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From:Mayo Clinic Proceedings (Vol. 83, Issue 2) Peer-ReviewedOBJECTIVE: To test the hypothesis that allelic variants of the paraoxonase-1 gene are associated with endothelial dysfunction, an early stage of atherosclerosis. PATIENTS AND METHODS: We assessed 192Q>R and 55L>M...
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From:Molecular Diagnosis & Therapy (Vol. 11, Issue 4) Peer-ReviewedThe role of inflammation in atherosclerosis continues to emerge. Lipoprotein-associated phospholipase [A.sub.2] ([Lp-PLA.sub.2]), a novel plasma biomarker, circulates in the blood bound mainly to low-density lipoprotein...