes L. Zakrzewski, David Suh, John C. Markley, Odette M. Smith, Christopher King, Gabrielle L. Goldberg, et al.From:Nature Biotechnology (Vol. 26, Issue 4) Peer-Reviewed

  Apr. 20086,233 words Report 1640LWe present a strategy for adoptive immunotherapy using T-lineage committed lymphoid precursor cells generated by Notchl-based culture. We found that allogeneic T-cell precursors can be transferred to irradiated...

• Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

  Authors:Renier J. Brentjens, Jean-Baptiste Latouche, Elmer Santos, Francesc Marti, Michael C. Gong, Clay Lyddane, et al.From:Nature Medicine (Vol. 9, Issue 3) Peer-Reviewed

  Mar. 20037,449 words Article 1710LThe genetic transfer of antigen receptors provides a means to rapidly generate autologous tumor-reactive T lymphocytes. However, recognition of tumor antigens by cytotoxic T cells is only one step towards effective...

• T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection

  Authors:Matthias T Stephan, Vladimir Ponomarev, Renier J Brentjens, Alex H Chang, Konstantin V Dobrenkov, Glenn Heller, et al.From:Nature Medicine (Vol. 13, Issue 12) Peer-Reviewed

  Dec. 20078,906 words Article To reject tumors, T cells must overcome poor tumor immunogenicity and an adverse tumor microenvironment. Providing agonistic costimulatory signals to tumor-infiltrating T cells to augment T cell function remains a...

• In Vivo Imaging Enables High Resolution Preclinical Trials on Patients' Leukemia Cells Growing in Mice

  Authors:Nadia Terziyska, Catarina Castro Alves, Volker Groiss, Katja Schneider, Katarina Farkasova, Manfred Ogris, et al.From:PLoS ONE (Vol. 7, Issue 12) Peer-Reviewed

  Dec. 31, 20127,306 words Article 1410LBackground Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines....

• Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

  Authors:Sarwish Rafiq, Oladapo O Yeku, Hollie J Jackson, Terence J Purdon, Dayenne G van Leeuwen, Dylan J Drakes, et al.From:Nature Biotechnology (Vol. 36, Issue 9) Peer-Reviewed

  Oct. 20189,948 words Report 1530LThe efficacy of chimeric antigen receptor (CAR) T cell therapy against poorly responding tumors can be enhanced by administering the cells in combination with immune checkpoint blockade inhibitors. Alternatively, the...

• Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells

  Authors:Michael Boice, Darin Salloum, Frederic Mourcin, Viraj Sanghvi, Rada Amin, Elisa Oricchio, et al.From:Cell (Vol. 167, Issue 2) Peer-Reviewed

  Oct. 6, 2016537 words Article

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• Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

  Authors:H. Park Jae, Isabelle Riviere, Mithat Gonen, Wang Xiuyan, Brigitte Senechal, Kevin J. Curran, et al.From:The New England Journal of Medicine (Vol. 378, Issue 5) Peer-Reviewed

  Feb. 1, 201849 words Report

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• CAR therapy for hematological cancers: can success seen in the treatment of B-cell acute lymphoblastic leukemia be applied to other hematological malignancies?

  Authors:Hollie J Pegram, Eric L Smith, Sarwish Rafiq, and Renier J BrentjensFrom:Immunotherapy (Vol. 7, Issue 5) Peer-Reviewed

  May 201513,468 words Report 1630LAuthor(s): Hollie J Pegram aff1 , Eric L Smith aff1 , Sarwish Rafiq aff1 , Renier J Brentjens [*] aff1 aff2 aff3 Keywords: autologous T-cell infusion; B-cell malignancies; CAR; chimeric antigen receptor;...

• Novel approaches to immunotherapy for B-cell malignancies

  Author:Renier J. BrentjensFrom:Current Oncology Reports (Vol. 6, Issue 5)

  Oct. 2004169 words Article

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• Novel approaches to the immunotherapy of B-cell malignancies: An update

  Author:Renier J. BrentjensFrom:Current Hematologic Malignancy Reports (Vol. 1, Issue 4)

  Dec. 2006181 words Article

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• Fine tangled pili expressed by Haemophilis ducreyi are a novel class of pili

  Authors:Renier J. Brentjens, Margaret Ketterer, Michael A. Apicella, and Stanley M. SpinolaFrom:Journal of Bacteriology (Vol. 178, Issue 3-4) Peer-Reviewed

  Feb. 199670 words Article

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• Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase

  Authors:Elmer B. Santos, Raymond Yeh, James Lee, Yan Nikhamin, Blesida Punzalan, Blesserene Punzalan, et al.From:Nature Medicine (Vol. 15, Issue 3) Peer-Reviewed

  Mar. 20094,720 words Report 1650LWe developed a new approach to bioluminescent T cell imaging using a membrane-anchored form of the Gaussia luciferase (GLuc) enzyme, termed extGLuc, which we could stably express in both mouse and human primary T cells....

• Tumors evading CARs--the chase is on

  Authors:Sarwish Rafiq and Renier J. BrentjensFrom:Nature Medicine (Vol. 24, Issue 10) Peer-Reviewed

  Oct. 20181,572 words Article 1600LAcquired resistance to CD19-targeted CAR T cell therapy can occur through mutations in the CD19 gene or after insertion of a chimeric antigen receptor (CAR) into leukemia cells, resulting in the adjacent receptor being...

• Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCR[zeta] /CD28 receptor

  Authors:John Maher, Renier J. Brentjens, Gertrude Gunset, Isabelle Riviere, and Michel SadelainFrom:Nature Biotechnology (Vol. 20, Issue 1) Peer-Reviewed

  Jan. 20025,851 words Article 1510LArtificial receptors provide a promising approach to target T lymphocytes to tumor antigens. However, the receptors described thus far produce either an activation or a co-stimulatory signal alone, thus limiting the...